Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study
Purpose The LipidCardio Study was established for in-depth analyses of cardiovascular risk factors, providing well-defined cardiovascular and metabolic phenotypes. In particular, the role of lipoproteins in the pathobiological process and treatment of cardiovascular disease (CVD) will be a main focu...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2019-09-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/9/e030097.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850129595220623360 |
|---|---|
| author | Ulf Landmesser David M Leistner Maximilian König Samita Joshi David Sinning Elisabeth Steinhagen-Thiessen Ilja Demuth |
| author_facet | Ulf Landmesser David M Leistner Maximilian König Samita Joshi David Sinning Elisabeth Steinhagen-Thiessen Ilja Demuth |
| author_sort | Ulf Landmesser |
| collection | DOAJ |
| description | Purpose The LipidCardio Study was established for in-depth analyses of cardiovascular risk factors, providing well-defined cardiovascular and metabolic phenotypes. In particular, the role of lipoproteins in the pathobiological process and treatment of cardiovascular disease (CVD) will be a main focus.Participants 1005 individuals aged 21 years and older undergoing cardiac catheterisation during 17 months at a tertiary academic cardiology centre were enrolled (troponin-positive acute coronary syndrome was exclusion criterion). The baseline data not only contain detailed phenotyping, broad biochemical parameters, genetic data, but also standardised personal and family history, a screening test for cognitive impairment, pulse wave analysis and measurements of hand grip strength, among others. Blood samples were stored in a biobank for future analyses.Findings to date The mean age of the participants at enrolment was 70.9±11.1 years (70% male). Coronary angiography provided evidence of obstructive coronary artery disease (CAD) in 69.9% of participants. Those with evidence of CAD were significantly more likely to be male, inactive, diabetic and with a family history of CVD than participants without CAD.About 20% of patients had lipoprotein(a) (Lp(a)) concentrations above 106.9 nmol/L (fifth quintile). These patients had significantly increased odds of obstructive CAD compared with participants in quintiles 1–4 (crude OR 1.70, 95% CI 1.17 to 2.48, p=0.005). There was reasonable evidence that with increasing severity of CAD the odds of having elevated Lp(a) increased. We were able to replicate the established strong association between specified single nucleotide polymorphisms (SNPs) in the LPA gene (rs10455872, rs3798220 and rs186696265) and the APOE gene (rs7412), and the concentration of Lp(a), validating our phenotype database and biobank.Future plans Mortality information will be obtained in 2 year intervals. Follow-up phone interviews will be conducted at 3 and 6 years after enrolment. We seek to cooperate with other researchers, for example, by sharing data and biobank samples. |
| format | Article |
| id | doaj-art-877b4d09660241fe87285ab17bc21358 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-877b4d09660241fe87285ab17bc213582025-08-20T02:32:56ZengBMJ Publishing GroupBMJ Open2044-60552019-09-019910.1136/bmjopen-2019-030097Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio studyUlf Landmesser0David M Leistner1Maximilian König2Samita Joshi3David Sinning4Elisabeth Steinhagen-Thiessen5Ilja Demuth6German Center for Cardiovascular Research (DZHK), partner site Berlin, Berlin, GermanyCardiology and Vascular Medicine Department, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany1 Medical Department, Division of Nephrology and Internal Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany2 Lipid Clinic at the Interdisciplinary Metabolism Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany3 Department of Cardiology, Campus Benjamin Franklin (CBF), Charité - Universitätsmedizin Berlin, Berlin, Germanyprofessor of geriatricsDepartment of Endocrinology and Metabolic Diseases (including Division of Lipid Metabolism), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, GermanyPurpose The LipidCardio Study was established for in-depth analyses of cardiovascular risk factors, providing well-defined cardiovascular and metabolic phenotypes. In particular, the role of lipoproteins in the pathobiological process and treatment of cardiovascular disease (CVD) will be a main focus.Participants 1005 individuals aged 21 years and older undergoing cardiac catheterisation during 17 months at a tertiary academic cardiology centre were enrolled (troponin-positive acute coronary syndrome was exclusion criterion). The baseline data not only contain detailed phenotyping, broad biochemical parameters, genetic data, but also standardised personal and family history, a screening test for cognitive impairment, pulse wave analysis and measurements of hand grip strength, among others. Blood samples were stored in a biobank for future analyses.Findings to date The mean age of the participants at enrolment was 70.9±11.1 years (70% male). Coronary angiography provided evidence of obstructive coronary artery disease (CAD) in 69.9% of participants. Those with evidence of CAD were significantly more likely to be male, inactive, diabetic and with a family history of CVD than participants without CAD.About 20% of patients had lipoprotein(a) (Lp(a)) concentrations above 106.9 nmol/L (fifth quintile). These patients had significantly increased odds of obstructive CAD compared with participants in quintiles 1–4 (crude OR 1.70, 95% CI 1.17 to 2.48, p=0.005). There was reasonable evidence that with increasing severity of CAD the odds of having elevated Lp(a) increased. We were able to replicate the established strong association between specified single nucleotide polymorphisms (SNPs) in the LPA gene (rs10455872, rs3798220 and rs186696265) and the APOE gene (rs7412), and the concentration of Lp(a), validating our phenotype database and biobank.Future plans Mortality information will be obtained in 2 year intervals. Follow-up phone interviews will be conducted at 3 and 6 years after enrolment. We seek to cooperate with other researchers, for example, by sharing data and biobank samples.https://bmjopen.bmj.com/content/9/9/e030097.full |
| spellingShingle | Ulf Landmesser David M Leistner Maximilian König Samita Joshi David Sinning Elisabeth Steinhagen-Thiessen Ilja Demuth Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study BMJ Open |
| title | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
| title_full | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
| title_fullStr | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
| title_full_unstemmed | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
| title_short | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
| title_sort | cohort profile role of lipoproteins in cardiovascular disease the lipidcardio study |
| url | https://bmjopen.bmj.com/content/9/9/e030097.full |
| work_keys_str_mv | AT ulflandmesser cohortprofileroleoflipoproteinsincardiovasculardiseasethelipidcardiostudy AT davidmleistner cohortprofileroleoflipoproteinsincardiovasculardiseasethelipidcardiostudy AT maximiliankonig cohortprofileroleoflipoproteinsincardiovasculardiseasethelipidcardiostudy AT samitajoshi cohortprofileroleoflipoproteinsincardiovasculardiseasethelipidcardiostudy AT davidsinning cohortprofileroleoflipoproteinsincardiovasculardiseasethelipidcardiostudy AT elisabethsteinhagenthiessen cohortprofileroleoflipoproteinsincardiovasculardiseasethelipidcardiostudy AT iljademuth cohortprofileroleoflipoproteinsincardiovasculardiseasethelipidcardiostudy |