Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications
Abstract Wound healing outcomes critically depend on precise regulation of oxidative and antimicrobial microenvironments. Traditional dressings have limited wound responsiveness, insufficient infection control, and limited treatment accuracy. In contrast, nanozymes, featuring enzyme-mimetic activiti...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Journal of Nanobiotechnology |
| Online Access: | https://doi.org/10.1186/s12951-025-03558-w |
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| _version_ | 1849389337282609152 |
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| author | Xiaoyang Liu Huihui Zhang Lianglong Chen Zesen Zheng Wenwen Li Chaoyang Huang Hai Zhou Yanqi Chen Ziwei Jiang Jiaqi Liang Qiuyi Yu Lei Yang |
| author_facet | Xiaoyang Liu Huihui Zhang Lianglong Chen Zesen Zheng Wenwen Li Chaoyang Huang Hai Zhou Yanqi Chen Ziwei Jiang Jiaqi Liang Qiuyi Yu Lei Yang |
| author_sort | Xiaoyang Liu |
| collection | DOAJ |
| description | Abstract Wound healing outcomes critically depend on precise regulation of oxidative and antimicrobial microenvironments. Traditional dressings have limited wound responsiveness, insufficient infection control, and limited treatment accuracy. In contrast, nanozymes, featuring enzyme-mimetic activities, tunable catalysis, and engineered sizes that balance catalytic site accessibility with tissue penetration, offer spatiotemporal control of reactive oxygen species (ROS) and pathogen elimination. This review systematically examines recent advances in stimuli-responsive nanozymes for wound management, focusing on their catalytic mechanisms and therapeutic specificity. These intelligent systems dynamically adapt catalytic behaviors (e.g., ROS scavenging, bacterial lysis) to physical stimuli (temperature, light, ultrasound) and physiological signals (pH, redox imbalance, ATP levels, microbial metabolites), leveraging size-dependent targeting mechanisms to ensure localized therapeutic effects while minimizing off-target damage. Current evidence demonstrates their multifunctional capacity to synergistically accelerate infection clearance, inflammation resolution, and angiogenesis. Future development should prioritize biosafety validation alongside size-effect standardization, stimulus specificity, and scalable manufacturing to advance personalized nanomedicine for refractory wounds. |
| format | Article |
| id | doaj-art-877fbc41fc3d4662b7bc970d301d7cb5 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-877fbc41fc3d4662b7bc970d301d7cb52025-08-20T03:41:59ZengBMCJournal of Nanobiotechnology1477-31552025-07-0123114110.1186/s12951-025-03558-wAdvanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applicationsXiaoyang Liu0Huihui Zhang1Lianglong Chen2Zesen Zheng3Wenwen Li4Chaoyang Huang5Hai Zhou6Yanqi Chen7Ziwei Jiang8Jiaqi Liang9Qiuyi Yu10Lei Yang11Department of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityDepartment of Burns, Nanfang Hospital, Southern Medical UniversityAbstract Wound healing outcomes critically depend on precise regulation of oxidative and antimicrobial microenvironments. Traditional dressings have limited wound responsiveness, insufficient infection control, and limited treatment accuracy. In contrast, nanozymes, featuring enzyme-mimetic activities, tunable catalysis, and engineered sizes that balance catalytic site accessibility with tissue penetration, offer spatiotemporal control of reactive oxygen species (ROS) and pathogen elimination. This review systematically examines recent advances in stimuli-responsive nanozymes for wound management, focusing on their catalytic mechanisms and therapeutic specificity. These intelligent systems dynamically adapt catalytic behaviors (e.g., ROS scavenging, bacterial lysis) to physical stimuli (temperature, light, ultrasound) and physiological signals (pH, redox imbalance, ATP levels, microbial metabolites), leveraging size-dependent targeting mechanisms to ensure localized therapeutic effects while minimizing off-target damage. Current evidence demonstrates their multifunctional capacity to synergistically accelerate infection clearance, inflammation resolution, and angiogenesis. Future development should prioritize biosafety validation alongside size-effect standardization, stimulus specificity, and scalable manufacturing to advance personalized nanomedicine for refractory wounds.https://doi.org/10.1186/s12951-025-03558-w |
| spellingShingle | Xiaoyang Liu Huihui Zhang Lianglong Chen Zesen Zheng Wenwen Li Chaoyang Huang Hai Zhou Yanqi Chen Ziwei Jiang Jiaqi Liang Qiuyi Yu Lei Yang Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications Journal of Nanobiotechnology |
| title | Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications |
| title_full | Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications |
| title_fullStr | Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications |
| title_full_unstemmed | Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications |
| title_short | Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications |
| title_sort | advanced wound healing with stimuli responsive nanozymes mechanisms design and applications |
| url | https://doi.org/10.1186/s12951-025-03558-w |
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