Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine
Precision medicine has revolutionized the field of neuroimmunology, with innovative approaches that characterize diseases based on their biology, deeper understanding of the factors leading to heterogeneity within the same disease, development of targeted therapies, and strategies to tailor therapie...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2023-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777752 |
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| author | Giordani Rodrigues dos Passos Tarso Adoni Maria Fernanda Mendes Douglas Kazutoshi Sato |
| author_facet | Giordani Rodrigues dos Passos Tarso Adoni Maria Fernanda Mendes Douglas Kazutoshi Sato |
| author_sort | Giordani Rodrigues dos Passos |
| collection | DOAJ |
| description | Precision medicine has revolutionized the field of neuroimmunology, with innovative approaches that characterize diseases based on their biology, deeper understanding of the factors leading to heterogeneity within the same disease, development of targeted therapies, and strategies to tailor therapies to each patient. This review explores the impact of precision medicine on various neuroimmunological conditions, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), optic neuritis, autoimmune encephalitis, and immune-mediated neuropathies. We discuss advances in disease subtyping, recognition of novel entities, promising biomarkers, and the development of more selective monoclonal antibodies and cutting-edge synthetic cell-based immunotherapies in neuroimmunological disorders. In addition, we analyze the challenges related to affordability and equity in the implementation of these emerging technologies, especially in situations with limited resources. |
| format | Article |
| id | doaj-art-87a3f720c58044a083829510da65ce89 |
| institution | OA Journals |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-87a3f720c58044a083829510da65ce892025-08-20T02:09:01ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272023-12-0181121125113310.1055/s-0043-1777752Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicineGiordani Rodrigues dos Passos0https://orcid.org/0000-0002-8949-6115Tarso Adoni1https://orcid.org/0000-0002-5008-2783Maria Fernanda Mendes2https://orcid.org/0000-0003-3983-6019Douglas Kazutoshi Sato3https://orcid.org/0000-0002-7695-6020Pontifícia Universidade Católica do Rio Grande do Sul, Escola de Medicina e Instituto do Cérebro do Rio Grande do Sul, Porto Alegre RS, Brazil.Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, São Paulo SP, Brazil.Santa Casa de São Paulo, Faculdade de Ciências Médicas, São Paulo SP, Brazil.Pontifícia Universidade Católica do Rio Grande do Sul, Escola de Medicina e Instituto do Cérebro do Rio Grande do Sul, Porto Alegre RS, Brazil.Precision medicine has revolutionized the field of neuroimmunology, with innovative approaches that characterize diseases based on their biology, deeper understanding of the factors leading to heterogeneity within the same disease, development of targeted therapies, and strategies to tailor therapies to each patient. This review explores the impact of precision medicine on various neuroimmunological conditions, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), optic neuritis, autoimmune encephalitis, and immune-mediated neuropathies. We discuss advances in disease subtyping, recognition of novel entities, promising biomarkers, and the development of more selective monoclonal antibodies and cutting-edge synthetic cell-based immunotherapies in neuroimmunological disorders. In addition, we analyze the challenges related to affordability and equity in the implementation of these emerging technologies, especially in situations with limited resources.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777752Precision MedicineAutoimmune Diseases of the Nervous SystemMultiple SclerosisNeuromyelitis OpticaBiomarkersImmunomodulationPharmacogeneticsMedicina de PrecisãoDoenças Autoimunes do Sistema NervosoEsclerose MúltiplaNeuromielite ÓpticaBiomarcadoresImunomodulaçãoFarmacogenética |
| spellingShingle | Giordani Rodrigues dos Passos Tarso Adoni Maria Fernanda Mendes Douglas Kazutoshi Sato Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine Arquivos de Neuro-Psiquiatria Precision Medicine Autoimmune Diseases of the Nervous System Multiple Sclerosis Neuromyelitis Optica Biomarkers Immunomodulation Pharmacogenetics Medicina de Precisão Doenças Autoimunes do Sistema Nervoso Esclerose Múltipla Neuromielite Óptica Biomarcadores Imunomodulação Farmacogenética |
| title | Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine |
| title_full | Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine |
| title_fullStr | Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine |
| title_full_unstemmed | Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine |
| title_short | Reshaping neuroimmunology: diagnosis and treatment in the era of precision medicine |
| title_sort | reshaping neuroimmunology diagnosis and treatment in the era of precision medicine |
| topic | Precision Medicine Autoimmune Diseases of the Nervous System Multiple Sclerosis Neuromyelitis Optica Biomarkers Immunomodulation Pharmacogenetics Medicina de Precisão Doenças Autoimunes do Sistema Nervoso Esclerose Múltipla Neuromielite Óptica Biomarcadores Imunomodulação Farmacogenética |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777752 |
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