Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases

Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases

Abstract Hemoglobin (Hb) is well known for transporting oxygen in the blood, but its role in the brain remains poorly understood. Here, we identified Hb in the cytosol, mitochondria, and nuclei of hippocampal and substantia nigra astrocytes and dopaminergic neurons. As a pseudoperoxidase, Hb decompo...

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Main Authors: Woojin Won, Elijah Hwejin Lee, Lizaveta Gotina, Heejung Chun, Jae-Hun Lee, Mridula Bhalla, Uiyeol Park, Daeun Kim, Tai Young Kim, Ji Won Choi, Yoowon Kim, Sun Jun Park, Jiwoon Lim, Jong-Hyun Park, Hyeon Jeong Kim, Jun Young Heo, Woosuk Chung, Myung Jin Oh, Hyun Joo An, Junghee Lee, Soo-Jin Oh, Hoon Ryu, Ae Nim Pae, Ki Duk Park, C. Justin Lee
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02366-w
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https://doi.org/10.1038/s41392-025-02366-w

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