Osteitis in Chronic Rhinosinusitis: A State-of-the-Art Review
Chronic rhinosinusitis (CRS) is characterized by inflammation of the nasal mucosa and paranasal sinuses. Mucosal inflammation can induce bone remodeling leading to osteitis. Paranasal sinus osteitis is a relatively new clinical finding, describing changes in the bone due to inflammation that will d...
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Faculty of Medicine Siriraj Hospital
2025-07-01
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| Series: | Siriraj Medical Journal |
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| Online Access: | https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/274010 |
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| author | Wiyono Hadi Widia Isa Aprillia Sujana |
| author_facet | Wiyono Hadi Widia Isa Aprillia Sujana |
| author_sort | Wiyono Hadi |
| collection | DOAJ |
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Chronic rhinosinusitis (CRS) is characterized by inflammation of the nasal mucosa and paranasal sinuses. Mucosal inflammation can induce bone remodeling leading to osteitis. Paranasal sinus osteitis is a relatively new clinical finding, describing changes in the bone due to inflammation that will damage the lamellar bone structure and new bone formation. As many as 36-53% of CRS patients have osteitis, which makes CRS difficult to cure despite adequate management and is related to a substantial number of revision surgeries. Understanding all the evidence regarding osteitis in CRS is critical in discovering effective treatments for this incurable disease. Hence, we summarize the essential yet well-established features of osteitis in CRS, including the updated definition, the role of biofilm formation along with cytokines and runt-related transcription factor 2 axis as its possible underlying pathogenesis, the transforming growth factor beta signaling pathway of the disease, histopathological bone changes, radiographic staging and scoring systems, disease impacts on the CRS severity and quality of life, as well as the most up-to-date treatment strategies for osteitis in CRS. These include functional or radical endoscopic sinus surgery, interleukin-13 inhibitors, anti-biofilm agents, high-dose intranasal corticosteroids, and other potential therapies.
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| format | Article |
| id | doaj-art-879e738ebc3b44f38ee7f1ed86c061e2 |
| institution | OA Journals |
| issn | 2228-8082 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Faculty of Medicine Siriraj Hospital |
| record_format | Article |
| series | Siriraj Medical Journal |
| spelling | doaj-art-879e738ebc3b44f38ee7f1ed86c061e22025-08-20T02:38:45ZengFaculty of Medicine Siriraj HospitalSiriraj Medical Journal2228-80822025-07-0177710.33192/smj.v77i7.274010Osteitis in Chronic Rhinosinusitis: A State-of-the-Art ReviewWiyono Hadi0Widia Isa Aprillia Sujana1Department of Otorhinolaryngology – Head and Neck Surgery, Faculty of Medicine, Universitas Katolik Widya Mandala Surabaya, Surabaya, IndonesiaDepartment of Otorhinolaryngology – Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia Chronic rhinosinusitis (CRS) is characterized by inflammation of the nasal mucosa and paranasal sinuses. Mucosal inflammation can induce bone remodeling leading to osteitis. Paranasal sinus osteitis is a relatively new clinical finding, describing changes in the bone due to inflammation that will damage the lamellar bone structure and new bone formation. As many as 36-53% of CRS patients have osteitis, which makes CRS difficult to cure despite adequate management and is related to a substantial number of revision surgeries. Understanding all the evidence regarding osteitis in CRS is critical in discovering effective treatments for this incurable disease. Hence, we summarize the essential yet well-established features of osteitis in CRS, including the updated definition, the role of biofilm formation along with cytokines and runt-related transcription factor 2 axis as its possible underlying pathogenesis, the transforming growth factor beta signaling pathway of the disease, histopathological bone changes, radiographic staging and scoring systems, disease impacts on the CRS severity and quality of life, as well as the most up-to-date treatment strategies for osteitis in CRS. These include functional or radical endoscopic sinus surgery, interleukin-13 inhibitors, anti-biofilm agents, high-dose intranasal corticosteroids, and other potential therapies. https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/274010Bone remodelingchronic rhinosinusitishyperostosisneo-osteogenesisosteitis |
| spellingShingle | Wiyono Hadi Widia Isa Aprillia Sujana Osteitis in Chronic Rhinosinusitis: A State-of-the-Art Review Siriraj Medical Journal Bone remodeling chronic rhinosinusitis hyperostosis neo-osteogenesis osteitis |
| title | Osteitis in Chronic Rhinosinusitis: A State-of-the-Art Review |
| title_full | Osteitis in Chronic Rhinosinusitis: A State-of-the-Art Review |
| title_fullStr | Osteitis in Chronic Rhinosinusitis: A State-of-the-Art Review |
| title_full_unstemmed | Osteitis in Chronic Rhinosinusitis: A State-of-the-Art Review |
| title_short | Osteitis in Chronic Rhinosinusitis: A State-of-the-Art Review |
| title_sort | osteitis in chronic rhinosinusitis a state of the art review |
| topic | Bone remodeling chronic rhinosinusitis hyperostosis neo-osteogenesis osteitis |
| url | https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/274010 |
| work_keys_str_mv | AT wiyonohadi osteitisinchronicrhinosinusitisastateoftheartreview AT widiaisaaprilliasujana osteitisinchronicrhinosinusitisastateoftheartreview |