Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice
Aims: Nanoplastics (NPs) are emerging organic pollutants generated by plastic degradation and are ubiquitous in the environment. They can be accumulated through the food webs and enter the human body through dietary intake, posing health risks. The main target organs of NP accumulation are the lungs...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132500048X |
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| author | Ziyi Xiong Qiling Kong Juan Hua Qi Chen Dandan Wang |
| author_facet | Ziyi Xiong Qiling Kong Juan Hua Qi Chen Dandan Wang |
| author_sort | Ziyi Xiong |
| collection | DOAJ |
| description | Aims: Nanoplastics (NPs) are emerging organic pollutants generated by plastic degradation and are ubiquitous in the environment. They can be accumulated through the food webs and enter the human body through dietary intake, posing health risks. The main target organs of NP accumulation are the lungs, liver, heart, and kidneys. However, compared with that for other target organs, research on the adverse effects of NPs on the heart is limited. We aimed to investigate the toxic effects of polystyrene NPs on the heart and the associated mechanisms. Methods and results: Forty-eight male C57BL/6 mice were randomly divided into control and experimental groups. Three experimental groups were exposed to NP doses of 30, 60, and 100 mg/L for 42 days. The mice exhibited enlarged ventricular chambers, thinned ventricular walls, decreased ejection fraction, reduced heart rate, and lowered blood pressure with increasing PS-NP concentration. In vitro experiments using H9C2 myocardial cells demonstrated that PS-NPs activate the TNF-α/NF-κB and P38/MAPK signaling pathways and thereby induce inflammatory infiltration and oxidative stress. This can lead to myocardial fibrosis and apoptosis and thus eccentric cardiac hypertrophy and impaired contractile function. Conclusions: This study provides new evidence regarding the potential mechanisms of PS-NP cardiovascular toxicity as well as insights into the diagnosis and treatment of unexplained dilated cardiomyopathy in clinical settings. |
| format | Article |
| id | doaj-art-87246f15e6b24b7f8ba9af78b1f2b55e |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-87246f15e6b24b7f8ba9af78b1f2b55e2025-02-12T05:30:04ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117712Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in miceZiyi Xiong0Qiling Kong1Juan Hua2Qi Chen3Dandan Wang4Department of Cardiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province 330006, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province 330006, ChinaDepartment of Cardiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province 330006, ChinaCorrespondence to: Department of Cardiology, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province 330006, China.; Department of Cardiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province 330006, ChinaCorrespondence to: Department of Cardiology, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province 330006, China.; Department of Cardiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province 330006, ChinaAims: Nanoplastics (NPs) are emerging organic pollutants generated by plastic degradation and are ubiquitous in the environment. They can be accumulated through the food webs and enter the human body through dietary intake, posing health risks. The main target organs of NP accumulation are the lungs, liver, heart, and kidneys. However, compared with that for other target organs, research on the adverse effects of NPs on the heart is limited. We aimed to investigate the toxic effects of polystyrene NPs on the heart and the associated mechanisms. Methods and results: Forty-eight male C57BL/6 mice were randomly divided into control and experimental groups. Three experimental groups were exposed to NP doses of 30, 60, and 100 mg/L for 42 days. The mice exhibited enlarged ventricular chambers, thinned ventricular walls, decreased ejection fraction, reduced heart rate, and lowered blood pressure with increasing PS-NP concentration. In vitro experiments using H9C2 myocardial cells demonstrated that PS-NPs activate the TNF-α/NF-κB and P38/MAPK signaling pathways and thereby induce inflammatory infiltration and oxidative stress. This can lead to myocardial fibrosis and apoptosis and thus eccentric cardiac hypertrophy and impaired contractile function. Conclusions: This study provides new evidence regarding the potential mechanisms of PS-NP cardiovascular toxicity as well as insights into the diagnosis and treatment of unexplained dilated cardiomyopathy in clinical settings.http://www.sciencedirect.com/science/article/pii/S014765132500048XNanoplasticMicroplasticCardiotoxicityInflammatory infiltrationOxidative stress |
| spellingShingle | Ziyi Xiong Qiling Kong Juan Hua Qi Chen Dandan Wang Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice Ecotoxicology and Environmental Safety Nanoplastic Microplastic Cardiotoxicity Inflammatory infiltration Oxidative stress |
| title | Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice |
| title_full | Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice |
| title_fullStr | Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice |
| title_full_unstemmed | Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice |
| title_short | Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice |
| title_sort | cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice |
| topic | Nanoplastic Microplastic Cardiotoxicity Inflammatory infiltration Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S014765132500048X |
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