Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study
Abstract Background Cervical cancer is the 4th most prevalent cancer among females globally. In India, approximately 123,907 women are diagnosed with cervical cancer every year, leading to 77,348 deaths annually. However, Indian healthcare system lacks the sufficient information regarding the factor...
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SpringerOpen
2025-02-01
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| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
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| Online Access: | https://doi.org/10.1186/s43088-025-00602-4 |
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| author | Shaba Muneeha Raushan Kumar Chaudhary Vijith Vittal Shetty Soumya Patil Uday Venkat Mateti |
| author_facet | Shaba Muneeha Raushan Kumar Chaudhary Vijith Vittal Shetty Soumya Patil Uday Venkat Mateti |
| author_sort | Shaba Muneeha |
| collection | DOAJ |
| description | Abstract Background Cervical cancer is the 4th most prevalent cancer among females globally. In India, approximately 123,907 women are diagnosed with cervical cancer every year, leading to 77,348 deaths annually. However, Indian healthcare system lacks the sufficient information regarding the factors influencing survival and mortality among cervical cancer patients at regional levels. Thus, we aimed to identify the predictors associated with survival outcomes and mortality rates among cervical cancer. Methods A retrospective cohort study was conducted over 8 months at a tertiary care hospital where 10-year (January 2013–December 2022) data of cervical cancer patients were analyzed from medical record department (MRD). Telephonic interviews were carried out with patients or patient parties to know the survival status of patients. The data was analyzed using descriptive statistics, Kaplan–Meier curve, log-rank test and Cox regression. Results Out of 330 cervical cancer patients, majority (64.24%) were > 50 years of age followed by 35.76% were < 50 years. Most of the patients had abnormal body mass index (BMI) (46.96%), postmenopausal stage (75.76%), stage II cancer (43.03%), histologically poorly differentiated grade (47.88%) and squamous cell carcinoma (87.88%), with radiation plus chemotherapy being popular treatment choice (48.79%) and with the overall mean age of 56 years. Age, BMI, menopause, stage of cancer, histological grades and types of treatment were found to be significant predictors (p < 0.05) of survival among cervical cancer patients. Using cox regression analysis, advanced age (age > 50 years: hazard ratio (HR): 1.82), underweight (BMI < 18.5: HR:1), postmenopause (HR:1), advanced stage of cervical cancer (Stage I, Stage II, Stage III, Stage IV: HR:1, HR:2.78, HR:10.08, HR:20.81), poorly differentiated cervical cancer (HR:1.70), radiation therapy (HR:4.86), chemotherapy (HR:6.55) or chemoradiation therapy (HR:3.31) and surgery plus chemotherapy (HR: 4.55) were identified to be significant predictors of mortality among cervical cancer patients. Conclusion We conclude that the 5- and 10-year survival rates for cervical cancer patients were found to be 51.2% and 42.9%, respectively. Advanced age, underweight, postmenopausal status, advanced cancer stage, poor cancer cell differentiation and chemotherapy-based treatment were significant predictor of mortality and vice-versa for survival which might guide clinicians and policymakers in making informed clinical decisions to combat cervical cancer. |
| format | Article |
| id | doaj-art-87be9a3fcb484c0cb1b0eda917fb1975 |
| institution | Kabale University |
| issn | 2314-8543 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj-art-87be9a3fcb484c0cb1b0eda917fb19752025-02-09T12:49:57ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85432025-02-0114111110.1186/s43088-025-00602-4Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective studyShaba Muneeha0Raushan Kumar Chaudhary1Vijith Vittal Shetty2Soumya Patil3Uday Venkat Mateti4Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University)Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University)Department Medical Oncology, KS Hegde Medical Academy (KSHEMA), Justice KS Hegde Charitable Hospital, Nitte (Deemed to be University)Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University)Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University)Abstract Background Cervical cancer is the 4th most prevalent cancer among females globally. In India, approximately 123,907 women are diagnosed with cervical cancer every year, leading to 77,348 deaths annually. However, Indian healthcare system lacks the sufficient information regarding the factors influencing survival and mortality among cervical cancer patients at regional levels. Thus, we aimed to identify the predictors associated with survival outcomes and mortality rates among cervical cancer. Methods A retrospective cohort study was conducted over 8 months at a tertiary care hospital where 10-year (January 2013–December 2022) data of cervical cancer patients were analyzed from medical record department (MRD). Telephonic interviews were carried out with patients or patient parties to know the survival status of patients. The data was analyzed using descriptive statistics, Kaplan–Meier curve, log-rank test and Cox regression. Results Out of 330 cervical cancer patients, majority (64.24%) were > 50 years of age followed by 35.76% were < 50 years. Most of the patients had abnormal body mass index (BMI) (46.96%), postmenopausal stage (75.76%), stage II cancer (43.03%), histologically poorly differentiated grade (47.88%) and squamous cell carcinoma (87.88%), with radiation plus chemotherapy being popular treatment choice (48.79%) and with the overall mean age of 56 years. Age, BMI, menopause, stage of cancer, histological grades and types of treatment were found to be significant predictors (p < 0.05) of survival among cervical cancer patients. Using cox regression analysis, advanced age (age > 50 years: hazard ratio (HR): 1.82), underweight (BMI < 18.5: HR:1), postmenopause (HR:1), advanced stage of cervical cancer (Stage I, Stage II, Stage III, Stage IV: HR:1, HR:2.78, HR:10.08, HR:20.81), poorly differentiated cervical cancer (HR:1.70), radiation therapy (HR:4.86), chemotherapy (HR:6.55) or chemoradiation therapy (HR:3.31) and surgery plus chemotherapy (HR: 4.55) were identified to be significant predictors of mortality among cervical cancer patients. Conclusion We conclude that the 5- and 10-year survival rates for cervical cancer patients were found to be 51.2% and 42.9%, respectively. Advanced age, underweight, postmenopausal status, advanced cancer stage, poor cancer cell differentiation and chemotherapy-based treatment were significant predictor of mortality and vice-versa for survival which might guide clinicians and policymakers in making informed clinical decisions to combat cervical cancer.https://doi.org/10.1186/s43088-025-00602-4Cervical cancerMortalityPredictorsRetrospectiveSurvival |
| spellingShingle | Shaba Muneeha Raushan Kumar Chaudhary Vijith Vittal Shetty Soumya Patil Uday Venkat Mateti Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study Beni-Suef University Journal of Basic and Applied Sciences Cervical cancer Mortality Predictors Retrospective Survival |
| title | Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study |
| title_full | Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study |
| title_fullStr | Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study |
| title_full_unstemmed | Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study |
| title_short | Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study |
| title_sort | exploring and detecting predictors associated with survival and mortality of cervical cancer patients a 10 year retrospective study |
| topic | Cervical cancer Mortality Predictors Retrospective Survival |
| url | https://doi.org/10.1186/s43088-025-00602-4 |
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