Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults
Abstract This study aimed to investigate the interactions between the Dietary approaches to stop hypertension (DASH) and the rs1501299 and rs6450176 SNPs in terms of cardiometabolic risk factors. This cross-sectional study was conducted on 387 adults (20–70 years old) residing in Yazd, Iran. The par...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87567-7 |
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| author | Mehdi Mollahosseini Zeinab Yazdanpanah Azadeh Nadjarzadeh Masoud Mirzaei Seyed Mehdi Kalantar Hamid Reza Ashrafzadeh Khadijeh Mirzaei Hassan Mozaffari-Khosravi |
| author_facet | Mehdi Mollahosseini Zeinab Yazdanpanah Azadeh Nadjarzadeh Masoud Mirzaei Seyed Mehdi Kalantar Hamid Reza Ashrafzadeh Khadijeh Mirzaei Hassan Mozaffari-Khosravi |
| author_sort | Mehdi Mollahosseini |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the interactions between the Dietary approaches to stop hypertension (DASH) and the rs1501299 and rs6450176 SNPs in terms of cardiometabolic risk factors. This cross-sectional study was conducted on 387 adults (20–70 years old) residing in Yazd, Iran. The participants were selected from participants in the recruitment phase of the Yazd Health Study (YaHS) which is a population-based cohort of 9,962 adults. The genotypes of rs1501299 and rs6450176 SNPs were determined using the restriction fragment length polymorphism (RFLP) method. Unlike for the G allele carriers of rs1501299, high adherence to the DASH dietary pattern was related to the lower diastolic blood pressure (DBP; P-interaction = 0.014) and systolic blood pressure (SBP; P-interaction = 0.051) in the participants with TT genotype. Moreover, in individuals with the AA genotype of rs6450176 SNP, adherence to this diet was associated with lower SBP (P-interaction = 0.012), waist-to-hip ratio (WHR; P-interaction = 0.026) and waist-to-height ratio (WHtR; P-interaction = 0.040), while in G allele carriers, the mean of these items was greater in individuals with high adherence to the DASH diet. The results suggest that following the DASH diet may be related to lower blood pressure and central obesity indices only in individuals with TT genotype of rs1501299 and AA genotype of rs6450176, respectively, whereas it can be associated with higher WHR and WHtR in G allele carriers of rs6450176. |
| format | Article |
| id | doaj-art-87a5c28ee44c4f7094d6ad4dc47c41c6 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-87a5c28ee44c4f7094d6ad4dc47c41c62025-02-02T12:17:53ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-87567-7Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adultsMehdi Mollahosseini0Zeinab Yazdanpanah1Azadeh Nadjarzadeh2Masoud Mirzaei3Seyed Mehdi Kalantar4Hamid Reza Ashrafzadeh5Khadijeh Mirzaei6Hassan Mozaffari-Khosravi7Molecular and Medicine Research Center, Khomein University of Medical SciencesNutrition and Food Security Research Center, Shahid Sadoughi University of Medical SciencesNutrition and Food Security Research Center, Shahid Sadoughi University of Medical SciencesYazd Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical SciencesDepartment of Medical Genetics, Shahid Sadoughi University of Medical ScienceAbortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical SciencesDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS)Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical SciencesAbstract This study aimed to investigate the interactions between the Dietary approaches to stop hypertension (DASH) and the rs1501299 and rs6450176 SNPs in terms of cardiometabolic risk factors. This cross-sectional study was conducted on 387 adults (20–70 years old) residing in Yazd, Iran. The participants were selected from participants in the recruitment phase of the Yazd Health Study (YaHS) which is a population-based cohort of 9,962 adults. The genotypes of rs1501299 and rs6450176 SNPs were determined using the restriction fragment length polymorphism (RFLP) method. Unlike for the G allele carriers of rs1501299, high adherence to the DASH dietary pattern was related to the lower diastolic blood pressure (DBP; P-interaction = 0.014) and systolic blood pressure (SBP; P-interaction = 0.051) in the participants with TT genotype. Moreover, in individuals with the AA genotype of rs6450176 SNP, adherence to this diet was associated with lower SBP (P-interaction = 0.012), waist-to-hip ratio (WHR; P-interaction = 0.026) and waist-to-height ratio (WHtR; P-interaction = 0.040), while in G allele carriers, the mean of these items was greater in individuals with high adherence to the DASH diet. The results suggest that following the DASH diet may be related to lower blood pressure and central obesity indices only in individuals with TT genotype of rs1501299 and AA genotype of rs6450176, respectively, whereas it can be associated with higher WHR and WHtR in G allele carriers of rs6450176.https://doi.org/10.1038/s41598-025-87567-7ObesityDietCardiovascular diseasesBlood pressureHypertensionAdiponectin |
| spellingShingle | Mehdi Mollahosseini Zeinab Yazdanpanah Azadeh Nadjarzadeh Masoud Mirzaei Seyed Mehdi Kalantar Hamid Reza Ashrafzadeh Khadijeh Mirzaei Hassan Mozaffari-Khosravi Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults Scientific Reports Obesity Diet Cardiovascular diseases Blood pressure Hypertension Adiponectin |
| title | Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults |
| title_full | Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults |
| title_fullStr | Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults |
| title_full_unstemmed | Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults |
| title_short | Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults |
| title_sort | interactions between dash style diet and adipoq and arl15 genes polymorphisms on blood pressure and central obesity in iranian adults |
| topic | Obesity Diet Cardiovascular diseases Blood pressure Hypertension Adiponectin |
| url | https://doi.org/10.1038/s41598-025-87567-7 |
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