Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantification of Bone Marrow Aging and Radiation Effects in Mice

Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantification of Bone Marrow Aging and Radiation Effects in Mice

Background: Bone marrow (BM) adipocytes play a critical role in the progression of both solid tumor metastases and expansion of hematological malignancies across a spectrum of ages, from pediatric to aging populations. Single-point biopsies remain the gold standard for monitoring BM diseases, includ...

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Main Authors: Hemendra Ghimire, Malakeh Malekzadeh, Ji Eun Lim, Srideshikan Sargur Madabushi, Marco Andrea Zampini, Angela Camacho, Weidong Hu, Natalia Baran, Guy Storme, Monzr M. Al Malki, Susanta K. Hui
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Bioengineering
Subjects:
bone marrow imaging
proton density fat fraction
hematological malignancies
MRI biomarkers
histological validation
Online Access:https://www.mdpi.com/2306-5354/12/4/349
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