Management and Outcome in 32 Neonates with Thrombotic Events
Objective. To determine the incidence, management, complications, and outcome in neonates with thrombotic events. Study Design. We performed a retrospective study of all neonates with thrombotic events admitted to our neonatal intensive care unit from January 2004 to July 2010. Results. Thrombotic e...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2011/217564 |
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| author | H. A. van Elteren H. S. Veldt A. B. te Pas A. A. W. Roest F. J. Smiers W. J. Kollen A. Sramek F. J. Walther E. Lopriore |
| author_facet | H. A. van Elteren H. S. Veldt A. B. te Pas A. A. W. Roest F. J. Smiers W. J. Kollen A. Sramek F. J. Walther E. Lopriore |
| author_sort | H. A. van Elteren |
| collection | DOAJ |
| description | Objective. To determine the incidence, management, complications, and outcome in neonates with thrombotic events. Study Design. We performed a retrospective study of all neonates with thrombotic events admitted to our neonatal intensive care unit from January 2004 to July 2010. Results. Thrombotic events were identified in 32 of 4734 neonates (0.7%). Seven neonates were managed expectantly and 25 neonates received anticoagulant treatment. Complete resolution of the clot within 3 months of age was found in 68% (17/25) of the treated and in 86% (6/7) of the nontreated neonates. Major complications due to anticoagulant therapy occurred in 3/25 cases (12%) and included severe hemorrhage () and abscess at the injection site (). Conclusion. Complete or partial clot resolution in neonatal thrombosis occurred in both the treated group and nontreated group. Randomized controlled trials are warranted to determine the optimal management in neonatal thrombosis. |
| format | Article |
| id | doaj-art-87602191dadd4f338afd2bb4754baecb |
| institution | OA Journals |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-87602191dadd4f338afd2bb4754baecb2025-08-20T02:09:04ZengWileyInternational Journal of Pediatrics1687-97401687-97592011-01-01201110.1155/2011/217564217564Management and Outcome in 32 Neonates with Thrombotic EventsH. A. van Elteren0H. S. Veldt1A. B. te Pas2A. A. W. Roest3F. J. Smiers4W. J. Kollen5A. Sramek6F. J. Walther7E. Lopriore8Division of Neonatology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDivision of Neonatology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDivision of Neonatology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDivision of Pediatric Cardiology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDivision of Immunology and Hemato-Oncology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDivision of Immunology and Hemato-Oncology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Radiology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDivision of Neonatology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDivision of Neonatology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The NetherlandsObjective. To determine the incidence, management, complications, and outcome in neonates with thrombotic events. Study Design. We performed a retrospective study of all neonates with thrombotic events admitted to our neonatal intensive care unit from January 2004 to July 2010. Results. Thrombotic events were identified in 32 of 4734 neonates (0.7%). Seven neonates were managed expectantly and 25 neonates received anticoagulant treatment. Complete resolution of the clot within 3 months of age was found in 68% (17/25) of the treated and in 86% (6/7) of the nontreated neonates. Major complications due to anticoagulant therapy occurred in 3/25 cases (12%) and included severe hemorrhage () and abscess at the injection site (). Conclusion. Complete or partial clot resolution in neonatal thrombosis occurred in both the treated group and nontreated group. Randomized controlled trials are warranted to determine the optimal management in neonatal thrombosis.http://dx.doi.org/10.1155/2011/217564 |
| spellingShingle | H. A. van Elteren H. S. Veldt A. B. te Pas A. A. W. Roest F. J. Smiers W. J. Kollen A. Sramek F. J. Walther E. Lopriore Management and Outcome in 32 Neonates with Thrombotic Events International Journal of Pediatrics |
| title | Management and Outcome in 32 Neonates with Thrombotic Events |
| title_full | Management and Outcome in 32 Neonates with Thrombotic Events |
| title_fullStr | Management and Outcome in 32 Neonates with Thrombotic Events |
| title_full_unstemmed | Management and Outcome in 32 Neonates with Thrombotic Events |
| title_short | Management and Outcome in 32 Neonates with Thrombotic Events |
| title_sort | management and outcome in 32 neonates with thrombotic events |
| url | http://dx.doi.org/10.1155/2011/217564 |
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