Molecular mechanisms of unique therapeutic potential of CUDC-907 for MEF2D fusion-driven BCP-ALL

Molecular mechanisms of unique therapeutic potential of CUDC-907 for MEF2D fusion-driven BCP-ALL

Abstract MEF2D fusions are found in a special subtype of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with poor prognosis. In this study, we conducted high-throughput drug screenings using cell line and ex vivo cell model harboring, respectively, MEF2D::HNRNPUL1(MH) and MEF2D::BCL9(MB), t...

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Main Authors: Qing Xue, Ming Zhang, Yixiao Mo, Bo Jiao, Xuan Liu, Minghao Jiang, Yu Zhou, Yun Tan, Huimin Li, Jianming Zhang, Qianqian Zhang, Yunqi Li, Jianfeng Li, Xiaofang Ma, Duo-Hui Jing, Jian-Qing Mi, Jin Wang, Zhu Chen, Shu-Hong Shen, Sai-Juan Chen
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02310-y
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https://doi.org/10.1038/s41392-025-02310-y

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