Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics
Abstract Copper and iron are essential elements that play critical roles in several biological processes, including cancer cell survival and metabolism. Their dysregulation can cause cellular stress and malfunction, ultimately leading to regulated cell death (RCD). Recently, cuproptosis and ferropto...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03150-6 |
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| author | Prashant Chauhan Pratibha Pandey Ajay Singh Sujayaraj Samuel Jayakumar Sorabh Lakhanpal Meenakshi Verma Vijay Jagdish Upadhye Fahad Khan |
| author_facet | Prashant Chauhan Pratibha Pandey Ajay Singh Sujayaraj Samuel Jayakumar Sorabh Lakhanpal Meenakshi Verma Vijay Jagdish Upadhye Fahad Khan |
| author_sort | Prashant Chauhan |
| collection | DOAJ |
| description | Abstract Copper and iron are essential elements that play critical roles in several biological processes, including cancer cell survival and metabolism. Their dysregulation can cause cellular stress and malfunction, ultimately leading to regulated cell death (RCD). Recently, cuproptosis and ferroptosis have emerged as newly discovered RCDs, reflecting promising results in the context of cancer management. Unlike other RCDs, ferroptosis and cuproptosis have distinct morphological, genetic, and biological mechanisms. Accumulated iron-driven ferroptosis and copper-induced cuproptosis disturb several cellular processes by altering key proteins, signalling pathways, and cell cycles. These disruptions ultimately lead to mitochondrial dysfunction, formation of excessive reactive oxygen species (ROS), impairment of lipid layers, and modulation of immunological functions, altogether paving the direction towards cancer suppression and providing novel avenues towards targeted therapeutic strategies. Therefore, this study aimed to understand the fundamental mechanisms of ferroptosis and cuproptosis, especially in cancer cell mortality. Furthermore, this study highlights the multifaceted roles of phytocompounds, nanomedicines, and chemotherapeutic agents in inducing ferroptosis and cuproptosis. Thus, contributing to significant improvements in the development of cancer treatments. |
| format | Article |
| id | doaj-art-87e21696cfc044c4a67fd21365e84c0f |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-87e21696cfc044c4a67fd21365e84c0f2025-08-20T03:46:20ZengSpringerDiscover Oncology2730-60112025-07-0116111710.1007/s12672-025-03150-6Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeuticsPrashant Chauhan0Pratibha Pandey1Ajay Singh2Sujayaraj Samuel Jayakumar3Sorabh Lakhanpal4Meenakshi Verma5Vijay Jagdish Upadhye6Fahad Khan7MPA ResearchCentre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara UniversitySchool of Applied and Life Sciences, Uttaranchal UniversityDepartment of Forensic Science, School of Sciences, JAIN (Deemed to be University)School of Pharmaceutical Sciences, Lovely Professional UniversityUniversity Centre for Research and Development, Chandigarh UniversityResearch and Development Cell (RDC), Parul Institute of Applied Sciences (PIAS), Parul University (DSIR-SIRO Recognized)Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical SciencesAbstract Copper and iron are essential elements that play critical roles in several biological processes, including cancer cell survival and metabolism. Their dysregulation can cause cellular stress and malfunction, ultimately leading to regulated cell death (RCD). Recently, cuproptosis and ferroptosis have emerged as newly discovered RCDs, reflecting promising results in the context of cancer management. Unlike other RCDs, ferroptosis and cuproptosis have distinct morphological, genetic, and biological mechanisms. Accumulated iron-driven ferroptosis and copper-induced cuproptosis disturb several cellular processes by altering key proteins, signalling pathways, and cell cycles. These disruptions ultimately lead to mitochondrial dysfunction, formation of excessive reactive oxygen species (ROS), impairment of lipid layers, and modulation of immunological functions, altogether paving the direction towards cancer suppression and providing novel avenues towards targeted therapeutic strategies. Therefore, this study aimed to understand the fundamental mechanisms of ferroptosis and cuproptosis, especially in cancer cell mortality. Furthermore, this study highlights the multifaceted roles of phytocompounds, nanomedicines, and chemotherapeutic agents in inducing ferroptosis and cuproptosis. Thus, contributing to significant improvements in the development of cancer treatments.https://doi.org/10.1007/s12672-025-03150-6FerroptosisCuproptosisCell deathCancer therapyNatural compounds |
| spellingShingle | Prashant Chauhan Pratibha Pandey Ajay Singh Sujayaraj Samuel Jayakumar Sorabh Lakhanpal Meenakshi Verma Vijay Jagdish Upadhye Fahad Khan Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics Discover Oncology Ferroptosis Cuproptosis Cell death Cancer therapy Natural compounds |
| title | Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics |
| title_full | Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics |
| title_fullStr | Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics |
| title_full_unstemmed | Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics |
| title_short | Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics |
| title_sort | exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics |
| topic | Ferroptosis Cuproptosis Cell death Cancer therapy Natural compounds |
| url | https://doi.org/10.1007/s12672-025-03150-6 |
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