Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps
IntroductionThis study investigated low-density scalp electrical source imaging of the ictal onset zone and interictal spike ripple high-frequency oscillation networks using source coherence maps in the pediatric epilepsy surgical workup. Intracranial monitoring, the gold standard for determining ep...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1483977/full |
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| author | Parnia Sadeghzadeh Alexander Freibauer Rajesh RamachandranNair Robyn Whitney Mutaz Al Nassar Puneet Jain Elizabeth Donner Ayako Ochi Kevin C. Jones |
| author_facet | Parnia Sadeghzadeh Alexander Freibauer Rajesh RamachandranNair Robyn Whitney Mutaz Al Nassar Puneet Jain Elizabeth Donner Ayako Ochi Kevin C. Jones |
| author_sort | Parnia Sadeghzadeh |
| collection | DOAJ |
| description | IntroductionThis study investigated low-density scalp electrical source imaging of the ictal onset zone and interictal spike ripple high-frequency oscillation networks using source coherence maps in the pediatric epilepsy surgical workup. Intracranial monitoring, the gold standard for determining epileptogenic zones, has limited spatial sampling. Source coherence analysis presents a promising new non-invasive technique.MethodsThis was a retrospective review of 12 patients who underwent focal resections. Source coherence maps were generated using standardized low-resolution electromagnetic tomography and concordance to resection margins was assessed, noting outcomes at 3 years post-surgery.ResultsIctal source coherence maps were performed in 7/12 patients. Six of seven included the surgical resection. Five of seven cases were seizure free post-resection. Interictal spike ripple electrical source imaging and interictal spike ripple high-frequency oscillation networks using source coherence maps were performed for three cases, with two of three included in the resection and all three were seizure free.DiscussionThese findings may provide proof of principle supporting low-density scalp electrical source imaging of the ictal onset zone and spike ripple network using source coherence maps. This promising method is complementary to ictal and interictal electrical source imaging in the pediatric epilepsy surgical workup, guiding electrode placement for intracranial monitoring to identify the epileptogenic zone. |
| format | Article |
| id | doaj-art-87e403a995394426a2f8d6d02eb6d782 |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-87e403a995394426a2f8d6d02eb6d7822025-08-20T02:37:10ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-12-011510.3389/fneur.2024.14839771483977Low-density scalp electrical source imaging of the ictal onset zone network using source coherence mapsParnia Sadeghzadeh0Alexander Freibauer1Rajesh RamachandranNair2Robyn Whitney3Mutaz Al Nassar4Puneet Jain5Elizabeth Donner6Ayako Ochi7Kevin C. Jones8Division of Neurology, Department of Pediatrics, McMaster Children’s Hospital, Hamilton, ON, CanadaDivision of Neurology, Department of Pediatrics, BC Children’s Hospital, Vancouver, BC, CanadaDivision of Neurology, Department of Pediatrics, McMaster Children’s Hospital, Hamilton, ON, CanadaDivision of Neurology, Department of Pediatrics, McMaster Children’s Hospital, Hamilton, ON, CanadaDivision of Neuroimaging, Department of Diagnostic Imaging, McMaster Children’s Hospital, Hamilton, ON, CanadaDivision of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, CanadaDivision of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, CanadaDivision of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, CanadaDivision of Neurology, Department of Pediatrics, McMaster Children’s Hospital, Hamilton, ON, CanadaIntroductionThis study investigated low-density scalp electrical source imaging of the ictal onset zone and interictal spike ripple high-frequency oscillation networks using source coherence maps in the pediatric epilepsy surgical workup. Intracranial monitoring, the gold standard for determining epileptogenic zones, has limited spatial sampling. Source coherence analysis presents a promising new non-invasive technique.MethodsThis was a retrospective review of 12 patients who underwent focal resections. Source coherence maps were generated using standardized low-resolution electromagnetic tomography and concordance to resection margins was assessed, noting outcomes at 3 years post-surgery.ResultsIctal source coherence maps were performed in 7/12 patients. Six of seven included the surgical resection. Five of seven cases were seizure free post-resection. Interictal spike ripple electrical source imaging and interictal spike ripple high-frequency oscillation networks using source coherence maps were performed for three cases, with two of three included in the resection and all three were seizure free.DiscussionThese findings may provide proof of principle supporting low-density scalp electrical source imaging of the ictal onset zone and spike ripple network using source coherence maps. This promising method is complementary to ictal and interictal electrical source imaging in the pediatric epilepsy surgical workup, guiding electrode placement for intracranial monitoring to identify the epileptogenic zone.https://www.frontiersin.org/articles/10.3389/fneur.2024.1483977/fullelectrical source imagingictal onset zonesource coherence mapslow densityepilepsy surgery |
| spellingShingle | Parnia Sadeghzadeh Alexander Freibauer Rajesh RamachandranNair Robyn Whitney Mutaz Al Nassar Puneet Jain Elizabeth Donner Ayako Ochi Kevin C. Jones Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps Frontiers in Neurology electrical source imaging ictal onset zone source coherence maps low density epilepsy surgery |
| title | Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps |
| title_full | Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps |
| title_fullStr | Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps |
| title_full_unstemmed | Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps |
| title_short | Low-density scalp electrical source imaging of the ictal onset zone network using source coherence maps |
| title_sort | low density scalp electrical source imaging of the ictal onset zone network using source coherence maps |
| topic | electrical source imaging ictal onset zone source coherence maps low density epilepsy surgery |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1483977/full |
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