Microbiology and Antibiotic Susceptibility Pattern in Congenital Nasolacrimal Duct Obstruction
Purpose: To analyze the microbiological spectrum and antibiotic sensitivity in children with congenital nasolacrimal duct obstruction (CNLDO) and determine the empirical drug of choice. Methodology: A prospective study included 198 eyes of 170 patients aged 0–5 years with CNLDO, who were regurgitati...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Delhi Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/DLJO.DLJO_28_24 |
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| author | Maneksha Velu K. S. Aparna |
| author_facet | Maneksha Velu K. S. Aparna |
| author_sort | Maneksha Velu |
| collection | DOAJ |
| description | Purpose:
To analyze the microbiological spectrum and antibiotic sensitivity in children with congenital nasolacrimal duct obstruction (CNLDO) and determine the empirical drug of choice.
Methodology:
A prospective study included 198 eyes of 170 patients aged 0–5 years with CNLDO, who were regurgitation on pressure over lacrimal sac positive. Conjunctival swabs after applying pressure over the lacrimal sac were sent for microbiology. Antibiotic susceptibility testing was done by Kirby–Bauer disc diffusion method.
Results:
94.94% of samples were culture positive and 48.4% were Gram-positive. The most common Gram-positive and Gram-negative organisms isolated were Streptococcus pneumoniae and Haemophilus influenzae, respectively. Gram-positive organisms showed the highest sensitivity to chloramphenicol and Gram-negatives to amikacin. Both isolates were susceptible to ofloxacin and gatifloxacin. Eighty-seven eyes underwent probing with overall success rate of 83.91%.
Conclusions:
There was a Gram-positive predominance in CNLDO. Based on our results, fluoroquinolone drops are a good option in the treatment of cases with CNLDO. |
| format | Article |
| id | doaj-art-871dd00a56f6461c9240d482aba213bc |
| institution | DOAJ |
| issn | 0972-0200 2454-2784 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delhi Journal of Ophthalmology |
| spelling | doaj-art-871dd00a56f6461c9240d482aba213bc2025-08-20T02:44:23ZengWolters Kluwer Medknow PublicationsDelhi Journal of Ophthalmology0972-02002454-27842025-04-0135210711210.4103/DLJO.DLJO_28_24Microbiology and Antibiotic Susceptibility Pattern in Congenital Nasolacrimal Duct ObstructionManeksha VeluK. S. AparnaPurpose: To analyze the microbiological spectrum and antibiotic sensitivity in children with congenital nasolacrimal duct obstruction (CNLDO) and determine the empirical drug of choice. Methodology: A prospective study included 198 eyes of 170 patients aged 0–5 years with CNLDO, who were regurgitation on pressure over lacrimal sac positive. Conjunctival swabs after applying pressure over the lacrimal sac were sent for microbiology. Antibiotic susceptibility testing was done by Kirby–Bauer disc diffusion method. Results: 94.94% of samples were culture positive and 48.4% were Gram-positive. The most common Gram-positive and Gram-negative organisms isolated were Streptococcus pneumoniae and Haemophilus influenzae, respectively. Gram-positive organisms showed the highest sensitivity to chloramphenicol and Gram-negatives to amikacin. Both isolates were susceptible to ofloxacin and gatifloxacin. Eighty-seven eyes underwent probing with overall success rate of 83.91%. Conclusions: There was a Gram-positive predominance in CNLDO. Based on our results, fluoroquinolone drops are a good option in the treatment of cases with CNLDO.https://journals.lww.com/10.4103/DLJO.DLJO_28_24antibiotic susceptibility in congenital nasolacrimal duct obstructioncongenital nasolacrimal duct obstructionmicrobiology in congenital nasolacrimal duct obstruction |
| spellingShingle | Maneksha Velu K. S. Aparna Microbiology and Antibiotic Susceptibility Pattern in Congenital Nasolacrimal Duct Obstruction Delhi Journal of Ophthalmology antibiotic susceptibility in congenital nasolacrimal duct obstruction congenital nasolacrimal duct obstruction microbiology in congenital nasolacrimal duct obstruction |
| title | Microbiology and Antibiotic Susceptibility Pattern in Congenital Nasolacrimal Duct Obstruction |
| title_full | Microbiology and Antibiotic Susceptibility Pattern in Congenital Nasolacrimal Duct Obstruction |
| title_fullStr | Microbiology and Antibiotic Susceptibility Pattern in Congenital Nasolacrimal Duct Obstruction |
| title_full_unstemmed | Microbiology and Antibiotic Susceptibility Pattern in Congenital Nasolacrimal Duct Obstruction |
| title_short | Microbiology and Antibiotic Susceptibility Pattern in Congenital Nasolacrimal Duct Obstruction |
| title_sort | microbiology and antibiotic susceptibility pattern in congenital nasolacrimal duct obstruction |
| topic | antibiotic susceptibility in congenital nasolacrimal duct obstruction congenital nasolacrimal duct obstruction microbiology in congenital nasolacrimal duct obstruction |
| url | https://journals.lww.com/10.4103/DLJO.DLJO_28_24 |
| work_keys_str_mv | AT manekshavelu microbiologyandantibioticsusceptibilitypatternincongenitalnasolacrimalductobstruction AT ksaparna microbiologyandantibioticsusceptibilitypatternincongenitalnasolacrimalductobstruction |