Single-cell transcriptomics and functional validation revealed PLEKHA5-L as a promoter of growth and migration in brain metastatic melanoma cells

Single-cell transcriptomics and functional validation revealed PLEKHA5-L as a promoter of growth and migration in brain metastatic melanoma cells

BackgroundMelanoma brain metastasis is an lethal event. Investigating the molecules that potentially promoted melanoma metastasis is important for targeted therapy.MethodsThe transcriptional profiles of totaling 7 melanoma samples, including 4 primary and 3 brain metastatic tissues were studied on t...

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Bibliographic Details
Main Authors: Xiaogen Tang, Tingting Lei, Boya Huang, Guangjie Wu, Yizhen Tian, Jian Xiang, Dongwei Fu, Hongyi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
melanoma
brain metastasis
PLEKHA5
single-cell RNA sequencing
PLEKHA-L
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1560954/full
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