Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review
In the early sixties, a discussion started regarding the association between Parkinson’s disease (PD) and type II diabetes mellitus (T2DM). Today, this potential relationship is still a matter of debate. This review aims to analyze both diseases concerning causal relationships and treatments. A tota...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2019/4951379 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849401007662956544 |
|---|---|
| author | Fauze Camargo Maluf David Feder Alzira Alves de Siqueira Carvalho |
| author_facet | Fauze Camargo Maluf David Feder Alzira Alves de Siqueira Carvalho |
| author_sort | Fauze Camargo Maluf |
| collection | DOAJ |
| description | In the early sixties, a discussion started regarding the association between Parkinson’s disease (PD) and type II diabetes mellitus (T2DM). Today, this potential relationship is still a matter of debate. This review aims to analyze both diseases concerning causal relationships and treatments. A total of 104 articles were found, and studies on animal and “in vitro” models showed that T2DM causes neurological alterations that may be associated with PD, such as deregulation of the dopaminergic system, a decrease in the expression of peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), an increase in the expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes 15 (PED/PEA-15), and neuroinflammation, as well as acceleration of the formation of alpha-synuclein amyloid fibrils. In addition, clinical studies described that Parkinson’s symptoms were notably worse after the onset of T2DM, and seven deregulated genes were identified in the DNA of T2DM and PD patients. Regarding treatment, the action of antidiabetic drugs, especially incretin mimetic agents, seems to confer certain degree of neuroprotection to PD patients. In conclusion, the available evidence on the interaction between T2DM and PD justifies more robust clinical trials exploring this interaction especially the clinical management of patients with both conditions. |
| format | Article |
| id | doaj-art-86fdbefd5a964008ba7512035affd4bf |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-86fdbefd5a964008ba7512035affd4bf2025-08-20T03:37:52ZengWileyParkinson's Disease2090-80832042-00802019-01-01201910.1155/2019/49513794951379Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic ReviewFauze Camargo Maluf0David Feder1Alzira Alves de Siqueira Carvalho2Medical Student of Centro Universitario Saude ABC, Centro Universitario Saude ABC, FMABC, Santo Andre 09060-870, BrazilDepartment of Pharmacology, Centro Universitario Saude ABC, FMABC, Santo Andre 09060-870, BrazilDepartment of Neurosciences, Centro Universitario Saude ABC, FMABC, Santo Andre 09060-870, BrazilIn the early sixties, a discussion started regarding the association between Parkinson’s disease (PD) and type II diabetes mellitus (T2DM). Today, this potential relationship is still a matter of debate. This review aims to analyze both diseases concerning causal relationships and treatments. A total of 104 articles were found, and studies on animal and “in vitro” models showed that T2DM causes neurological alterations that may be associated with PD, such as deregulation of the dopaminergic system, a decrease in the expression of peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), an increase in the expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes 15 (PED/PEA-15), and neuroinflammation, as well as acceleration of the formation of alpha-synuclein amyloid fibrils. In addition, clinical studies described that Parkinson’s symptoms were notably worse after the onset of T2DM, and seven deregulated genes were identified in the DNA of T2DM and PD patients. Regarding treatment, the action of antidiabetic drugs, especially incretin mimetic agents, seems to confer certain degree of neuroprotection to PD patients. In conclusion, the available evidence on the interaction between T2DM and PD justifies more robust clinical trials exploring this interaction especially the clinical management of patients with both conditions.http://dx.doi.org/10.1155/2019/4951379 |
| spellingShingle | Fauze Camargo Maluf David Feder Alzira Alves de Siqueira Carvalho Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review Parkinson's Disease |
| title | Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review |
| title_full | Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review |
| title_fullStr | Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review |
| title_full_unstemmed | Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review |
| title_short | Analysis of the Relationship between Type II Diabetes Mellitus and Parkinson’s Disease: A Systematic Review |
| title_sort | analysis of the relationship between type ii diabetes mellitus and parkinson s disease a systematic review |
| url | http://dx.doi.org/10.1155/2019/4951379 |
| work_keys_str_mv | AT fauzecamargomaluf analysisoftherelationshipbetweentypeiidiabetesmellitusandparkinsonsdiseaseasystematicreview AT davidfeder analysisoftherelationshipbetweentypeiidiabetesmellitusandparkinsonsdiseaseasystematicreview AT alziraalvesdesiqueiracarvalho analysisoftherelationshipbetweentypeiidiabetesmellitusandparkinsonsdiseaseasystematicreview |