Cardiovascular syphilis: a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosis
Due to the low incidence of cardiovascular involvement in syphilis, there are currently no established consensus or guidelines for managing such cases. The patient, with no coronary artery disease risk factors, presented with chest pain and heart failure (HF). Emergency coronary angiography revealed...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1444974/full |
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| _version_ | 1849225265585061888 |
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| author | Ru Wang Li Zhang Binfeng Xia Min Kong Huihui Huang Xia Yin |
| author_facet | Ru Wang Li Zhang Binfeng Xia Min Kong Huihui Huang Xia Yin |
| author_sort | Ru Wang |
| collection | DOAJ |
| description | Due to the low incidence of cardiovascular involvement in syphilis, there are currently no established consensus or guidelines for managing such cases. The patient, with no coronary artery disease risk factors, presented with chest pain and heart failure (HF). Emergency coronary angiography revealed severe stenosis of the bilateral coronary ostia, with smooth intimal lining in the remaining coronary arteries. Echocardiography showed severe aortic regurgitation. Positive syphilis serology strongly suggested cardiovascular syphilis (CVS). The patient was transferred to cardiothoracic surgery for aortic valve replacement (AVR) and coronary artery bypass grafting (CABG), but died from acute HF despite resuscitation efforts. |
| format | Article |
| id | doaj-art-8754e0397ef04581b93c83ce1041b19d |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-8754e0397ef04581b93c83ce1041b19d2025-08-25T05:26:16ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-08-011210.3389/fcvm.2025.14449741444974Cardiovascular syphilis: a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosisRu WangLi ZhangBinfeng XiaMin KongHuihui HuangXia YinDue to the low incidence of cardiovascular involvement in syphilis, there are currently no established consensus or guidelines for managing such cases. The patient, with no coronary artery disease risk factors, presented with chest pain and heart failure (HF). Emergency coronary angiography revealed severe stenosis of the bilateral coronary ostia, with smooth intimal lining in the remaining coronary arteries. Echocardiography showed severe aortic regurgitation. Positive syphilis serology strongly suggested cardiovascular syphilis (CVS). The patient was transferred to cardiothoracic surgery for aortic valve replacement (AVR) and coronary artery bypass grafting (CABG), but died from acute HF despite resuscitation efforts.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1444974/fullcardiovascular syphilisbilateral coronary ostial stenosissevere aortic regurgitationheart failuredifferential diagnosis |
| spellingShingle | Ru Wang Li Zhang Binfeng Xia Min Kong Huihui Huang Xia Yin Cardiovascular syphilis: a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosis Frontiers in Cardiovascular Medicine cardiovascular syphilis bilateral coronary ostial stenosis severe aortic regurgitation heart failure differential diagnosis |
| title | Cardiovascular syphilis: a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosis |
| title_full | Cardiovascular syphilis: a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosis |
| title_fullStr | Cardiovascular syphilis: a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosis |
| title_full_unstemmed | Cardiovascular syphilis: a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosis |
| title_short | Cardiovascular syphilis: a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosis |
| title_sort | cardiovascular syphilis a rare case report and literature review of severe aortic regurgitation and bilateral coronary ostial stenosis |
| topic | cardiovascular syphilis bilateral coronary ostial stenosis severe aortic regurgitation heart failure differential diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1444974/full |
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