Predictors of Mortality among Adult Antiretroviral Therapy Users in Southeastern Ethiopia: Retrospective Cohort Study
Background. Although efforts have been made to reduce AIDS-related mortality by providing antiretroviral therapy (ART) services, still people are dying while they are on treatment due to several factors. This study aimed to investigate the predictors of mortality among adult antiretroviral therapy (...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2015/148769 |
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| author | Tesfaye Setegn Abulie Takele Tesfaye Gizaw Dabere Nigatu Demewoz Haile |
| author_facet | Tesfaye Setegn Abulie Takele Tesfaye Gizaw Dabere Nigatu Demewoz Haile |
| author_sort | Tesfaye Setegn |
| collection | DOAJ |
| description | Background. Although efforts have been made to reduce AIDS-related mortality by providing antiretroviral therapy (ART) services, still people are dying while they are on treatment due to several factors. This study aimed to investigate the predictors of mortality among adult antiretroviral therapy (ART) users in Goba Hospital, Southeast Ethiopia. Methods. The medical records of 2036 ART users who enrolled at Goba Hospital between 2007 and 2012 were reviewed and sociodemographic, clinical, and ART-related data were collected. Multivariable Cox proportional hazards regression model was used to measure risk of death and identify the independent predictors of mortality. Results. The overall mortality incidence rate was 20.3 deaths per 1000 person-years. Male, bedridden, overweight/obese, and HIV clients infected with TB and other infectious diseases had higher odds of death compared with their respective counterparts. On the other hand, ART clients with primary and secondary educational level and early and less advanced WHO clinical stage had lower odds of death compared to their counterparts. Conclusion. The overall mortality incidence rate was high and majority of the death had occurred in the first year of ART initiation. Intensifying and strengthening early ART initiation, improving nutritional status, prevention and control of TB, and other opportunistic infections are recommended interventions. |
| format | Article |
| id | doaj-art-87e386f5b99c45fd9ce4fc23bf58e767 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-87e386f5b99c45fd9ce4fc23bf58e7672025-08-20T03:38:05ZengWileyAIDS Research and Treatment2090-12402090-12592015-01-01201510.1155/2015/148769148769Predictors of Mortality among Adult Antiretroviral Therapy Users in Southeastern Ethiopia: Retrospective Cohort StudyTesfaye Setegn0Abulie Takele1Tesfaye Gizaw2Dabere Nigatu3Demewoz Haile4Department of Reproductive Health, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, EthiopiaDepartment of Nursing, College of Medicine and Health Sciences, Madawalabu University, P.O. Box 302, 1000 Bale Goba, EthiopiaDepartment of Medicine, College of Medicine and Health Sciences, Madawalabu University, P.O. Box 302, 1000 Bale Goba, EthiopiaDepartment of Nursing, College of Medicine and Health Sciences, Madawalabu University, P.O. Box 302, 1000 Bale Goba, EthiopiaDepartment of Public Health, College of Medicine and Health Sciences, Madawalabu University, P.O. Box 302, 1000 Bale Goba, EthiopiaBackground. Although efforts have been made to reduce AIDS-related mortality by providing antiretroviral therapy (ART) services, still people are dying while they are on treatment due to several factors. This study aimed to investigate the predictors of mortality among adult antiretroviral therapy (ART) users in Goba Hospital, Southeast Ethiopia. Methods. The medical records of 2036 ART users who enrolled at Goba Hospital between 2007 and 2012 were reviewed and sociodemographic, clinical, and ART-related data were collected. Multivariable Cox proportional hazards regression model was used to measure risk of death and identify the independent predictors of mortality. Results. The overall mortality incidence rate was 20.3 deaths per 1000 person-years. Male, bedridden, overweight/obese, and HIV clients infected with TB and other infectious diseases had higher odds of death compared with their respective counterparts. On the other hand, ART clients with primary and secondary educational level and early and less advanced WHO clinical stage had lower odds of death compared to their counterparts. Conclusion. The overall mortality incidence rate was high and majority of the death had occurred in the first year of ART initiation. Intensifying and strengthening early ART initiation, improving nutritional status, prevention and control of TB, and other opportunistic infections are recommended interventions.http://dx.doi.org/10.1155/2015/148769 |
| spellingShingle | Tesfaye Setegn Abulie Takele Tesfaye Gizaw Dabere Nigatu Demewoz Haile Predictors of Mortality among Adult Antiretroviral Therapy Users in Southeastern Ethiopia: Retrospective Cohort Study AIDS Research and Treatment |
| title | Predictors of Mortality among Adult Antiretroviral Therapy Users in Southeastern Ethiopia: Retrospective Cohort Study |
| title_full | Predictors of Mortality among Adult Antiretroviral Therapy Users in Southeastern Ethiopia: Retrospective Cohort Study |
| title_fullStr | Predictors of Mortality among Adult Antiretroviral Therapy Users in Southeastern Ethiopia: Retrospective Cohort Study |
| title_full_unstemmed | Predictors of Mortality among Adult Antiretroviral Therapy Users in Southeastern Ethiopia: Retrospective Cohort Study |
| title_short | Predictors of Mortality among Adult Antiretroviral Therapy Users in Southeastern Ethiopia: Retrospective Cohort Study |
| title_sort | predictors of mortality among adult antiretroviral therapy users in southeastern ethiopia retrospective cohort study |
| url | http://dx.doi.org/10.1155/2015/148769 |
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