Long-Term Effects of Placental Growth on Overweight and Body Composition
Obesity is programmed in utero and small babies generally have small placentas. In some circumstances, an undernourished fetus can expand its placental surface to extract more nutrients. We hypothesize that this results in an imbalanced nutrient supply to the fetus leading to obesity. To determine...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/324185 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850213818218577920 |
|---|---|
| author | Johan G. Eriksson Jill Gelow Kent L. Thornburg Clive Osmond Markku Laakso Matti Uusitupa Virpi Lindi Eero Kajantie David J. P. Barker |
| author_facet | Johan G. Eriksson Jill Gelow Kent L. Thornburg Clive Osmond Markku Laakso Matti Uusitupa Virpi Lindi Eero Kajantie David J. P. Barker |
| author_sort | Johan G. Eriksson |
| collection | DOAJ |
| description | Obesity is programmed in utero and small babies generally have small placentas. In some circumstances, an undernourished fetus can expand its placental surface to extract more nutrients. We hypothesize that this results in an imbalanced nutrient supply to the fetus leading to obesity. To determine whether placental size determines overweight and body composition, we studied 2003 subjects in adult life. Associations between placental surface area and indices of overweight were restricted to people who carried the Pro12Pro genotype of the PPARγ2 gene. For every 1 SD increase in placental surface area, the odds ratio for overweight was 1.37 (95% CI 1.10 to 1.71; P=0.005). Expansion of the placental surface in compensation for fetal undernutrition increases the risk of overweight and a higher body fat percentage in people carrying the Pro12Pro genotype. We suggest that similar underlying multifactorial mechanisms affect the development of obesity in general. |
| format | Article |
| id | doaj-art-878f32b7d7ed417dbf71ff90b2faae91 |
| institution | OA Journals |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-878f32b7d7ed417dbf71ff90b2faae912025-08-20T02:09:04ZengWileyInternational Journal of Pediatrics1687-97401687-97592012-01-01201210.1155/2012/324185324185Long-Term Effects of Placental Growth on Overweight and Body CompositionJohan G. Eriksson0Jill Gelow1Kent L. Thornburg2Clive Osmond3Markku Laakso4Matti Uusitupa5Virpi Lindi6Eero Kajantie7David J. P. Barker8Department of General Practice and Primary Health Care, University of Helsinki, PL 20, 00014 Helsinki, FinlandHeart Research Center, Oregon Health and Science University, Portland, OR 97201-3098, USAHeart Research Center, Oregon Health and Science University, Portland, OR 97201-3098, USAMRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UKDepartment of Internal Medicine, Kuopio University Hospital, 70211 Kuopio, FinlandDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, FinlandDepartment of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, FinlandDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, PL 30, 00271 Helsinki, FinlandHeart Research Center, Oregon Health and Science University, Portland, OR 97201-3098, USAObesity is programmed in utero and small babies generally have small placentas. In some circumstances, an undernourished fetus can expand its placental surface to extract more nutrients. We hypothesize that this results in an imbalanced nutrient supply to the fetus leading to obesity. To determine whether placental size determines overweight and body composition, we studied 2003 subjects in adult life. Associations between placental surface area and indices of overweight were restricted to people who carried the Pro12Pro genotype of the PPARγ2 gene. For every 1 SD increase in placental surface area, the odds ratio for overweight was 1.37 (95% CI 1.10 to 1.71; P=0.005). Expansion of the placental surface in compensation for fetal undernutrition increases the risk of overweight and a higher body fat percentage in people carrying the Pro12Pro genotype. We suggest that similar underlying multifactorial mechanisms affect the development of obesity in general.http://dx.doi.org/10.1155/2012/324185 |
| spellingShingle | Johan G. Eriksson Jill Gelow Kent L. Thornburg Clive Osmond Markku Laakso Matti Uusitupa Virpi Lindi Eero Kajantie David J. P. Barker Long-Term Effects of Placental Growth on Overweight and Body Composition International Journal of Pediatrics |
| title | Long-Term Effects of Placental Growth on Overweight and Body Composition |
| title_full | Long-Term Effects of Placental Growth on Overweight and Body Composition |
| title_fullStr | Long-Term Effects of Placental Growth on Overweight and Body Composition |
| title_full_unstemmed | Long-Term Effects of Placental Growth on Overweight and Body Composition |
| title_short | Long-Term Effects of Placental Growth on Overweight and Body Composition |
| title_sort | long term effects of placental growth on overweight and body composition |
| url | http://dx.doi.org/10.1155/2012/324185 |
| work_keys_str_mv | AT johangeriksson longtermeffectsofplacentalgrowthonoverweightandbodycomposition AT jillgelow longtermeffectsofplacentalgrowthonoverweightandbodycomposition AT kentlthornburg longtermeffectsofplacentalgrowthonoverweightandbodycomposition AT cliveosmond longtermeffectsofplacentalgrowthonoverweightandbodycomposition AT markkulaakso longtermeffectsofplacentalgrowthonoverweightandbodycomposition AT mattiuusitupa longtermeffectsofplacentalgrowthonoverweightandbodycomposition AT virpilindi longtermeffectsofplacentalgrowthonoverweightandbodycomposition AT eerokajantie longtermeffectsofplacentalgrowthonoverweightandbodycomposition AT davidjpbarker longtermeffectsofplacentalgrowthonoverweightandbodycomposition |