The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors
Abstract Purpose The utilization of radiotherapy is a prevalent therapeutic intervention for thyroid malignancies, although its potential implications for cerebrovascular disease are still not comprehensively elucidated. Consequently, our objective was to explore the associated factors, particularly...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-07-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-03041-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849768968108113920 |
|---|---|
| author | Xianghong Wang Xian Yang Ruxin Wang Chuanchuan Sun Hongyun Lu |
| author_facet | Xianghong Wang Xian Yang Ruxin Wang Chuanchuan Sun Hongyun Lu |
| author_sort | Xianghong Wang |
| collection | DOAJ |
| description | Abstract Purpose The utilization of radiotherapy is a prevalent therapeutic intervention for thyroid malignancies, although its potential implications for cerebrovascular disease are still not comprehensively elucidated. Consequently, our objective was to explore the associated factors, particularly the additional influences, of radiotherapy on cerebrovascular mortality among individuals diagnosed with thyroid malignancies, in order to provide valuable clinical insights for management Methods In this study, we used the Surveillance, Epidemiology, and End Results (SEER) database to investigate the impact of radiotherapy on cerebrovascular death in patients diagnosed with thyroid malignancies, as well as to identify the factors that influence cerebrovascular death. To achieve this, we employed the COX proportional risk regression model for both single and multiple factor analysis to investigate the influence of various factors on cerebrovascular death. Additionally, we utilized propensity score matching (PSM) to adjust for confounding factors and minimize bias in baseline characteristics. Results Our study encompassed a cohort of 110,464 individuals who received a diagnosis of thyroid malignancies spanning the years from 1992 to 2019. Our meticulous analysis revealed that, prior to PSM, no significant association existed between radiation therapy (HR 0.906, 95% CI 0.750–1.095, p = 0.309] vs. no versus non-radiation therapy and the risk of cerebrovascular mortality in patients with thyroid malignant tumors. However, subsequent to PSM, the utilization of beam radiation (HR 2.034, 95% CI 1.121–3.692, p = 0.020) was discovered to confer an elevated risk of cerebrovascular mortality in patients diagnosed with thyroid malignancies, while other modalities of radiation therapy did not exhibit a statistically significant difference compared to non-radiation therapy. Furthermore, our investigation identified several noteworthy risk factors for cerebrovascular mortality, including advanced age at the time of diagnosis (HR 1.132, 95% CI 1.122–1.143, p < 0.001), male gender (HR = 1.347, 95% CI = 1.054–1.721, p = 0.017), African ethnicity (HR 1.813, 95% CI 1.152–2.854, p = 0.010), and Combined Summary Stage (distance) (HR 2.171, 95% CI 1.250–3.770, p < 0.006). Conclusion Our study results indicate that the additional impact of radiation on cerebrovascular outcomes varies among different types of radiation therapy. Specifically, “beam radiation” emerges as a significant risk factor for cerebrovascular mortality, while other radiation therapy methods do not appear to significantly increase this risk. These results particularly emphasize that patients with cerebrovascular risk factors (older age of diagnosis, Black ethnicity, male) should avoid beam radiotherapy methods. These results have important implications for clinicians as they can enable informed choice of appropriate radiotherapy for patients with thyroid malignancies, ultimately improving patient outcomes. |
| format | Article |
| id | doaj-art-870e249a8a8f469bab3f20f0885b45ea |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-870e249a8a8f469bab3f20f0885b45ea2025-08-20T03:03:37ZengSpringerDiscover Oncology2730-60112025-07-0116111410.1007/s12672-025-03041-wThe impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumorsXianghong Wang0Xian Yang1Ruxin Wang2Chuanchuan Sun3Hongyun Lu4 Department of Endocrinology, Wuhan Fourth HospitalDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan UniversityDepartment of Cardiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Nephrology, The First Affiliated Hospital of Jinan University Department of Endocrinology and Metabolism, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University)Abstract Purpose The utilization of radiotherapy is a prevalent therapeutic intervention for thyroid malignancies, although its potential implications for cerebrovascular disease are still not comprehensively elucidated. Consequently, our objective was to explore the associated factors, particularly the additional influences, of radiotherapy on cerebrovascular mortality among individuals diagnosed with thyroid malignancies, in order to provide valuable clinical insights for management Methods In this study, we used the Surveillance, Epidemiology, and End Results (SEER) database to investigate the impact of radiotherapy on cerebrovascular death in patients diagnosed with thyroid malignancies, as well as to identify the factors that influence cerebrovascular death. To achieve this, we employed the COX proportional risk regression model for both single and multiple factor analysis to investigate the influence of various factors on cerebrovascular death. Additionally, we utilized propensity score matching (PSM) to adjust for confounding factors and minimize bias in baseline characteristics. Results Our study encompassed a cohort of 110,464 individuals who received a diagnosis of thyroid malignancies spanning the years from 1992 to 2019. Our meticulous analysis revealed that, prior to PSM, no significant association existed between radiation therapy (HR 0.906, 95% CI 0.750–1.095, p = 0.309] vs. no versus non-radiation therapy and the risk of cerebrovascular mortality in patients with thyroid malignant tumors. However, subsequent to PSM, the utilization of beam radiation (HR 2.034, 95% CI 1.121–3.692, p = 0.020) was discovered to confer an elevated risk of cerebrovascular mortality in patients diagnosed with thyroid malignancies, while other modalities of radiation therapy did not exhibit a statistically significant difference compared to non-radiation therapy. Furthermore, our investigation identified several noteworthy risk factors for cerebrovascular mortality, including advanced age at the time of diagnosis (HR 1.132, 95% CI 1.122–1.143, p < 0.001), male gender (HR = 1.347, 95% CI = 1.054–1.721, p = 0.017), African ethnicity (HR 1.813, 95% CI 1.152–2.854, p = 0.010), and Combined Summary Stage (distance) (HR 2.171, 95% CI 1.250–3.770, p < 0.006). Conclusion Our study results indicate that the additional impact of radiation on cerebrovascular outcomes varies among different types of radiation therapy. Specifically, “beam radiation” emerges as a significant risk factor for cerebrovascular mortality, while other radiation therapy methods do not appear to significantly increase this risk. These results particularly emphasize that patients with cerebrovascular risk factors (older age of diagnosis, Black ethnicity, male) should avoid beam radiotherapy methods. These results have important implications for clinicians as they can enable informed choice of appropriate radiotherapy for patients with thyroid malignancies, ultimately improving patient outcomes.https://doi.org/10.1007/s12672-025-03041-wRadiation therapyThyroid malignant tumorsCerebrovascular death |
| spellingShingle | Xianghong Wang Xian Yang Ruxin Wang Chuanchuan Sun Hongyun Lu The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors Discover Oncology Radiation therapy Thyroid malignant tumors Cerebrovascular death |
| title | The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors |
| title_full | The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors |
| title_fullStr | The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors |
| title_full_unstemmed | The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors |
| title_short | The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors |
| title_sort | impact of different types of radiotherapy on cerebrovascular specific death in patients with thyroid malignant tumors |
| topic | Radiation therapy Thyroid malignant tumors Cerebrovascular death |
| url | https://doi.org/10.1007/s12672-025-03041-w |
| work_keys_str_mv | AT xianghongwang theimpactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors AT xianyang theimpactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors AT ruxinwang theimpactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors AT chuanchuansun theimpactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors AT hongyunlu theimpactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors AT xianghongwang impactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors AT xianyang impactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors AT ruxinwang impactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors AT chuanchuansun impactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors AT hongyunlu impactofdifferenttypesofradiotherapyoncerebrovascularspecificdeathinpatientswiththyroidmalignanttumors |