Genomic Analysis of Novel Bacterial Species <i>Corynebacterium ramonii</i> ST344 Clone Strains Isolated from Human Skin Ulcer and Rescued Cats in Japan
Some <i>Corynebacterium</i> strains produce toxins that are similar to those produced by <i>Corynebacterium diphtheriae</i>, leading to human infections that are often transmitted through zoonotic diseases. A novel species, which is formerly classified as <i>Corynebacte...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Zoonotic Diseases |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2813-0227/4/4/20 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850058421323169792 |
|---|---|
| author | Chie Shitada Mikoto Moriguchi Hideyuki Hayashi Kazutoshi Matsumoto Misato Mori Eisuke Tokuoka Shunsuke Yahiro Shouichirou Gejima Kazuhiro Horiba Takatoshi Yamamoto Motohide Takahashi Makoto Kuroda |
| author_facet | Chie Shitada Mikoto Moriguchi Hideyuki Hayashi Kazutoshi Matsumoto Misato Mori Eisuke Tokuoka Shunsuke Yahiro Shouichirou Gejima Kazuhiro Horiba Takatoshi Yamamoto Motohide Takahashi Makoto Kuroda |
| author_sort | Chie Shitada |
| collection | DOAJ |
| description | Some <i>Corynebacterium</i> strains produce toxins that are similar to those produced by <i>Corynebacterium diphtheriae</i>, leading to human infections that are often transmitted through zoonotic diseases. A novel species, which is formerly classified as <i>Corynebacterium ulcerans</i> lineage II, was recently re-evaluated and renamed “<i>Corynebacterium ramonii</i> sp. nov.”. We isolated <i>C. ramonii</i> from a human skin ulcer in Japan in 2023 (KCU0303-001) and identified it as ST344 using a genomic analysis. In addition, <i>C. ramonii</i> KPHES-18084 (ST344) and six strains of <i>C. ulcerans</i> (ST337/ST1011) were isolated from the oral cavities of 7/208 rescued cats (3.4%). The human ulcer strain KCU0303-001 and the rescued cat strain KPHES-18084 were found to be ST344 and closely related clones by core-genome and pan-genome analyses, suggesting that ST344 may be endemic to both clinical and companion animals in Japan. In support of this finding, another clinical isolate of ST344 (TSU-28 strain) was reported in Japan in 2019. Although ST337 is the most common <i>C. ulcerans</i> infection, the second most recent clinical isolate of <i>C. ramonii</i>, ST344, might be increasing; therefore, further genomic surveillance is required to monitor <i>C. ramonii</i> and <i>C. ulcerans</i> infections. |
| format | Article |
| id | doaj-art-87e40adc73214a819c60284a101cf50e |
| institution | DOAJ |
| issn | 2813-0227 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Zoonotic Diseases |
| spelling | doaj-art-87e40adc73214a819c60284a101cf50e2025-08-20T02:51:10ZengMDPI AGZoonotic Diseases2813-02272024-10-014423424410.3390/zoonoticdis4040020Genomic Analysis of Novel Bacterial Species <i>Corynebacterium ramonii</i> ST344 Clone Strains Isolated from Human Skin Ulcer and Rescued Cats in JapanChie Shitada0Mikoto Moriguchi1Hideyuki Hayashi2Kazutoshi Matsumoto3Misato Mori4Eisuke Tokuoka5Shunsuke Yahiro6Shouichirou Gejima7Kazuhiro Horiba8Takatoshi Yamamoto9Motohide Takahashi10Makoto Kuroda11Toxin and Biologicals Research Laboratory, Kumamoto Health Science University, 325 Izumi-machi, Kita-ku, Kumamoto 861-5598, JapanKumamoto Rosai Hospital Clinical Laboratory Center, Yatsushiro 866-0826, JapanKumamoto University Hospital Clinical Laboratory Center, Kumamoto 860-8556, JapanKumamoto Prefectural Institute of Public Health and Environmental Science, Uto 869-0425, JapanKumamoto Prefectural Institute of Public Health and Environmental Science, Uto 869-0425, JapanKumamoto Prefectural Institute of Public Health and Environmental Science, Uto 869-0425, JapanKumamoto Prefectural Institute of Public Health and Environmental Science, Uto 869-0425, JapanKumamoto Prefectural Institute of Public Health and Environmental Science, Uto 869-0425, JapanPathogen Genomics Center, National Institute of Infectious Diseases, Tokyo 162-8640, JapanDepartment of Medical Technology, Faculty of Health Sciences, Kumamoto Health Science University, 325 Izumi-machi, Kita-ku, Kumamoto 861-5598, JapanToxin and Biologicals Research Laboratory, Kumamoto Health Science University, 325 Izumi-machi, Kita-ku, Kumamoto 861-5598, JapanDepartment of Medical Technology, Faculty of Health Sciences, Kumamoto Health Science University, 325 Izumi-machi, Kita-ku, Kumamoto 861-5598, JapanSome <i>Corynebacterium</i> strains produce toxins that are similar to those produced by <i>Corynebacterium diphtheriae</i>, leading to human infections that are often transmitted through zoonotic diseases. A novel species, which is formerly classified as <i>Corynebacterium ulcerans</i> lineage II, was recently re-evaluated and renamed “<i>Corynebacterium ramonii</i> sp. nov.”. We isolated <i>C. ramonii</i> from a human skin ulcer in Japan in 2023 (KCU0303-001) and identified it as ST344 using a genomic analysis. In addition, <i>C. ramonii</i> KPHES-18084 (ST344) and six strains of <i>C. ulcerans</i> (ST337/ST1011) were isolated from the oral cavities of 7/208 rescued cats (3.4%). The human ulcer strain KCU0303-001 and the rescued cat strain KPHES-18084 were found to be ST344 and closely related clones by core-genome and pan-genome analyses, suggesting that ST344 may be endemic to both clinical and companion animals in Japan. In support of this finding, another clinical isolate of ST344 (TSU-28 strain) was reported in Japan in 2019. Although ST337 is the most common <i>C. ulcerans</i> infection, the second most recent clinical isolate of <i>C. ramonii</i>, ST344, might be increasing; therefore, further genomic surveillance is required to monitor <i>C. ramonii</i> and <i>C. ulcerans</i> infections.https://www.mdpi.com/2813-0227/4/4/20<i>Corynebacterium ramonii</i>ST344<i>Corynebacterium ulcerans</i>ulcerzoonotic diseasesdiphtheria toxin |
| spellingShingle | Chie Shitada Mikoto Moriguchi Hideyuki Hayashi Kazutoshi Matsumoto Misato Mori Eisuke Tokuoka Shunsuke Yahiro Shouichirou Gejima Kazuhiro Horiba Takatoshi Yamamoto Motohide Takahashi Makoto Kuroda Genomic Analysis of Novel Bacterial Species <i>Corynebacterium ramonii</i> ST344 Clone Strains Isolated from Human Skin Ulcer and Rescued Cats in Japan Zoonotic Diseases <i>Corynebacterium ramonii</i> ST344 <i>Corynebacterium ulcerans</i> ulcer zoonotic diseases diphtheria toxin |
| title | Genomic Analysis of Novel Bacterial Species <i>Corynebacterium ramonii</i> ST344 Clone Strains Isolated from Human Skin Ulcer and Rescued Cats in Japan |
| title_full | Genomic Analysis of Novel Bacterial Species <i>Corynebacterium ramonii</i> ST344 Clone Strains Isolated from Human Skin Ulcer and Rescued Cats in Japan |
| title_fullStr | Genomic Analysis of Novel Bacterial Species <i>Corynebacterium ramonii</i> ST344 Clone Strains Isolated from Human Skin Ulcer and Rescued Cats in Japan |
| title_full_unstemmed | Genomic Analysis of Novel Bacterial Species <i>Corynebacterium ramonii</i> ST344 Clone Strains Isolated from Human Skin Ulcer and Rescued Cats in Japan |
| title_short | Genomic Analysis of Novel Bacterial Species <i>Corynebacterium ramonii</i> ST344 Clone Strains Isolated from Human Skin Ulcer and Rescued Cats in Japan |
| title_sort | genomic analysis of novel bacterial species i corynebacterium ramonii i st344 clone strains isolated from human skin ulcer and rescued cats in japan |
| topic | <i>Corynebacterium ramonii</i> ST344 <i>Corynebacterium ulcerans</i> ulcer zoonotic diseases diphtheria toxin |
| url | https://www.mdpi.com/2813-0227/4/4/20 |
| work_keys_str_mv | AT chieshitada genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT mikotomoriguchi genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT hideyukihayashi genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT kazutoshimatsumoto genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT misatomori genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT eisuketokuoka genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT shunsukeyahiro genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT shouichirougejima genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT kazuhirohoriba genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT takatoshiyamamoto genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT motohidetakahashi genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan AT makotokuroda genomicanalysisofnovelbacterialspeciesicorynebacteriumramoniiist344clonestrainsisolatedfromhumanskinulcerandrescuedcatsinjapan |