Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS
Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray d...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/3591908 |
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| author | Carlos Cardoso-Palacios Ingela Lanekoff |
| author_facet | Carlos Cardoso-Palacios Ingela Lanekoff |
| author_sort | Carlos Cardoso-Palacios |
| collection | DOAJ |
| description | Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surface sampling technique which enables sampling of molecules directly from the surface of the tablets without any sample pretreatment. Both the active pharmaceutical ingredients (APIs) and some excipients were detected in all analyzed tablets. Principal component analysis was used to analyze mass spectral features from different tablets showing strong clustering between tablets with different APIs. The obtained results suggest nano-DESI MS as future tool for forensic analysis to discern APIs present in unknown tablet samples. |
| format | Article |
| id | doaj-art-8782ebbdf97c4965852ad7c6ea3323e7 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-8782ebbdf97c4965852ad7c6ea3323e72025-02-03T01:03:10ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732016-01-01201610.1155/2016/35919083591908Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MSCarlos Cardoso-Palacios0Ingela Lanekoff1Department of Chemistry-BMC, Uppsala University, Uppsala, SwedenDepartment of Chemistry-BMC, Uppsala University, Uppsala, SwedenCounterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surface sampling technique which enables sampling of molecules directly from the surface of the tablets without any sample pretreatment. Both the active pharmaceutical ingredients (APIs) and some excipients were detected in all analyzed tablets. Principal component analysis was used to analyze mass spectral features from different tablets showing strong clustering between tablets with different APIs. The obtained results suggest nano-DESI MS as future tool for forensic analysis to discern APIs present in unknown tablet samples.http://dx.doi.org/10.1155/2016/3591908 |
| spellingShingle | Carlos Cardoso-Palacios Ingela Lanekoff Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS Journal of Analytical Methods in Chemistry |
| title | Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS |
| title_full | Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS |
| title_fullStr | Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS |
| title_full_unstemmed | Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS |
| title_short | Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS |
| title_sort | direct analysis of pharmaceutical drugs using nano desi ms |
| url | http://dx.doi.org/10.1155/2016/3591908 |
| work_keys_str_mv | AT carloscardosopalacios directanalysisofpharmaceuticaldrugsusingnanodesims AT ingelalanekoff directanalysisofpharmaceuticaldrugsusingnanodesims |