Circovirus Rep evades immune restriction by disrupting cGAS oligomerization and phase separation.

Circovirus Rep evades immune restriction by disrupting cGAS oligomerization and phase separation.

Cyclic GMP-AMP synthase (cGAS) is a key sensor of double-stranded DNA (dsDNA), initiating oligomerization and phase separation to drive immune responses against pathogens and endogenous damage. Porcine circovirus (PCV) induces immunosuppression, heightening susceptibility to secondary infections, bu...

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Bibliographic Details
Main Authors: Hongyan Yin, Zhenchao Zhao, Ye Yuan, Minjie Li, Lvye Chai, Weiyu Qu, Yan Ya, Haiwei Wang, Xin Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013244
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