Reduced cardiovascular events through dynamic lifestyle modification in individuals with prediabetes or prehypertension in Korea: a nationwide cohort study
Objectives: There is limited knowledge regarding the impact of lifestyle changes on cardiovascular events and mortality among individuals with prehypertension or prediabetes. Methods: This was a serial retrospective cohort study utilizing data...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ewha Womans University College of Medicine
2024-10-01
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| Series: | The Ewha Medical Journal |
| Subjects: | |
| Online Access: | http://www.e-emj.org/archive/view_article?pid=emj-47-4-63 |
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| Summary: | Objectives: There is limited knowledge regarding the impact of
lifestyle changes on cardiovascular events and mortality among individuals with
prehypertension or prediabetes.
Methods: This was a serial retrospective cohort study utilizing data
from the Korean National Health Insurance Service Health Screening Cohort. The
primary outcome considered in the study was major adverse cardiovascular events
(MACE).
Results: A higher risk of MACE was found in men with prehypertension
whose unhealthy lifestyle deteriorated (hazard ratio [HR], 1.13; 95% CI,
1.04–1.23; P=0.004), those who gained weight (HR, 1.15; 95% CI,
1.03–1.28; P=0.010), and those who began smoking (HR, 1.34; 95% CI,
1.17–1.55; P<0.001). Conversely, a reduced risk of MACE was
observed in men with prehypertension who improved their unhealthy lifestyle,
quit smoking, reduced alcohol consumption, or increased the frequency of
physical activity. In men with prediabetes, the risk of MACE was higher in those
whose unhealthy lifestyle worsened (HR, 1.23; 95% CI, 1.12–1.35;
P<0.001), those who gained weight (HR, 1.19; 95% CI, 1.06–1.33;
P=0.003), those who started smoking (HR, 1.41; 95% CI, 1.22–1.64;
P<0.001), and those who decreased their physical activity frequency (HR,
1.21; 95% CI, 1.09–1.35; P<0.001).
Conclusion: Preventive lifestyle changes reduce cardiovascular
events and mortality, particularly in men at risk of developing hypertension or
type 2 diabetes. |
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| ISSN: | 2234-2591 |