A pathway to sight

A pathway to sight

The breakdown of glutamine is an important metabolic pathway for the health and survival of rod photoreceptors within the retina.

Saved in:

Bibliographic Details
Main Author:	Katherine J Wert
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-05-01
Series:	eLife
Subjects:	photoreceptor glutaminase metabolism neurodegeneration vision
Online Access:	https://elifesciences.org/articles/107193
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival
by: Moloy T Goswami, et al.
Published: (2025-05-01)

Morphology and connectivity of retinal horizontal cells in two avian species
by: Anja Günther, et al.
Published: (2025-03-01)

Photoreceptor glucose metabolism determines normal retinal vascular growth
by: Zhongjie Fu, et al.
Published: (2017-11-01)

The metabolic shift of glutaminase 2 to glutaminase 1 promotes LGR5 + progenitor cell proliferation in liver cirrhosis
by: Defu Kong, et al.
Published: (2025-06-01)

Safety evaluation of the food enzyme glutaminase from the genetically modified Bacillus licheniformis strain NZYM‐JQ
by: EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), et al.
Published: (2024-04-01)

Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes
by: Sophia Grotz, et al.
Published: (2022-03-01)

Dyslipidemia in retinal metabolic disorders
by: Zhongjie Fu, et al.
Published: (2019-09-01)

Anticancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) capped silver and zinc oxide nanoparticles and its molecular characterization
by: Zabin K. Bagewadi, et al.
Published: (2025-03-01)

Immobilization of Vibrio cholerae S1 (NAG) L-Glutaminase on Different Supports
by: Shatha Salman Hassan
Published: (2010-06-01)

Effects of Sodium Hexametaphosphate on the Gel Properties and Structure of Glutaminase-Transaminase-Crosslinked Gelatin Gels
by: Junliang Chen, et al.
Published: (2025-06-01)

Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease
by: Asier Erramuzpe, et al.
Published: (2025-04-01)

The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes
by: S. V. Logvinov, et al.
Published: (2002-06-01)

Biochemical and biological evaluation of L-glutaminase from Aspergillus tamarii AUMC 10198 via solid-state fermentation
by: Ghada A. Youssef, et al.
Published: (2025-08-01)

Out of sight into vision : there is more to good vision than reading the fine print /
by: Cohen,Neville S.

Revolutionizing cancer treatment with Halomonas Aquamarina L-Glutaminase: insights from in vitro and computational studies
by: Sara Abdelsayed, et al.
Published: (2025-08-01)

Epigenetic Modifiers to Treat Retinal Degenerative Diseases
by: Evgenya Y. Popova, et al.
Published: (2025-06-01)

Endogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib
by: Menghui Wang, et al.
Published: (2025-04-01)

Editorial: Metabolic dysregulation in neurodegenerative diseases
by: Maria Jimenez-Gonzalez
Published: (2025-04-01)

Retrospective OCT Analysis of Sphingosine-1-Phosphate Modulator Fingolimod in Multiple Sclerosis
by: Wilson X. Wang, MD, MPhil, et al.
Published: (2025-11-01)

Photomorphogenic and Biochemical Effects of Radiation and Nitrate Availability on the Red Alga <i>Plocamium cartilagineum</i>
by: Bruna Rodrigues Moreira, et al.
Published: (2025-04-01)

Characterization of zebrafish rod and cone photoresponses
by: Shinya Sato, et al.
Published: (2025-04-01)

P23H rhodopsin accumulation causes transient disruptions to synaptic protein levels in rod photoreceptors in a model of retinitis pigmentosa
by: Samantha L. Thompson, et al.
Published: (2025-06-01)

Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions
by: Toshiki Otoda, et al.
Published: (2025-04-01)

Do microglia metabolize fructose in Alzheimer’s disease?
by: Annalise M. Sturno, et al.
Published: (2025-03-01)

Archaeal LOV domains from Lake Diamante: first functional characterization of a halo-adapted photoreceptor
by: Lorena Valle, et al.
Published: (2025-06-01)

Trem2 regulates microglial migratory responses via type I interferon signaling during photoreceptor degeneration
by: Jincan He, et al.
Published: (2025-06-01)

Pyruvate kinase deficiency links metabolic perturbations to neurodegeneration and axonal protection
by: Thomas J. Waller, et al.
Published: (2025-08-01)

Quantitative modeling of rod outer segment phagocytosis and recycling
by: Christina Kiel, et al.
Published: (2025-07-01)

Toxicity of a seafood toxin, domoic acid, in the retina via modulation of the NRF2 and NF-κB pathways
by: Gabriel Mbuta Tchivelekete, et al.
Published: (2025-05-01)

Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation
by: Raghavi Sudharsan, et al.
Published: (2025-07-01)

Towards realistic simulation of disease progression in the visual cortex with CNNs
by: Jasmine A. Moore, et al.
Published: (2025-02-01)

Metabolic Syndrome and Parkinson’s Disease: Two Villains Join Forces
by: Lucas Udovin, et al.
Published: (2025-06-01)

Neuroenergetics of traumatic brain injury
by: Kate Karelina, et al.
Published: (2016-03-01)

Retinal progenitor cells (jCell) for retinitis pigmentosa
by: Jing Yang, et al.
Published: (2025-08-01)

Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy
by: Yaoxiang Sun, et al.
Published: (2025-08-01)

Complex Signaling Networks Underlying Blue-Light-Mediated Floral Transition in Plants
by: Yun Kong, et al.
Published: (2025-05-01)

Dual-targeting CSF1R signaling attenuates neurotoxic myeloid activation and preserves photoreceptors in retinitis pigmentosa
by: Jiangmei Wu, et al.
Published: (2025-07-01)

AAV-mediated transduction of songbird retina
by: Pranav Kumar Seth, et al.
Published: (2025-03-01)

Challenges and Advances in the Production of Transplantable Retinal Tissue from Retinal Organoids
by: Samir Malhotra, et al.
Published: (2025-06-01)

Formoterol Reduces the Pro‐Inflammatory Phenotype by Enhancing the Activity of Glutaminase in Monocyte‐Derived Macrophages in the CVB3‐Induced Viral Myocarditis
by: Quan‐liang Li, et al.
Published: (2024-11-01)