The effects of disturbance on hypothalamus-pituitary-thyroid axis in zebrafish larvae after exposure to polyvinyl alcohol
In recent years, considerable concerns have been raised regarding environmental pollution caused by water-soluble polymers (WSPs). Polyvinyl alcohol (PVA), used in the textile industry and in the manufacture of medical consumables, is one type of WSPs. After use, PVA is discharged and enters aquatic...
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Elsevier
2024-12-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324014726 |
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| author | Fei-Yang Zhang Ya Fang Cao-Xu Zhang Hai-Yang Zhang Mei Dong Kai-Wen Zhang Chen-yang Wu Huai-Dong Song Gang Chen |
| author_facet | Fei-Yang Zhang Ya Fang Cao-Xu Zhang Hai-Yang Zhang Mei Dong Kai-Wen Zhang Chen-yang Wu Huai-Dong Song Gang Chen |
| author_sort | Fei-Yang Zhang |
| collection | DOAJ |
| description | In recent years, considerable concerns have been raised regarding environmental pollution caused by water-soluble polymers (WSPs). Polyvinyl alcohol (PVA), used in the textile industry and in the manufacture of medical consumables, is one type of WSPs. After use, PVA is discharged and enters aquatic ecosystems, but most of it cannot be completely biodegraded in the environment. In this study, we investigated the effects of PVA on developmental toxicity and thyroid endocrine disruption using a zebrafish (Danio rerio) model. We treated zebrafish embryos with 10 g/L and 5 mg/L PVA for 96 h and found that the proportion of coagulated embryos significantly increased, resulting in a remarkable decrease in hatching rate and larval survival. The body length of zebrafish larvae in the exposed group was remarkably shorter than that of the control group (Control: 3.64 ± 0.03 mm vs. 10 g/L PVA: 3.46 ± 0.03 mm; p=0.001). Compared to the control group, the levels of T3 and T4 in embryos of the exposed group were significantly lower, while thyroid stimulating hormone (TSH) levels were significantly increased. Notable up-regulation of trh, tshβ, and tshr genes, as well as down-regulation of trα , tg, ttr, dio1, and dio2 genes, were observed in embryos of the exposed group. Collectively, these findings suggest that PVA negatively influences the development and function of the thyroid gland during zebrafish embryogenesis. These effects may be partly attributed to the disruption of hypothalamic-pituitary-thyroid (HPT) axis regulation. Therefore, raising awareness about the possible thyroid toxicity associated with PVA is crucial. |
| format | Article |
| id | doaj-art-8723d2492f7d43ddbf64fe95a8e153e7 |
| institution | OA Journals |
| issn | 0147-6513 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-8723d2492f7d43ddbf64fe95a8e153e72025-08-20T02:21:04ZengElsevierEcotoxicology and Environmental Safety0147-65132024-12-0128811739610.1016/j.ecoenv.2024.117396The effects of disturbance on hypothalamus-pituitary-thyroid axis in zebrafish larvae after exposure to polyvinyl alcoholFei-Yang Zhang0Ya Fang1Cao-Xu Zhang2Hai-Yang Zhang3Mei Dong4Kai-Wen Zhang5Chen-yang Wu6Huai-Dong Song7Gang Chen8Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China; Department of Endocrinology, Fujian Provincial Hospital, Fuzhou, China; Department of Endocrinology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, ChinaDepartment of Endocrinology and Metabolism, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, ChinaDepartment of Respiratory and Critical Care Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaThe Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People’s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaZhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, ChinaThe Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People’s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaThe Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics & Endocrinology, Shanghai Ninth People’s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: No. 134 East Street, Gulou District, Fuzhou, Fujian Province, China.Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China; Department of Endocrinology, Fujian Provincial Hospital, Fuzhou, China; Department of Endocrinology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China; Correspondence to: No. 134 East Street, Gulou District, Fuzhou, Fujian Province, China.In recent years, considerable concerns have been raised regarding environmental pollution caused by water-soluble polymers (WSPs). Polyvinyl alcohol (PVA), used in the textile industry and in the manufacture of medical consumables, is one type of WSPs. After use, PVA is discharged and enters aquatic ecosystems, but most of it cannot be completely biodegraded in the environment. In this study, we investigated the effects of PVA on developmental toxicity and thyroid endocrine disruption using a zebrafish (Danio rerio) model. We treated zebrafish embryos with 10 g/L and 5 mg/L PVA for 96 h and found that the proportion of coagulated embryos significantly increased, resulting in a remarkable decrease in hatching rate and larval survival. The body length of zebrafish larvae in the exposed group was remarkably shorter than that of the control group (Control: 3.64 ± 0.03 mm vs. 10 g/L PVA: 3.46 ± 0.03 mm; p=0.001). Compared to the control group, the levels of T3 and T4 in embryos of the exposed group were significantly lower, while thyroid stimulating hormone (TSH) levels were significantly increased. Notable up-regulation of trh, tshβ, and tshr genes, as well as down-regulation of trα , tg, ttr, dio1, and dio2 genes, were observed in embryos of the exposed group. Collectively, these findings suggest that PVA negatively influences the development and function of the thyroid gland during zebrafish embryogenesis. These effects may be partly attributed to the disruption of hypothalamic-pituitary-thyroid (HPT) axis regulation. Therefore, raising awareness about the possible thyroid toxicity associated with PVA is crucial.http://www.sciencedirect.com/science/article/pii/S0147651324014726WSPsPVAThyroidZebrafishDevelopmental toxicity |
| spellingShingle | Fei-Yang Zhang Ya Fang Cao-Xu Zhang Hai-Yang Zhang Mei Dong Kai-Wen Zhang Chen-yang Wu Huai-Dong Song Gang Chen The effects of disturbance on hypothalamus-pituitary-thyroid axis in zebrafish larvae after exposure to polyvinyl alcohol Ecotoxicology and Environmental Safety WSPs PVA Thyroid Zebrafish Developmental toxicity |
| title | The effects of disturbance on hypothalamus-pituitary-thyroid axis in zebrafish larvae after exposure to polyvinyl alcohol |
| title_full | The effects of disturbance on hypothalamus-pituitary-thyroid axis in zebrafish larvae after exposure to polyvinyl alcohol |
| title_fullStr | The effects of disturbance on hypothalamus-pituitary-thyroid axis in zebrafish larvae after exposure to polyvinyl alcohol |
| title_full_unstemmed | The effects of disturbance on hypothalamus-pituitary-thyroid axis in zebrafish larvae after exposure to polyvinyl alcohol |
| title_short | The effects of disturbance on hypothalamus-pituitary-thyroid axis in zebrafish larvae after exposure to polyvinyl alcohol |
| title_sort | effects of disturbance on hypothalamus pituitary thyroid axis in zebrafish larvae after exposure to polyvinyl alcohol |
| topic | WSPs PVA Thyroid Zebrafish Developmental toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324014726 |
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