Insights into the molecular and genetic role of obesity in breast cancer pathogenesis
The epidemic of obesity is a growing concern and is one of the major risk factors for several chronic diseases, including several types of cancers. The correlation of breast cancer with obesity has been extensively studied and involves an interplay of hormonal, metabolic, and genetic factors explore...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Cancer Biology & Therapy |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2025.2501345 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850189344296402944 |
|---|---|
| author | Sandeep Mallya Varsha Gangadhar Sophia Evangeline Aldrin Meghana Acharya Shama Prasada Kabekkodu Kiran Kumar Kolathur Sanjiban Chakrabarty |
| author_facet | Sandeep Mallya Varsha Gangadhar Sophia Evangeline Aldrin Meghana Acharya Shama Prasada Kabekkodu Kiran Kumar Kolathur Sanjiban Chakrabarty |
| author_sort | Sandeep Mallya |
| collection | DOAJ |
| description | The epidemic of obesity is a growing concern and is one of the major risk factors for several chronic diseases, including several types of cancers. The correlation of breast cancer with obesity has been extensively studied and involves an interplay of hormonal, metabolic, and genetic factors explored in this review. Inflammation and hormone dysregulation play an important role in promoting a protumorigenic environment through adipose tissue, which is involved in energy storage and functions as an endocrine organ. As a result, various cytokines, primarily proinflammatory in nature, are released, resulting in low-grade inflammation promoting tumor growth. Additionally, obese conditions also induce imbalances in hormones, particularly estrogen and insulin, both of which drive carcinogenesis. Genetic components such as single nucleotide polymorphisms also play critical roles in modulating the correlation between obesity and breast cancer. This review provides a comprehensive overview of various mechanisms underlying obesity and breast cancer incidence and progression. |
| format | Article |
| id | doaj-art-87b717a8ba6245dab8b0275fa48a3d1c |
| institution | OA Journals |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-87b717a8ba6245dab8b0275fa48a3d1c2025-08-20T02:15:38ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762025-12-0126110.1080/15384047.2025.2501345Insights into the molecular and genetic role of obesity in breast cancer pathogenesisSandeep Mallya0Varsha Gangadhar1Sophia Evangeline Aldrin2Meghana Acharya3Shama Prasada Kabekkodu4Kiran Kumar Kolathur5Sanjiban Chakrabarty6Department of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Public Health and Genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, IndiaThe epidemic of obesity is a growing concern and is one of the major risk factors for several chronic diseases, including several types of cancers. The correlation of breast cancer with obesity has been extensively studied and involves an interplay of hormonal, metabolic, and genetic factors explored in this review. Inflammation and hormone dysregulation play an important role in promoting a protumorigenic environment through adipose tissue, which is involved in energy storage and functions as an endocrine organ. As a result, various cytokines, primarily proinflammatory in nature, are released, resulting in low-grade inflammation promoting tumor growth. Additionally, obese conditions also induce imbalances in hormones, particularly estrogen and insulin, both of which drive carcinogenesis. Genetic components such as single nucleotide polymorphisms also play critical roles in modulating the correlation between obesity and breast cancer. This review provides a comprehensive overview of various mechanisms underlying obesity and breast cancer incidence and progression.https://www.tandfonline.com/doi/10.1080/15384047.2025.2501345Obesitybreast cancermolecular subtypes of cancerepidemichormonal imbalancebreast cancer pathogenesis |
| spellingShingle | Sandeep Mallya Varsha Gangadhar Sophia Evangeline Aldrin Meghana Acharya Shama Prasada Kabekkodu Kiran Kumar Kolathur Sanjiban Chakrabarty Insights into the molecular and genetic role of obesity in breast cancer pathogenesis Cancer Biology & Therapy Obesity breast cancer molecular subtypes of cancer epidemic hormonal imbalance breast cancer pathogenesis |
| title | Insights into the molecular and genetic role of obesity in breast cancer pathogenesis |
| title_full | Insights into the molecular and genetic role of obesity in breast cancer pathogenesis |
| title_fullStr | Insights into the molecular and genetic role of obesity in breast cancer pathogenesis |
| title_full_unstemmed | Insights into the molecular and genetic role of obesity in breast cancer pathogenesis |
| title_short | Insights into the molecular and genetic role of obesity in breast cancer pathogenesis |
| title_sort | insights into the molecular and genetic role of obesity in breast cancer pathogenesis |
| topic | Obesity breast cancer molecular subtypes of cancer epidemic hormonal imbalance breast cancer pathogenesis |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2025.2501345 |
| work_keys_str_mv | AT sandeepmallya insightsintothemolecularandgeneticroleofobesityinbreastcancerpathogenesis AT varshagangadhar insightsintothemolecularandgeneticroleofobesityinbreastcancerpathogenesis AT sophiaevangelinealdrin insightsintothemolecularandgeneticroleofobesityinbreastcancerpathogenesis AT meghanaacharya insightsintothemolecularandgeneticroleofobesityinbreastcancerpathogenesis AT shamaprasadakabekkodu insightsintothemolecularandgeneticroleofobesityinbreastcancerpathogenesis AT kirankumarkolathur insightsintothemolecularandgeneticroleofobesityinbreastcancerpathogenesis AT sanjibanchakrabarty insightsintothemolecularandgeneticroleofobesityinbreastcancerpathogenesis |