Economic burden of pertussis in children: A single-center analysis in Hangzhou, China
The “reemergence of pertussis” has elicited international concerns, occurring paradoxically amidst the expansion of immunization programs. This study was aimed to evaluate quantitatively the economic burden and identify the determinants that influence the cost associated with treating pertussis in C...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2343199 |
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| author | Yan Liu Yingying Yang Jinsi Zhou Xuechao Zhang Lintao Gu Yuyang Xu Zhaojun Lu Qixin Xie Xiaoping Zhang Chunzhen Hua |
| author_facet | Yan Liu Yingying Yang Jinsi Zhou Xuechao Zhang Lintao Gu Yuyang Xu Zhaojun Lu Qixin Xie Xiaoping Zhang Chunzhen Hua |
| author_sort | Yan Liu |
| collection | DOAJ |
| description | The “reemergence of pertussis” has elicited international concerns, occurring paradoxically amidst the expansion of immunization programs. This study was aimed to evaluate quantitatively the economic burden and identify the determinants that influence the cost associated with treating pertussis in Chinese children. We evaluated the economic burden by Chinese children diagnosed with pertussis at the Children’s Hospital, Zhejiang University School of Medicine in 2022. Direct medical expenses and the utilization of medical resources attributed to pertussis were calculated. A generalized linear regression model was applied to analyze the determinants that were associated with the direct medical expenses among patients. Among the 1110 pertussis patients included in the study, 1060 were outpatients and 50 were inpatients. The average direct medical cost was ¥1878.70(i.e. $279.33). Living in urban areas (OR:1.27, p = .04), complications (OR:1.40, p < .001), hospitalization (OR:10.04, p < .001), and ≥ 3 medical visits (OR:3.71, p < .001) were associated with increased direct medical expenses. Having received four doses of the pertussis vaccine was associated with reduced direct medical expenses (OR:0.81, p = .04). This study underscores a substantial economic burden of pertussis in Hangzhou, with pronounced implications for patients residing in urban areas, experiencing complications, requiring hospitalization, having multiple medical consultations, or lacking comprehensive pertussis vaccination. |
| format | Article |
| id | doaj-art-8790dde1787b4237a019f08073901b75 |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-8790dde1787b4237a019f08073901b752025-08-20T03:12:40ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2343199Economic burden of pertussis in children: A single-center analysis in Hangzhou, ChinaYan Liu0Yingying Yang1Jinsi Zhou2Xuechao Zhang3Lintao Gu4Yuyang Xu5Zhaojun Lu6Qixin Xie7Xiaoping Zhang8Chunzhen Hua9Department of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Infectious Diseases, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Infectious Diseases, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaThe “reemergence of pertussis” has elicited international concerns, occurring paradoxically amidst the expansion of immunization programs. This study was aimed to evaluate quantitatively the economic burden and identify the determinants that influence the cost associated with treating pertussis in Chinese children. We evaluated the economic burden by Chinese children diagnosed with pertussis at the Children’s Hospital, Zhejiang University School of Medicine in 2022. Direct medical expenses and the utilization of medical resources attributed to pertussis were calculated. A generalized linear regression model was applied to analyze the determinants that were associated with the direct medical expenses among patients. Among the 1110 pertussis patients included in the study, 1060 were outpatients and 50 were inpatients. The average direct medical cost was ¥1878.70(i.e. $279.33). Living in urban areas (OR:1.27, p = .04), complications (OR:1.40, p < .001), hospitalization (OR:10.04, p < .001), and ≥ 3 medical visits (OR:3.71, p < .001) were associated with increased direct medical expenses. Having received four doses of the pertussis vaccine was associated with reduced direct medical expenses (OR:0.81, p = .04). This study underscores a substantial economic burden of pertussis in Hangzhou, with pronounced implications for patients residing in urban areas, experiencing complications, requiring hospitalization, having multiple medical consultations, or lacking comprehensive pertussis vaccination.https://www.tandfonline.com/doi/10.1080/21645515.2024.2343199pertussispertussis vaccinationfactorsdirect medical costs |
| spellingShingle | Yan Liu Yingying Yang Jinsi Zhou Xuechao Zhang Lintao Gu Yuyang Xu Zhaojun Lu Qixin Xie Xiaoping Zhang Chunzhen Hua Economic burden of pertussis in children: A single-center analysis in Hangzhou, China Human Vaccines & Immunotherapeutics pertussis pertussis vaccination factors direct medical costs |
| title | Economic burden of pertussis in children: A single-center analysis in Hangzhou, China |
| title_full | Economic burden of pertussis in children: A single-center analysis in Hangzhou, China |
| title_fullStr | Economic burden of pertussis in children: A single-center analysis in Hangzhou, China |
| title_full_unstemmed | Economic burden of pertussis in children: A single-center analysis in Hangzhou, China |
| title_short | Economic burden of pertussis in children: A single-center analysis in Hangzhou, China |
| title_sort | economic burden of pertussis in children a single center analysis in hangzhou china |
| topic | pertussis pertussis vaccination factors direct medical costs |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2343199 |
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