Fe-doped MOF nanoparticles: the LIFR and BMP4 dual-signaling pathways activated regulator for in vitro expansion of mouse embryonic stem cells

In the cultivation of mouse embryonic stem cells (mESCs), leukemia inhibitory factor (LIF) and mitotically inactive mouse embryonic fibroblasts (MEFs) are usually used to maintain the self-renewal and pluripotency of mESCs. However, the high cost of LIF and the immunogenicity of MEFs limit their cli...

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Bibliographic Details
Main Authors: Youyuan Li, Hong Wang, Zhilei Li, Huichao Wang, Yi Gao, Chaoran Wu, Bangguo Wei, Zhanyun Guo, Xijin Wang, Guoxin Jing, Shilong Wang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
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Online Access:http://www.sciencedirect.com/science/article/pii/S259000642500612X
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