Combined Blockade of Lipid Uptake and Synthesis by CD36 Inhibitor and SCD1 siRNA Is Beneficial for the Treatment of Refractory Prostate Cancer

Combined Blockade of Lipid Uptake and Synthesis by CD36 Inhibitor and SCD1 siRNA Is Beneficial for the Treatment of Refractory Prostate Cancer

Abstract Drug resistance is an important factor for prostate cancer (PCa) to progress into refractory PCa, and abnormal lipid metabolism usually occurs in refractory PCa, which presents great challenges for PCa therapy. Here, a cluster of differentiation 36 (CD36) inhibitor sulfosuccinimidyl oleate...

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Bibliographic Details
Main Authors: Jiyuan Chen, Xiaoyan Yu, Gang Yang, Xueying Chen, Chunai Gong, Lu Han, Yujie Wang, Rong Wang, Lei Wang, Yongfang Yuan
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
CD36
drug resistance
lipid metabolism
refractory prostate cancer
SCD1
Online Access:https://doi.org/10.1002/advs.202412244
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