Long COVID symptoms 6 months after acute infection among people living with HIV and people not living with HIV

Long COVID symptoms 6 months after acute infection among people living with HIV and people not living with HIV

BackgroundChronic viral infections, such as Human Immunodeficiency Virus (HIV), and their reactivation are considered potential contributing factors to Long-Corona Virus Disease (LC). However, research on the long-term sequelae of Long-COVID in individuals with HIV is limited.MethodsWe conducted a c...

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Bibliographic Details
Main Authors: Qin Li, Yijie Ma, Peng He, Dongqiong Chen, Tingrui Zhang, Xiaoying Wang, Ying Xu, Peiming Li, Weibo Wen, Zefeng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
COVID-19
human immunodeficiency virus
Long-COVID
symptoms
cardiovascular biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1430214/full
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Summary:BackgroundChronic viral infections, such as Human Immunodeficiency Virus (HIV), and their reactivation are considered potential contributing factors to Long-Corona Virus Disease (LC). However, research on the long-term sequelae of Long-COVID in individuals with HIV is limited.MethodsWe conducted a case-control study involving a total of 84 participants categorized into two groups: people living with HIV (PLWH) and people not living with HIV (PNLWH) within the six-month post-infection LC population. Differences in sequelae symptoms, cardiovascular biomarkers (VCAM-1, ICAM-1, and ACE2), Severe Acute Respiratory Syndrome Coronavirus 2 neutralization antibodies (SARS-CoV-2 nAb) and cytokines (IFN-γ, IL-6, and IL-17) were analyzed between the two groups.ResultsAfter 6 months of infection, PLWH exhibited significantly higher serum levels of ACE2, VCAM-1, and ICAM-1 (P < 0.01, respectively) compared to PNLWH with COVID-19. Additionally, sequelae symptoms were more pronounced in PNLWH, and there were no differences in serum levels of IFN-γ, TNF-α, IL-6, and IL-17 between the two groups (P > 0.05, respectively).ConclusionPLWH had lower symptoms of LC and reduced frequency of symptoms, increased cardiovascular risk factors, and no differences in levels of inflammation or SARS-CoV-2 nAb levels when compared to PNLWH.
ISSN:1664-3224

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