Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic‐Comorbidities Related Signatures in Craniopharyngioma

Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic‐Comorbidities Related Signatures in Craniopharyngioma

Abstract Craniopharyngioma (CP) is an intracranial tumor with high mortality and morbidity. Though biologically benign, CP will damage the hypothalamus, inducing comorbidities such as obesity, metabolic syndrome, and cognitive impairments. The roles of gut microbiome and serum metabolome in CP‐assoc...

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Main Authors: Ben Lin, Zhen Ye, Zhan Cao, Zhao Ye, Yifei Yu, Weiliang Jiang, Sichen Guo, Vladimir Melnikov, Peng Zhou, Chenxing Ji, Chengzhang Shi, Zerui Wu, Zhengyuan Chen, Yihua Xu, Qilin Zhang, Zengyi Ma, Nidan Qiao, Long Chen, Xuefei Shou, Xiaoyun Cao, Xiang Zhou, Li Zhang, Min He, Yongfei Wang, Hongying Ye, Yiming Li, Zhaoyun Zhang, Meng Wang, Renyuan Gao, Yichao Zhang
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
craniopharyngiomas
gut microbiota
hypothalamus‐pituitary axis
serum metabolome
Online Access:https://doi.org/10.1002/advs.202400684
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