Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats
Neuropathic pain is a public health problem. Although many pharmaceuticals are used to treat neuropathic pain, effective and safe drugs do not yet exist. In this study, we tested nociceptive responses in CCI rats, and ELISA assay was performed to examine the expression of proinflammatory cytokines....
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8894752 |
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| _version_ | 1849400536765300736 |
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| author | Pengfei Gao Jiayu Wang Zhen Su Fayin Li Xianlong Zhang |
| author_facet | Pengfei Gao Jiayu Wang Zhen Su Fayin Li Xianlong Zhang |
| author_sort | Pengfei Gao |
| collection | DOAJ |
| description | Neuropathic pain is a public health problem. Although many pharmaceuticals are used to treat neuropathic pain, effective and safe drugs do not yet exist. In this study, we tested nociceptive responses in CCI rats, and ELISA assay was performed to examine the expression of proinflammatory cytokines. We found that amorfrutins significantly reduce the pain behaviors in CCI rats and suppress the expression of proinflammatory cytokines (TNFα, IL-6, and IL-1β) and chemokines (CCL2/CCR2) in the spinal cord. However, concurrent administration of a PPARγ antagonist, GW9662, reversed the antihyperalgesic effect induced by amorfrutins. The results indicate that amorfrutins inhibit the inflammation and chemokine expression by activating PPARγ, thus relieving neuropathic pain in CCI rats. Therefore, PPARγ-CCL2/CCR2 pathway might represent a new treatment option for neuropathic pain. |
| format | Article |
| id | doaj-art-87415d6f48014ddea71d3b6cd9a6f726 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-87415d6f48014ddea71d3b6cd9a6f7262025-08-20T03:38:01ZengWileyPPAR Research1687-47571687-47652021-01-01202110.1155/2021/88947528894752Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI RatsPengfei Gao0Jiayu Wang1Zhen Su2Fayin Li3Xianlong Zhang4Department of Anesthesiology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, ChinaDepartment of Anesthesiology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, ChinaDepartment of Anesthesiology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, ChinaDepartment of Anesthesiology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, ChinaDepartment of Anesthesiology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, ChinaNeuropathic pain is a public health problem. Although many pharmaceuticals are used to treat neuropathic pain, effective and safe drugs do not yet exist. In this study, we tested nociceptive responses in CCI rats, and ELISA assay was performed to examine the expression of proinflammatory cytokines. We found that amorfrutins significantly reduce the pain behaviors in CCI rats and suppress the expression of proinflammatory cytokines (TNFα, IL-6, and IL-1β) and chemokines (CCL2/CCR2) in the spinal cord. However, concurrent administration of a PPARγ antagonist, GW9662, reversed the antihyperalgesic effect induced by amorfrutins. The results indicate that amorfrutins inhibit the inflammation and chemokine expression by activating PPARγ, thus relieving neuropathic pain in CCI rats. Therefore, PPARγ-CCL2/CCR2 pathway might represent a new treatment option for neuropathic pain.http://dx.doi.org/10.1155/2021/8894752 |
| spellingShingle | Pengfei Gao Jiayu Wang Zhen Su Fayin Li Xianlong Zhang Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats PPAR Research |
| title | Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats |
| title_full | Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats |
| title_fullStr | Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats |
| title_full_unstemmed | Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats |
| title_short | Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats |
| title_sort | amorfrutins relieve neuropathic pain through the pparγ ccl2 axis in cci rats |
| url | http://dx.doi.org/10.1155/2021/8894752 |
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