D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices.
Animal models are commonly used in brain ageing research. Amongst these, models where rodents are exposed to d-galactose are held to recapitulate a number of features of ageing including neurobehavioral and neurochemical changes. However, results from animal studies are often inconsistent. To better...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0184122 |
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| author | Saeed Sadigh-Eteghad Alireza Majdi Sarah K McCann Javad Mahmoudi Manouchehr S Vafaee Malcolm R Macleod |
| author_facet | Saeed Sadigh-Eteghad Alireza Majdi Sarah K McCann Javad Mahmoudi Manouchehr S Vafaee Malcolm R Macleod |
| author_sort | Saeed Sadigh-Eteghad |
| collection | DOAJ |
| description | Animal models are commonly used in brain ageing research. Amongst these, models where rodents are exposed to d-galactose are held to recapitulate a number of features of ageing including neurobehavioral and neurochemical changes. However, results from animal studies are often inconsistent. To better understand the characteristics of the model and effects of d-galactose on neurobehavioral and neurochemical outcomes in rodents we performed a systematic review and meta-analysis. We applied random-effects meta-analysis to evaluate the effect of study features. Our results give an overview of the characteristics of the d-galactose rodent ageing model, including neurobehavioral and neurochemical outcomes. We found that few studies took measures to reduce risks of bias, and substantial heterogeneity in the reported effects of d-galactose in included studies. This highlights the need for improvements in the use of the d-galactose rodent ageing model if it is to provide useful in the development of drugs to treat human ageing. |
| format | Article |
| id | doaj-art-87abc602a82f4d6d85fd111b4318751d |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-87abc602a82f4d6d85fd111b4318751d2025-08-20T03:26:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018412210.1371/journal.pone.0184122D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices.Saeed Sadigh-EteghadAlireza MajdiSarah K McCannJavad MahmoudiManouchehr S VafaeeMalcolm R MacleodAnimal models are commonly used in brain ageing research. Amongst these, models where rodents are exposed to d-galactose are held to recapitulate a number of features of ageing including neurobehavioral and neurochemical changes. However, results from animal studies are often inconsistent. To better understand the characteristics of the model and effects of d-galactose on neurobehavioral and neurochemical outcomes in rodents we performed a systematic review and meta-analysis. We applied random-effects meta-analysis to evaluate the effect of study features. Our results give an overview of the characteristics of the d-galactose rodent ageing model, including neurobehavioral and neurochemical outcomes. We found that few studies took measures to reduce risks of bias, and substantial heterogeneity in the reported effects of d-galactose in included studies. This highlights the need for improvements in the use of the d-galactose rodent ageing model if it is to provide useful in the development of drugs to treat human ageing.https://doi.org/10.1371/journal.pone.0184122 |
| spellingShingle | Saeed Sadigh-Eteghad Alireza Majdi Sarah K McCann Javad Mahmoudi Manouchehr S Vafaee Malcolm R Macleod D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices. PLoS ONE |
| title | D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices. |
| title_full | D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices. |
| title_fullStr | D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices. |
| title_full_unstemmed | D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices. |
| title_short | D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices. |
| title_sort | d galactose induced brain ageing model a systematic review and meta analysis on cognitive outcomes and oxidative stress indices |
| url | https://doi.org/10.1371/journal.pone.0184122 |
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