Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity
Background. Overdose with calcium-channel blockers (CCBs) still maintain their importance with a high lethality rate after exposure. We report the intravenous lipid emulsion therapy (ILE) therapy in our CCB overdose patients. Methods. We retrospectively analyzed the records of 6 patients with CC...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2024-02-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/5111 |
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| author | Sinan Yavuz Ali Avcı Rabia Gündoğan Serin Mustafa Mesut Kaya Dilfuza Ağalıoğlu |
| author_facet | Sinan Yavuz Ali Avcı Rabia Gündoğan Serin Mustafa Mesut Kaya Dilfuza Ağalıoğlu |
| author_sort | Sinan Yavuz |
| collection | DOAJ |
| description |
Background. Overdose with calcium-channel blockers (CCBs) still maintain their importance with a high lethality rate after exposure. We report the intravenous lipid emulsion therapy (ILE) therapy in our CCB overdose patients.
Methods. We retrospectively analyzed the records of 6 patients with CCB intoxication from Batman Training and Research Hospital PICU between March 2021 and September 2022. Patients aged 0-18 years who received ILE treatment for CCB poisoning were included.
Results. All six patients ingested CCB with the intention of committing suicide and were followed up in the pediatric intensive care unit (PICU). All patients received ILE therapy due to hemodynamic instability despite intravenous fluid boluses, calcium, glucagon, insulin-dextrose, and vasoactive agents. Vasoactive-Inotropic Score (VIS) decreased after ILE treatment. All patients were transferred from the PICU after recovery.
Conclusions. ILE therapy should be kept in mind as a salvage therapy in hemodynamically unstable CCB poisoning cases that do not respond to initial and advanced options.
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| format | Article |
| id | doaj-art-8789eb0dfe21460abd6ffabb3b0931f2 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-8789eb0dfe21460abd6ffabb3b0931f22025-08-20T02:00:47ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212024-02-0166110.24953/turkjped.2023.543Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicitySinan Yavuz0https://orcid.org/0000-0001-6159-8710Ali Avcı1https://orcid.org/0000-0002-3123-1691Rabia Gündoğan Serin2https://orcid.org/0000-0001-7465-171XMustafa Mesut Kaya3https://orcid.org/0000-0002-8111-0468Dilfuza Ağalıoğlu4https://orcid.org/0000-0002-8510-310XDepartment of Pediatric Intensive Care Unit, Batman Education and Research Hospital, Batman, TürkiyeDepartment of Pediatric Intensive Care Unit, Batman Education and Research Hospital, Batman, TürkiyeDepartment of Pediatric Intensive Care Unit, Batman Education and Research Hospital, Batman, TürkiyeDepartment of Pediatric Intensive Care Unit, Batman Education and Research Hospital, Batman, TürkiyeDepartment of Pediatric Intensive Care Unit, Batman Education and Research Hospital, Batman, Türkiye Background. Overdose with calcium-channel blockers (CCBs) still maintain their importance with a high lethality rate after exposure. We report the intravenous lipid emulsion therapy (ILE) therapy in our CCB overdose patients. Methods. We retrospectively analyzed the records of 6 patients with CCB intoxication from Batman Training and Research Hospital PICU between March 2021 and September 2022. Patients aged 0-18 years who received ILE treatment for CCB poisoning were included. Results. All six patients ingested CCB with the intention of committing suicide and were followed up in the pediatric intensive care unit (PICU). All patients received ILE therapy due to hemodynamic instability despite intravenous fluid boluses, calcium, glucagon, insulin-dextrose, and vasoactive agents. Vasoactive-Inotropic Score (VIS) decreased after ILE treatment. All patients were transferred from the PICU after recovery. Conclusions. ILE therapy should be kept in mind as a salvage therapy in hemodynamically unstable CCB poisoning cases that do not respond to initial and advanced options. https://turkjpediatr.org/article/view/5111calcium channel blockerslipid emulsionpediatricsintoxication |
| spellingShingle | Sinan Yavuz Ali Avcı Rabia Gündoğan Serin Mustafa Mesut Kaya Dilfuza Ağalıoğlu Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity The Turkish Journal of Pediatrics calcium channel blockers lipid emulsion pediatrics intoxication |
| title | Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity |
| title_full | Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity |
| title_fullStr | Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity |
| title_full_unstemmed | Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity |
| title_short | Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity |
| title_sort | effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity |
| topic | calcium channel blockers lipid emulsion pediatrics intoxication |
| url | https://turkjpediatr.org/article/view/5111 |
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