Alpha-Lipoic Acid and Metformin Combination Therapy Synergistically Activate Nrf2-AMPK Signaling Pathways to Ameliorate Cognitive Dysfunction in Type 2 Diabetic Encephalopathy: A Preclinical Study

Alpha-Lipoic Acid and Metformin Combination Therapy Synergistically Activate Nrf2-AMPK Signaling Pathways to Ameliorate Cognitive Dysfunction in Type 2 Diabetic Encephalopathy: A Preclinical Study

Diabetic encephalopathy affects over 40% of diabetic patients globally, yet effective treatments remain critically limited. This study investigated the synergistic neuroprotective potential of alpha-lipoic acid (ALA) and metformin through the coordinated activation of Nrf2 and AMPK signaling pathway...

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Bibliographic Details
Main Authors:	Abdulmajeed F. Alrefaei, Mohamed E. Elbeeh
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Biology
Subjects:	alpha-lipoic acid metformin synergistic therapy Nrf2 signaling AMPK pathway diabetic encephalopathy
Online Access:	https://www.mdpi.com/2079-7737/14/7/885
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