Clinical characteristics of cerebral venous thrombosis in patients with systemic lupus erythematosus
Objective To analyze the clinical manifestations, imaging features, treatment and prognosis of patients with systemic lupus erythematosus (SLE) combined with cerebral venous thrombosis (CVT). Methods and Results Clinical data of 19 patients with SLE combined with CVT (SLE combined with CVT group) an...
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Tianjin Huanhu Hospital
2025-06-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/3048 |
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| author | LIAO Qiu-ju YANG Xiao-yi ZHAO Yi SU Li |
| author_facet | LIAO Qiu-ju YANG Xiao-yi ZHAO Yi SU Li |
| author_sort | LIAO Qiu-ju |
| collection | DOAJ |
| description | Objective To analyze the clinical manifestations, imaging features, treatment and prognosis of patients with systemic lupus erythematosus (SLE) combined with cerebral venous thrombosis (CVT). Methods and Results Clinical data of 19 patients with SLE combined with CVT (SLE combined with CVT group) and 38 age and sex matched patients with SLE without CVT (SLE without CVT group) hospitalized in Xuanwu Hospital, Capital Medical University from January 2013 to December 2024 were retrospectively analyzed. SLE combined with CVT group had higher D-dimer (P = 0.001), lupus anticoagulant (P = 0.001), and Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2000) at admission (P = 0.000) compared with SLE without CVT group. In SLE combined with CVT group, headache (18/19) was the most common neurological symptom. Cerebrospinal fluid (CSF) pressure increased in 14 cases (14/16). The most common cases of thrombosis were transversal sinus (17/19) and sigmoid sinus (17/19). Seventeen cases (17/19) had ≥ 2 venous sinuses involved. Twelve cases had other sites venous thrombosis occurred simultaneously. All patients of SLE combined with CVT group were treated with glucocorticoids, immunosuppressants and anticoagulation therapy. The average follow-up period was (77.14 ± 33.46) months. During the follow-up, 16 cases improved, one case died of concurrent infection, and 2 cases were lost to follow-up. Conclusions CVT is a rare and severity complication of SLE. Headache is the most common neurological symptom, and transversal sinus and sigmoid sinus are the most common sites of thrombosis. For patients of SLE combined with CVT, treatments such as glucocorticoids and immunosuppressants need to be strengthened after venous sinus mechanical thrombectomy. Early recognition and active treatment can obtain good curative effect. |
| format | Article |
| id | doaj-art-873024cb9d234418b3f871b99975bb39 |
| institution | Kabale University |
| issn | 1672-6731 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj-art-873024cb9d234418b3f871b99975bb392025-08-20T03:29:58ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312025-06-0125650350810.3969/j.issn.1672⁃6731.2025.06.008Clinical characteristics of cerebral venous thrombosis in patients with systemic lupus erythematosusLIAO Qiu-ju0YANG Xiao-yi1ZHAO Yi2SU Li3Department of Rheumatology & Allergy, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Rheumatology & Allergy, Xiong'an Xuanwu Hospital, Xiong'an 071702, Hebei, ChinaDepartment of Rheumatology & Allergy, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Rheumatology & Allergy, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaObjective To analyze the clinical manifestations, imaging features, treatment and prognosis of patients with systemic lupus erythematosus (SLE) combined with cerebral venous thrombosis (CVT). Methods and Results Clinical data of 19 patients with SLE combined with CVT (SLE combined with CVT group) and 38 age and sex matched patients with SLE without CVT (SLE without CVT group) hospitalized in Xuanwu Hospital, Capital Medical University from January 2013 to December 2024 were retrospectively analyzed. SLE combined with CVT group had higher D-dimer (P = 0.001), lupus anticoagulant (P = 0.001), and Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2000) at admission (P = 0.000) compared with SLE without CVT group. In SLE combined with CVT group, headache (18/19) was the most common neurological symptom. Cerebrospinal fluid (CSF) pressure increased in 14 cases (14/16). The most common cases of thrombosis were transversal sinus (17/19) and sigmoid sinus (17/19). Seventeen cases (17/19) had ≥ 2 venous sinuses involved. Twelve cases had other sites venous thrombosis occurred simultaneously. All patients of SLE combined with CVT group were treated with glucocorticoids, immunosuppressants and anticoagulation therapy. The average follow-up period was (77.14 ± 33.46) months. During the follow-up, 16 cases improved, one case died of concurrent infection, and 2 cases were lost to follow-up. Conclusions CVT is a rare and severity complication of SLE. Headache is the most common neurological symptom, and transversal sinus and sigmoid sinus are the most common sites of thrombosis. For patients of SLE combined with CVT, treatments such as glucocorticoids and immunosuppressants need to be strengthened after venous sinus mechanical thrombectomy. Early recognition and active treatment can obtain good curative effect.http://www.cjcnn.org/index.php/cjcnn/article/view/3048lupus erythematosus， systemicvenous thrombosiscerebral veins |
| spellingShingle | LIAO Qiu-ju YANG Xiao-yi ZHAO Yi SU Li Clinical characteristics of cerebral venous thrombosis in patients with systemic lupus erythematosus Chinese Journal of Contemporary Neurology and Neurosurgery lupus erythematosus， systemic venous thrombosis cerebral veins |
| title | Clinical characteristics of cerebral venous thrombosis in patients with systemic lupus erythematosus |
| title_full | Clinical characteristics of cerebral venous thrombosis in patients with systemic lupus erythematosus |
| title_fullStr | Clinical characteristics of cerebral venous thrombosis in patients with systemic lupus erythematosus |
| title_full_unstemmed | Clinical characteristics of cerebral venous thrombosis in patients with systemic lupus erythematosus |
| title_short | Clinical characteristics of cerebral venous thrombosis in patients with systemic lupus erythematosus |
| title_sort | clinical characteristics of cerebral venous thrombosis in patients with systemic lupus erythematosus |
| topic | lupus erythematosus， systemic venous thrombosis cerebral veins |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/3048 |
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