Septins: New Microtubule Interacting Partners
Originally characterized as regulators of cytokinesis, septins were later implicated in other cellular processes. Recent studies show that septins have a broader role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape. Many members of the septin famil...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2008.87 |
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| _version_ | 1849401676825362432 |
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| author | Rosalind Silverman-Gavrila Lorelei Silverman-Gavrila |
| author_facet | Rosalind Silverman-Gavrila Lorelei Silverman-Gavrila |
| author_sort | Rosalind Silverman-Gavrila |
| collection | DOAJ |
| description | Originally characterized as regulators of cytokinesis, septins were later implicated in other cellular processes. Recent studies show that septins have a broader role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape. Many members of the septin family have been shown to colocalize or interact with the microtubule cytoskeleton, suggesting that these might be general properties of septins. Septins could play an important role in regulating microtubule dynamics by interacting with microtubule-associated proteins (MAPs) that modulate microtubule stability. Being able to associate with both microtubules and actin, septins can play an important role as adaptors between the two cytoskeletons and as regulators of processes in which both actin and microtubules are involved. As septins are associated with various neurodegenerative diseases and cancer, a better understanding of the biology of septins and their interactions with microtubules is important in order to develop possible therapeutic strategies for these diseases. |
| format | Article |
| id | doaj-art-878ec5ab4dc9430c8a475cbd7bbc153f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-878ec5ab4dc9430c8a475cbd7bbc153f2025-08-20T03:37:43ZengWileyThe Scientific World Journal1537-744X2008-01-01861162010.1100/tsw.2008.87Septins: New Microtubule Interacting PartnersRosalind Silverman-Gavrila0Lorelei Silverman-Gavrila1University of Toronto, Faculty of Medicine andToronto General Hospital, Division of Cellular and Molecular Biology, Max Bell Research Centre, Toronto, Ontario, CanadaUniversity of Toronto, Faculty of Medicine, Department of Physiology, Toronto, Ontario, CanadaOriginally characterized as regulators of cytokinesis, septins were later implicated in other cellular processes. Recent studies show that septins have a broader role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape. Many members of the septin family have been shown to colocalize or interact with the microtubule cytoskeleton, suggesting that these might be general properties of septins. Septins could play an important role in regulating microtubule dynamics by interacting with microtubule-associated proteins (MAPs) that modulate microtubule stability. Being able to associate with both microtubules and actin, septins can play an important role as adaptors between the two cytoskeletons and as regulators of processes in which both actin and microtubules are involved. As septins are associated with various neurodegenerative diseases and cancer, a better understanding of the biology of septins and their interactions with microtubules is important in order to develop possible therapeutic strategies for these diseases.http://dx.doi.org/10.1100/tsw.2008.87 |
| spellingShingle | Rosalind Silverman-Gavrila Lorelei Silverman-Gavrila Septins: New Microtubule Interacting Partners The Scientific World Journal |
| title | Septins: New Microtubule Interacting Partners |
| title_full | Septins: New Microtubule Interacting Partners |
| title_fullStr | Septins: New Microtubule Interacting Partners |
| title_full_unstemmed | Septins: New Microtubule Interacting Partners |
| title_short | Septins: New Microtubule Interacting Partners |
| title_sort | septins new microtubule interacting partners |
| url | http://dx.doi.org/10.1100/tsw.2008.87 |
| work_keys_str_mv | AT rosalindsilvermangavrila septinsnewmicrotubuleinteractingpartners AT loreleisilvermangavrila septinsnewmicrotubuleinteractingpartners |