The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices
Diabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients. In the present study, the effects of Angipars on nerve conduction velocity, histological alterations...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/721547 |
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| author | Nasser Zangiabadi Hossein Mohtashami Mahboobeh Hojatipour Mandana Jafari Majid Asadi-Shekaari Mohammad Shabani |
| author_facet | Nasser Zangiabadi Hossein Mohtashami Mahboobeh Hojatipour Mandana Jafari Majid Asadi-Shekaari Mohammad Shabani |
| author_sort | Nasser Zangiabadi |
| collection | DOAJ |
| description | Diabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients. In the present study, the effects of Angipars on nerve conduction velocity, histological alterations, and behavioral indices were investigated. Diabetes was induced in male rats by intraperitoneal injection of streptozotocin (STZ). Six weeks after STZ injection, animals were divided into five groups control, vehicle, and 3 experimental groups. The vehicle group received 1 mL distilled water daily for two weeks and three experimental groups received, respectively, intraperitoneal injection of 5, 10, and 20 mg/kg Angipars daily for two weeks. Intraperitoneal injection of Angipars, in some extent, could significantly improve behavioral indices of the experimental groups as compared to the vehicle group. Furthermore, mean nerve conduction velocity in the vehicle group showed significant difference with that in the control and the 2nd experimental groups; therefore, Angipars could increase nerve conduction velocity in neuropathic rats. Overall, Angipars exerted positive effects on the treatment and reduction of physiologic symptoms and improvement of sciatic morphological injuries in neuropathic rats. |
| format | Article |
| id | doaj-art-879d0d073821410095724fa3e22ff999 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-879d0d073821410095724fa3e22ff9992025-02-03T05:45:02ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/721547721547The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural IndicesNasser Zangiabadi0Hossein Mohtashami1Mahboobeh Hojatipour2Mandana Jafari3Majid Asadi-Shekaari4Mohammad Shabani5Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Tahmassebabad Crossroad, Ebne-Sina Street, Kerman 76198-13159, IranNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Tahmassebabad Crossroad, Ebne-Sina Street, Kerman 76198-13159, IranNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Tahmassebabad Crossroad, Ebne-Sina Street, Kerman 76198-13159, IranNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Tahmassebabad Crossroad, Ebne-Sina Street, Kerman 76198-13159, IranNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Tahmassebabad Crossroad, Ebne-Sina Street, Kerman 76198-13159, IranNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Tahmassebabad Crossroad, Ebne-Sina Street, Kerman 76198-13159, IranDiabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients. In the present study, the effects of Angipars on nerve conduction velocity, histological alterations, and behavioral indices were investigated. Diabetes was induced in male rats by intraperitoneal injection of streptozotocin (STZ). Six weeks after STZ injection, animals were divided into five groups control, vehicle, and 3 experimental groups. The vehicle group received 1 mL distilled water daily for two weeks and three experimental groups received, respectively, intraperitoneal injection of 5, 10, and 20 mg/kg Angipars daily for two weeks. Intraperitoneal injection of Angipars, in some extent, could significantly improve behavioral indices of the experimental groups as compared to the vehicle group. Furthermore, mean nerve conduction velocity in the vehicle group showed significant difference with that in the control and the 2nd experimental groups; therefore, Angipars could increase nerve conduction velocity in neuropathic rats. Overall, Angipars exerted positive effects on the treatment and reduction of physiologic symptoms and improvement of sciatic morphological injuries in neuropathic rats.http://dx.doi.org/10.1155/2014/721547 |
| spellingShingle | Nasser Zangiabadi Hossein Mohtashami Mahboobeh Hojatipour Mandana Jafari Majid Asadi-Shekaari Mohammad Shabani The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices The Scientific World Journal |
| title | The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices |
| title_full | The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices |
| title_fullStr | The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices |
| title_full_unstemmed | The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices |
| title_short | The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices |
| title_sort | effect of angipars on diabetic neuropathy in stz induced diabetic male rats a study on behavioral electrophysiological sciatic histological and ultrastructural indices |
| url | http://dx.doi.org/10.1155/2014/721547 |
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