Efficacy of deep brain stimulation in locomotor function recovery post-spinal cord injury: a systematic review and meta-analysis
Abstract Background Spinal cord injury (SCI) is a debilitating condition affecting the young demographic and represents a significant clinical challenge due to the complexities associated with rehabilitating locomotor function. Aim This systematic review and meta-analysis aimed to investigate the im...
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| Format: | Article |
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SpringerOpen
2025-07-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41983-025-00996-z |
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| author | Parisa Javadnia Amir Reza Bahadori Sara Ahmadi Iman Amanizadeh Mohammad Amin Fathollahi Afshan Davari Abbas Tafakhori Alireza Soltani Khaboushan Sajad Shafiee Sara Ranji |
| author_facet | Parisa Javadnia Amir Reza Bahadori Sara Ahmadi Iman Amanizadeh Mohammad Amin Fathollahi Afshan Davari Abbas Tafakhori Alireza Soltani Khaboushan Sajad Shafiee Sara Ranji |
| author_sort | Parisa Javadnia |
| collection | DOAJ |
| description | Abstract Background Spinal cord injury (SCI) is a debilitating condition affecting the young demographic and represents a significant clinical challenge due to the complexities associated with rehabilitating locomotor function. Aim This systematic review and meta-analysis aimed to investigate the impact of deep brain stimulation (DBS) on SCI. Methods This systematic review and meta-analysis were executed following PRISMA guidelines. Data were thoroughly examined across several databases, including PubMed, Scopus, Embase, Web of Science, and the Cochrane Library, with a cutoff date of 15 December 2024. Statistical evaluations were performed using Comprehensive Meta-Analysis software version 3.0. Results The review incorporated nine studies including both animal and human participants with SCI that underwent DBS, four of which were subjected to meta-analysis. Targeted DBS sites included the mesencephalic locomotor region (MLR), nucleus raphe magnus (NRM), periaqueductal gray matter (PAG), and lateral hypothalamus. The meta-analysis comprised 154 rats; results indicated a significant enhancement in the BBB locomotion score post-DBS implantation (standardized mean difference (SMD) = − 2.028, 95% CI: − 3.144 to − 0.913, p < 0.001). However, a notable high degree of heterogeneity was observed (Q = 90.901, I 2 = 94.500, p < 0.001). There were no reported adverse events associated with the interventions. The quality assessments of the included studies revealed a low risk of bias. Conclusion The findings suggest that DBS, mainly targeting the MLR, demonstrates significant efficacy in motor rehabilitation in animal models. Consequently, it is advisable to consider further clinical trial studies to assess the safety and efficacy of this intervention in individuals with incomplete spinal cord injuries. |
| format | Article |
| id | doaj-art-8792ac5ccdab4e3aaa6da2c7291386b4 |
| institution | Kabale University |
| issn | 1687-8329 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj-art-8792ac5ccdab4e3aaa6da2c7291386b42025-08-20T03:37:28ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292025-07-0161111710.1186/s41983-025-00996-zEfficacy of deep brain stimulation in locomotor function recovery post-spinal cord injury: a systematic review and meta-analysisParisa Javadnia0Amir Reza Bahadori1Sara Ahmadi2Iman Amanizadeh3Mohammad Amin Fathollahi4Afshan Davari5Abbas Tafakhori6Alireza Soltani Khaboushan7Sajad Shafiee8Sara Ranji9Iran University of Medical SciencesShiraz University of Medical SciencesTehran University of Medical SciencesTehran University of Medical SciencesTehran University of Medical SciencesIranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesIranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesTehran University of Medical SciencesMazandaran University of Medical SciencesIranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesAbstract Background Spinal cord injury (SCI) is a debilitating condition affecting the young demographic and represents a significant clinical challenge due to the complexities associated with rehabilitating locomotor function. Aim This systematic review and meta-analysis aimed to investigate the impact of deep brain stimulation (DBS) on SCI. Methods This systematic review and meta-analysis were executed following PRISMA guidelines. Data were thoroughly examined across several databases, including PubMed, Scopus, Embase, Web of Science, and the Cochrane Library, with a cutoff date of 15 December 2024. Statistical evaluations were performed using Comprehensive Meta-Analysis software version 3.0. Results The review incorporated nine studies including both animal and human participants with SCI that underwent DBS, four of which were subjected to meta-analysis. Targeted DBS sites included the mesencephalic locomotor region (MLR), nucleus raphe magnus (NRM), periaqueductal gray matter (PAG), and lateral hypothalamus. The meta-analysis comprised 154 rats; results indicated a significant enhancement in the BBB locomotion score post-DBS implantation (standardized mean difference (SMD) = − 2.028, 95% CI: − 3.144 to − 0.913, p < 0.001). However, a notable high degree of heterogeneity was observed (Q = 90.901, I 2 = 94.500, p < 0.001). There were no reported adverse events associated with the interventions. The quality assessments of the included studies revealed a low risk of bias. Conclusion The findings suggest that DBS, mainly targeting the MLR, demonstrates significant efficacy in motor rehabilitation in animal models. Consequently, it is advisable to consider further clinical trial studies to assess the safety and efficacy of this intervention in individuals with incomplete spinal cord injuries.https://doi.org/10.1186/s41983-025-00996-zSpinal cord injuriesDeep brain stimulationMesencephalic locomotor regionNucleus raphe magnusPeriaqueductal grayLateral hypothalamus |
| spellingShingle | Parisa Javadnia Amir Reza Bahadori Sara Ahmadi Iman Amanizadeh Mohammad Amin Fathollahi Afshan Davari Abbas Tafakhori Alireza Soltani Khaboushan Sajad Shafiee Sara Ranji Efficacy of deep brain stimulation in locomotor function recovery post-spinal cord injury: a systematic review and meta-analysis The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Spinal cord injuries Deep brain stimulation Mesencephalic locomotor region Nucleus raphe magnus Periaqueductal gray Lateral hypothalamus |
| title | Efficacy of deep brain stimulation in locomotor function recovery post-spinal cord injury: a systematic review and meta-analysis |
| title_full | Efficacy of deep brain stimulation in locomotor function recovery post-spinal cord injury: a systematic review and meta-analysis |
| title_fullStr | Efficacy of deep brain stimulation in locomotor function recovery post-spinal cord injury: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy of deep brain stimulation in locomotor function recovery post-spinal cord injury: a systematic review and meta-analysis |
| title_short | Efficacy of deep brain stimulation in locomotor function recovery post-spinal cord injury: a systematic review and meta-analysis |
| title_sort | efficacy of deep brain stimulation in locomotor function recovery post spinal cord injury a systematic review and meta analysis |
| topic | Spinal cord injuries Deep brain stimulation Mesencephalic locomotor region Nucleus raphe magnus Periaqueductal gray Lateral hypothalamus |
| url | https://doi.org/10.1186/s41983-025-00996-z |
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