Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp
Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this...
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/5596876 |
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| author | Carmen M. Sandoval Pacheco Gabriela V. Araujo Flores Kadir Gonzalez Claudia M. de Castro Gomes Luiz F. D. Passero Thaise Y. Tomokane Wilfredo Sosa-Ochoa Concepción Zúniga Jose Calzada Azael Saldaña Carlos E. P. Corbett Fernando T. Silveira Marcia D. Laurenti |
| author_facet | Carmen M. Sandoval Pacheco Gabriela V. Araujo Flores Kadir Gonzalez Claudia M. de Castro Gomes Luiz F. D. Passero Thaise Y. Tomokane Wilfredo Sosa-Ochoa Concepción Zúniga Jose Calzada Azael Saldaña Carlos E. P. Corbett Fernando T. Silveira Marcia D. Laurenti |
| author_sort | Carmen M. Sandoval Pacheco |
| collection | DOAJ |
| description | Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. In the present study, M1 and M2 macrophage subsets were analyzed by double-staining immunohistochemistry in skin biopsies from patients with American cutaneous leishmaniasis (ACL) caused by L. (L.) amazonensis, L. (V.) braziliensis, L. (V.) panamensis ,and L. (L.) infantum chagasi. High number of M1 macrophages was detected in nonulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi (M1=112±12, M2=43±12 cells/mm2). On the other side, high density of M2 macrophages was observed in the skin lesions of patients with anergic diffuse cutaneous leishmaniasis (ADCL) (M1=195±25, M2=616±114), followed by cases of localized cutaneous leishmaniasis (LCL) caused by L. (L.) amazonensis (M1=97±24, M2=219±29), L. (V.) panamensis (M1=71±14, M2=164±14), and L. (V.) braziliensis (M1=50±13, M2=53±10); however, low density of M2 macrophages was observed in NUCL. The data presented herein show the polarization of macrophages in skin lesions caused by different Leishmania species that may be related with the outcome of the disease. |
| format | Article |
| id | doaj-art-87cab9a2067b4fb1baa24d5d4b02121c |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-87cab9a2067b4fb1baa24d5d4b02121c2025-08-20T03:38:05ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/55968765596876Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania spCarmen M. Sandoval Pacheco0Gabriela V. Araujo Flores1Kadir Gonzalez2Claudia M. de Castro Gomes3Luiz F. D. Passero4Thaise Y. Tomokane5Wilfredo Sosa-Ochoa6Concepción Zúniga7Jose Calzada8Azael Saldaña9Carlos E. P. Corbett10Fernando T. Silveira11Marcia D. Laurenti12Departamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, BrazilDepartamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, BrazilDepartamento de Parasitología Molecular, Instituto Conmemorativo Gorgas de Estudios de la Salud, Ave. Justo Arosemena, 0816-02593 Calidonia, PanamaDepartamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, BrazilSão Paulo State University (UNESP), Institute of Biosciences and Institute for Advanced Studies of Ocean, São Vicente, SP, BrazilDepartamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, BrazilDepartamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, BrazilDepartamento de Vigilancia de la Salud, Hospital Escuela, Tegucigalpa, HondurasDepartamento de Parasitología Molecular, Instituto Conmemorativo Gorgas de Estudios de la Salud, Ave. Justo Arosemena, 0816-02593 Calidonia, PanamaDepartamento de Parasitología Molecular, Instituto Conmemorativo Gorgas de Estudios de la Salud, Ave. Justo Arosemena, 0816-02593 Calidonia, PanamaDepartamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, BrazilDepartamento de Parasitologia, Instituto Evandro Chagas, Belém, PA, BrazilDepartamento de Patologia, Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, Av. Doutor Arnaldo 455, 01246-903, Cerqueira César, São Paulo, SP, BrazilMacrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. In the present study, M1 and M2 macrophage subsets were analyzed by double-staining immunohistochemistry in skin biopsies from patients with American cutaneous leishmaniasis (ACL) caused by L. (L.) amazonensis, L. (V.) braziliensis, L. (V.) panamensis ,and L. (L.) infantum chagasi. High number of M1 macrophages was detected in nonulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi (M1=112±12, M2=43±12 cells/mm2). On the other side, high density of M2 macrophages was observed in the skin lesions of patients with anergic diffuse cutaneous leishmaniasis (ADCL) (M1=195±25, M2=616±114), followed by cases of localized cutaneous leishmaniasis (LCL) caused by L. (L.) amazonensis (M1=97±24, M2=219±29), L. (V.) panamensis (M1=71±14, M2=164±14), and L. (V.) braziliensis (M1=50±13, M2=53±10); however, low density of M2 macrophages was observed in NUCL. The data presented herein show the polarization of macrophages in skin lesions caused by different Leishmania species that may be related with the outcome of the disease.http://dx.doi.org/10.1155/2021/5596876 |
| spellingShingle | Carmen M. Sandoval Pacheco Gabriela V. Araujo Flores Kadir Gonzalez Claudia M. de Castro Gomes Luiz F. D. Passero Thaise Y. Tomokane Wilfredo Sosa-Ochoa Concepción Zúniga Jose Calzada Azael Saldaña Carlos E. P. Corbett Fernando T. Silveira Marcia D. Laurenti Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp Journal of Immunology Research |
| title | Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp |
| title_full | Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp |
| title_fullStr | Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp |
| title_full_unstemmed | Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp |
| title_short | Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp |
| title_sort | macrophage polarization in the skin lesion caused by neotropical species of leishmania sp |
| url | http://dx.doi.org/10.1155/2021/5596876 |
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