Association between circulating irisin level and depression: a systematic review and meta-analysis
Background Previous studies have presented controversial results about the association between irisin and depression. This research is designed to explore the circulating irisin levels in depressive patients.Methods From the earliest available records up to 18 July 2024, searches were conducted in d...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2521424 |
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| author | Chengyan Han Zining Zhou Jianxing Zhao Zhouli Shao Peng Sun |
| author_facet | Chengyan Han Zining Zhou Jianxing Zhao Zhouli Shao Peng Sun |
| author_sort | Chengyan Han |
| collection | DOAJ |
| description | Background Previous studies have presented controversial results about the association between irisin and depression. This research is designed to explore the circulating irisin levels in depressive patients.Methods From the earliest available records up to 18 July 2024, searches were conducted in databases of PubMed, Embase, Web of Science, the Cochrane Library, and Scopus, in order to identify the relevant articles assessing the correlation between irisin and depression in humans. Two reviewers screened reports, retrieved and collected data independently.Results Totally, eight articles with 2044 samples (733 depressive patients and 1311 non-depressive individuals) were involved. The results indicated lower circulating irisin levels in depression (standardized mean difference [SMD] = 0.60, 95% confidence interval [CI]: 0.08 to 1.12, p = 0.02). Subgroup analysis revealed decreased irisin levels in depressive Asian patients (SMD = 0.47, 95% CI: 0.05 to 0.90, p = 0.03), sample size greater than 100 participants (SMD = 1.20, 95% CI: 0.48 to 1.93, p = 0.001), ELISA kits not from Phoenix Pharmaceuticals (SMD = 0.47, 95% CI: 0.05 to 0.90, p = 0.03), blood sample of serum (SMD = 0.79, 95% CI: 0.18 to 1.40, p = 0.01), studies with two genders (SMD = 0.85, 95% CI: 0.26 to 1.43, p = 0.005). Moreover, six studies computed the correlation factor (r) values between irisin levels and depressive scores, and the combined findings indicated an inverse correlation for these two variables (r = −0.47, 95% CI: −0.69 to −0.24, p < 0.001).Conclusions The results of this research demonstrated that irisin levels were decreased in depressive patients, and there was a negative correlation between irisin levels and depressive scores, indicating that the lower the circulating irisin level, the more severe the depressive symptoms. |
| format | Article |
| id | doaj-art-87383b4d6f4b49bd92d4cec57d495117 |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-87383b4d6f4b49bd92d4cec57d4951172025-08-20T02:10:19ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2521424Association between circulating irisin level and depression: a systematic review and meta-analysisChengyan Han0Zining Zhou1Jianxing Zhao2Zhouli Shao3Peng Sun4School of Rehabilitation, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaSchool of Rehabilitation, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaSchool of Rehabilitation, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCenter for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital,), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCenter for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital,), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaBackground Previous studies have presented controversial results about the association between irisin and depression. This research is designed to explore the circulating irisin levels in depressive patients.Methods From the earliest available records up to 18 July 2024, searches were conducted in databases of PubMed, Embase, Web of Science, the Cochrane Library, and Scopus, in order to identify the relevant articles assessing the correlation between irisin and depression in humans. Two reviewers screened reports, retrieved and collected data independently.Results Totally, eight articles with 2044 samples (733 depressive patients and 1311 non-depressive individuals) were involved. The results indicated lower circulating irisin levels in depression (standardized mean difference [SMD] = 0.60, 95% confidence interval [CI]: 0.08 to 1.12, p = 0.02). Subgroup analysis revealed decreased irisin levels in depressive Asian patients (SMD = 0.47, 95% CI: 0.05 to 0.90, p = 0.03), sample size greater than 100 participants (SMD = 1.20, 95% CI: 0.48 to 1.93, p = 0.001), ELISA kits not from Phoenix Pharmaceuticals (SMD = 0.47, 95% CI: 0.05 to 0.90, p = 0.03), blood sample of serum (SMD = 0.79, 95% CI: 0.18 to 1.40, p = 0.01), studies with two genders (SMD = 0.85, 95% CI: 0.26 to 1.43, p = 0.005). Moreover, six studies computed the correlation factor (r) values between irisin levels and depressive scores, and the combined findings indicated an inverse correlation for these two variables (r = −0.47, 95% CI: −0.69 to −0.24, p < 0.001).Conclusions The results of this research demonstrated that irisin levels were decreased in depressive patients, and there was a negative correlation between irisin levels and depressive scores, indicating that the lower the circulating irisin level, the more severe the depressive symptoms.https://www.tandfonline.com/doi/10.1080/07853890.2025.2521424Depressionirisinsystematic reviewmeta-analysis |
| spellingShingle | Chengyan Han Zining Zhou Jianxing Zhao Zhouli Shao Peng Sun Association between circulating irisin level and depression: a systematic review and meta-analysis Annals of Medicine Depression irisin systematic review meta-analysis |
| title | Association between circulating irisin level and depression: a systematic review and meta-analysis |
| title_full | Association between circulating irisin level and depression: a systematic review and meta-analysis |
| title_fullStr | Association between circulating irisin level and depression: a systematic review and meta-analysis |
| title_full_unstemmed | Association between circulating irisin level and depression: a systematic review and meta-analysis |
| title_short | Association between circulating irisin level and depression: a systematic review and meta-analysis |
| title_sort | association between circulating irisin level and depression a systematic review and meta analysis |
| topic | Depression irisin systematic review meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2521424 |
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