Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics
ABSTRACT Background Cerebrospinal fluid (CSF) collection is routinely performed in dogs with neurological disorders. Little is known about the rate of major complications associated with CSF collection. Objectives Determine the number of dogs experiencing a major complication secondary to CSF collec...
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| Format: | Article |
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Wiley
2025-07-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.70165 |
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| author | Cecilia‐Gabriella Danciu Alana McCarthy Abbe Crawford |
| author_facet | Cecilia‐Gabriella Danciu Alana McCarthy Abbe Crawford |
| author_sort | Cecilia‐Gabriella Danciu |
| collection | DOAJ |
| description | ABSTRACT Background Cerebrospinal fluid (CSF) collection is routinely performed in dogs with neurological disorders. Little is known about the rate of major complications associated with CSF collection. Objectives Determine the number of dogs experiencing a major complication secondary to CSF collection in a single referral hospital. Animals Eleven dogs. Methods Single‐center, retrospective description of the number and nature of major complications encountered during or after CSF collection in dogs. Results From 7545 CSF collections performed between 1998 and 2024, 11 dogs (0.15%) experienced a major complication. Eight of these dogs had abnormal mentation on presentation. The most common neuroanatomical localization was multifocal (5/11). Nine dogs underwent magnetic resonance imaging (MRI) of the head and one dog had radiographs of the cervical vertebral column before CSF collection. The most common MRI findings included effacement of the cerebral sulci (7/9) and dilatation of the ventricular system (5/9). Cerebrospinal fluid collection was performed in 11 dogs, of which 3 were unsuccessful. Analysis of CSF aided in the diagnosis of meningoencephalitis of unknown origin (3/8), cryptococcosis (1/8), lymphoma (1/8), and results were normal in one and non‐specific in two dogs. Eight dogs were euthanized after failure to recover spontaneous ventilation (6), cardiopulmonary arrest (1) or severe neurological deterioration (1). One dog died during cardiopulmonary resuscitation. Repeat MRI after CSF collection identified caudal transtentorial and foramen magnum herniation in one dog. Two dogs survived to hospital discharge but with permanent neurological deficits. Conclusion The frequency of major complications following CSF collection was low, but the associated mortality was high. Abnormal mentation and MRI evidence of cerebral cortical swelling were commonly detected before CSF collection in dogs experiencing complications. |
| format | Article |
| id | doaj-art-8733f9e31a6b4aa8ac13b8c7e20d0fcb |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-8733f9e31a6b4aa8ac13b8c7e20d0fcb2025-08-20T03:34:31ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-07-01394n/an/a10.1111/jvim.70165Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging CharacteristicsCecilia‐Gabriella Danciu0Alana McCarthy1Abbe Crawford2Veterinary Clinical Science and Services, Royal Veterinary College University of London Hatfield UKVeterinary Clinical Science and Services, Royal Veterinary College University of London Hatfield UKVeterinary Clinical Science and Services, Royal Veterinary College University of London Hatfield UKABSTRACT Background Cerebrospinal fluid (CSF) collection is routinely performed in dogs with neurological disorders. Little is known about the rate of major complications associated with CSF collection. Objectives Determine the number of dogs experiencing a major complication secondary to CSF collection in a single referral hospital. Animals Eleven dogs. Methods Single‐center, retrospective description of the number and nature of major complications encountered during or after CSF collection in dogs. Results From 7545 CSF collections performed between 1998 and 2024, 11 dogs (0.15%) experienced a major complication. Eight of these dogs had abnormal mentation on presentation. The most common neuroanatomical localization was multifocal (5/11). Nine dogs underwent magnetic resonance imaging (MRI) of the head and one dog had radiographs of the cervical vertebral column before CSF collection. The most common MRI findings included effacement of the cerebral sulci (7/9) and dilatation of the ventricular system (5/9). Cerebrospinal fluid collection was performed in 11 dogs, of which 3 were unsuccessful. Analysis of CSF aided in the diagnosis of meningoencephalitis of unknown origin (3/8), cryptococcosis (1/8), lymphoma (1/8), and results were normal in one and non‐specific in two dogs. Eight dogs were euthanized after failure to recover spontaneous ventilation (6), cardiopulmonary arrest (1) or severe neurological deterioration (1). One dog died during cardiopulmonary resuscitation. Repeat MRI after CSF collection identified caudal transtentorial and foramen magnum herniation in one dog. Two dogs survived to hospital discharge but with permanent neurological deficits. Conclusion The frequency of major complications following CSF collection was low, but the associated mortality was high. Abnormal mentation and MRI evidence of cerebral cortical swelling were commonly detected before CSF collection in dogs experiencing complications.https://doi.org/10.1111/jvim.70165canineCSFintracranial pressuremagnetic resonance imagingmortality |
| spellingShingle | Cecilia‐Gabriella Danciu Alana McCarthy Abbe Crawford Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics Journal of Veterinary Internal Medicine canine CSF intracranial pressure magnetic resonance imaging mortality |
| title | Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics |
| title_full | Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics |
| title_fullStr | Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics |
| title_full_unstemmed | Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics |
| title_short | Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics |
| title_sort | major complications associated with cerebrospinal fluid collection in 11 dogs clinical presentation and imaging characteristics |
| topic | canine CSF intracranial pressure magnetic resonance imaging mortality |
| url | https://doi.org/10.1111/jvim.70165 |
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