Nanovaccines against Cervical Cancer: Reliable Strategies to Circumvent Limitations of Traditional Therapeutic Vaccines
Cervical cancer ranks fourth in terms of diagnosis and cancer-related deaths in women worldwide. Despite the approval of prophylactic vaccines against cervical cancers, these vaccines are not able to eradicate the existing ones. Therefore, various platforms have been developed to design therapeutic...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2025-04-01
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| Series: | Advanced Pharmaceutical Bulletin |
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| Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-15-46.pdf |
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| author | Enwa Felix Oghenemaro Safia Obaidur Rab Ebraheem Abdu Musad Saleh Asmaa F. Kassem Jasur Rizaev Deepak Nathiya Parjinder Kaur M. Ravi Kumar Karam Kadhim Ahmed M. Hashim |
| author_facet | Enwa Felix Oghenemaro Safia Obaidur Rab Ebraheem Abdu Musad Saleh Asmaa F. Kassem Jasur Rizaev Deepak Nathiya Parjinder Kaur M. Ravi Kumar Karam Kadhim Ahmed M. Hashim |
| author_sort | Enwa Felix Oghenemaro |
| collection | DOAJ |
| description | Cervical cancer ranks fourth in terms of diagnosis and cancer-related deaths in women worldwide. Despite the approval of prophylactic vaccines against cervical cancers, these vaccines are not able to eradicate the existing ones. Therefore, various platforms have been developed to design therapeutic vaccines against cervical cancers, including DNA/RNA-based, protein/peptide-based, vector-based, and cell-based platforms. Despite the advantages of each platform, therapeutic vaccines have displayed limited clinical benefit in patients with cervical cancer, which is partially associated with inefficient delivery of vaccine components. To address these issues, different nanoplatforms have been developed to carry cellular or molecular components of vaccines to target cells and lymphoid tissues, thus promoting the durability and potency of immune responses against tumor cells and antigens besides decreasing side effects. Moreover, nanoparticles (NPs), as adjuvants and/or carriers, provide other advantages, including sufficient antigen loading and uptake by antigen-presenting cells (APCs), adaptable antigen presentation, high immunogenicity, high stability, increased lymph node retention, and precise targeting. Thus, nanovaccines also lead us to design and develop personalized vaccines against cervical cancer. Here, we discuss platforms that have been used in clinical trials for the treatment of cervical cancer, their advantages and disadvantages, platforms for developing nanovaccines, and how they improve the therapeutic efficacy of vaccines. |
| format | Article |
| id | doaj-art-87d2510694fa4e8fb9414b324f9ba21f |
| institution | DOAJ |
| issn | 2228-5881 2251-7308 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj-art-87d2510694fa4e8fb9414b324f9ba21f2025-08-20T02:41:33ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082025-04-01151465910.34172/apb.43712apb-43712Nanovaccines against Cervical Cancer: Reliable Strategies to Circumvent Limitations of Traditional Therapeutic VaccinesEnwa Felix Oghenemaro0Safia Obaidur Rab1Ebraheem Abdu Musad Saleh2Asmaa F. Kassem3Jasur Rizaev4Deepak Nathiya5Parjinder Kaur6M. Ravi Kumar7Karam Kadhim8Ahmed M. Hashim9Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Delta State University, Abraka, Delta State, Nigeria.Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid and University, Abha, Saudi Arabia.Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.Department of Public Health and Healthcare Management, Rector, Samarkand State Medical University, 18, Amir Temur Street, Samarkand, Uzbekistan.Department of Pharmacy Practice, NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, India.Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali 140307, Punjab, India.Department of Basic Science & Humanities, Raghu Engineering College, Visakhapatnam, India.Medical Laboratory Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, Babylon, Iraq.Mazaya University College, Dhiqar, Iraq.Cervical cancer ranks fourth in terms of diagnosis and cancer-related deaths in women worldwide. Despite the approval of prophylactic vaccines against cervical cancers, these vaccines are not able to eradicate the existing ones. Therefore, various platforms have been developed to design therapeutic vaccines against cervical cancers, including DNA/RNA-based, protein/peptide-based, vector-based, and cell-based platforms. Despite the advantages of each platform, therapeutic vaccines have displayed limited clinical benefit in patients with cervical cancer, which is partially associated with inefficient delivery of vaccine components. To address these issues, different nanoplatforms have been developed to carry cellular or molecular components of vaccines to target cells and lymphoid tissues, thus promoting the durability and potency of immune responses against tumor cells and antigens besides decreasing side effects. Moreover, nanoparticles (NPs), as adjuvants and/or carriers, provide other advantages, including sufficient antigen loading and uptake by antigen-presenting cells (APCs), adaptable antigen presentation, high immunogenicity, high stability, increased lymph node retention, and precise targeting. Thus, nanovaccines also lead us to design and develop personalized vaccines against cervical cancer. Here, we discuss platforms that have been used in clinical trials for the treatment of cervical cancer, their advantages and disadvantages, platforms for developing nanovaccines, and how they improve the therapeutic efficacy of vaccines.https://apb.tbzmed.ac.ir/PDF/apb-15-46.pdfcervical cancertherapeutic vaccinenanotechnologyimmune responsenanovaccine |
| spellingShingle | Enwa Felix Oghenemaro Safia Obaidur Rab Ebraheem Abdu Musad Saleh Asmaa F. Kassem Jasur Rizaev Deepak Nathiya Parjinder Kaur M. Ravi Kumar Karam Kadhim Ahmed M. Hashim Nanovaccines against Cervical Cancer: Reliable Strategies to Circumvent Limitations of Traditional Therapeutic Vaccines Advanced Pharmaceutical Bulletin cervical cancer therapeutic vaccine nanotechnology immune response nanovaccine |
| title | Nanovaccines against Cervical Cancer: Reliable Strategies to Circumvent Limitations of Traditional Therapeutic Vaccines |
| title_full | Nanovaccines against Cervical Cancer: Reliable Strategies to Circumvent Limitations of Traditional Therapeutic Vaccines |
| title_fullStr | Nanovaccines against Cervical Cancer: Reliable Strategies to Circumvent Limitations of Traditional Therapeutic Vaccines |
| title_full_unstemmed | Nanovaccines against Cervical Cancer: Reliable Strategies to Circumvent Limitations of Traditional Therapeutic Vaccines |
| title_short | Nanovaccines against Cervical Cancer: Reliable Strategies to Circumvent Limitations of Traditional Therapeutic Vaccines |
| title_sort | nanovaccines against cervical cancer reliable strategies to circumvent limitations of traditional therapeutic vaccines |
| topic | cervical cancer therapeutic vaccine nanotechnology immune response nanovaccine |
| url | https://apb.tbzmed.ac.ir/PDF/apb-15-46.pdf |
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