The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysis
Abstract This study aims to evaluate the association between IDO index and the prognosis of colorectal cancer (CRC). We searched databases such as PubMed, to collect relevant English studies on the association between IDO level and the prognosis of CRC published before October 10, 2024. This meta-an...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-04124-2 |
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| author | Tingting Yuan Guiqing Jia Wei Cao Haixia Chen Jing Zhang Min Liu Wenwen Gan Yanli Zeng |
| author_facet | Tingting Yuan Guiqing Jia Wei Cao Haixia Chen Jing Zhang Min Liu Wenwen Gan Yanli Zeng |
| author_sort | Tingting Yuan |
| collection | DOAJ |
| description | Abstract This study aims to evaluate the association between IDO index and the prognosis of colorectal cancer (CRC). We searched databases such as PubMed, to collect relevant English studies on the association between IDO level and the prognosis of CRC published before October 10, 2024. This meta-analysis included 11 studies involving 2068 patients. The results showed that IDO levels were not significantly correlated with OS in CRC patients (HR0.85, 95%CI 0.54–1.33, P = 0.488), but elevated IDO was associated with reduced disease-free survival (DFS) in CRC patients (HR 0.61, 95%CI 0.38–0.99, P = 0.044).Elevated IDO was significantly associated with the incidence of liver metastasis (HR 4.66, 95%CI 1.72–12.64, P = 0.003) and lymphatic infiltration (HR 2.75, 95%CI 1.52–4.97, P < 0.001) in CRC patients. In conclusion, high expression of IDO is significantly associated with DFS, liver metastasis and lymphatic infiltration in CRC patients, and may serve as a biomarker and therapeutic target for DFS, liver metastasis, and lymphatic metastasis in CRC. |
| format | Article |
| id | doaj-art-86fee6e004d8435389ec7e164c12cfb9 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-86fee6e004d8435389ec7e164c12cfb92025-08-24T11:33:05ZengBMCBMC Gastroenterology1471-230X2025-08-0125111110.1186/s12876-025-04124-2The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysisTingting Yuan0Guiqing Jia1Wei Cao2Haixia Chen3Jing Zhang4Min Liu5Wenwen Gan6Yanli Zeng7Department of Gastrointestinal Surgery, Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of ChinaDepartment of Gastrointestinal Surgery, Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Gastrointestinal Surgery, Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of ChinaDepartment of Thoracic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Anesthesiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Gastrointestinal Surgery, Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of ChinaCollege of Nursing, Chengdu University of Traditional Chinese MedicineAbstract This study aims to evaluate the association between IDO index and the prognosis of colorectal cancer (CRC). We searched databases such as PubMed, to collect relevant English studies on the association between IDO level and the prognosis of CRC published before October 10, 2024. This meta-analysis included 11 studies involving 2068 patients. The results showed that IDO levels were not significantly correlated with OS in CRC patients (HR0.85, 95%CI 0.54–1.33, P = 0.488), but elevated IDO was associated with reduced disease-free survival (DFS) in CRC patients (HR 0.61, 95%CI 0.38–0.99, P = 0.044).Elevated IDO was significantly associated with the incidence of liver metastasis (HR 4.66, 95%CI 1.72–12.64, P = 0.003) and lymphatic infiltration (HR 2.75, 95%CI 1.52–4.97, P < 0.001) in CRC patients. In conclusion, high expression of IDO is significantly associated with DFS, liver metastasis and lymphatic infiltration in CRC patients, and may serve as a biomarker and therapeutic target for DFS, liver metastasis, and lymphatic metastasis in CRC.https://doi.org/10.1186/s12876-025-04124-2Colorectal cancerTryptophan 23-dioxygenase |
| spellingShingle | Tingting Yuan Guiqing Jia Wei Cao Haixia Chen Jing Zhang Min Liu Wenwen Gan Yanli Zeng The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysis BMC Gastroenterology Colorectal cancer Tryptophan 2 3-dioxygenase |
| title | The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysis |
| title_full | The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysis |
| title_fullStr | The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysis |
| title_full_unstemmed | The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysis |
| title_short | The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysis |
| title_sort | prognostic value of indoleamine 2 3 dioxygenase in colorectal cancer a systematic review and meta analysis |
| topic | Colorectal cancer Tryptophan 2 3-dioxygenase |
| url | https://doi.org/10.1186/s12876-025-04124-2 |
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