Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with adverse reactions

Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with adverse reactions

Abstract Genomic variation drives phenotypic diversity, including individual differences in drug response. While coding polymorphisms linked to drug efficacy and adverse reactions are well characterized, the contribution of noncoding regulatory elements remains underexplored. Using CAGE (Cap Analysi...

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Bibliographic Details
Main Authors: Saki Gotoh-Saito, Ryoko Wada, Tomoe Nishimura, Hideya Kawaji
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59132-3
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