Diazenium Betaines Derived from the Stable Free Radical DPPH with Diradicaloid Behavior

Starting from the well known stable free radical DPPH (or its reduced counterpart, 2,2-diphenyl-1-picryl-hydrazine) and several amino derivatives, novel zwitterionic compounds (diazenium betaines) were obtained and characterized by different means, like NMR, IR, MS, and UV–Vis. These betaines are hi...

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Main Authors: Adela F. Dobre, Augustin M. Mădălan, Anamaria Hanganu, Petre Ionita
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Chemistry
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Online Access:https://www.mdpi.com/2624-8549/6/5/52
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author Adela F. Dobre
Augustin M. Mădălan
Anamaria Hanganu
Petre Ionita
author_facet Adela F. Dobre
Augustin M. Mădălan
Anamaria Hanganu
Petre Ionita
author_sort Adela F. Dobre
collection DOAJ
description Starting from the well known stable free radical DPPH (or its reduced counterpart, 2,2-diphenyl-1-picryl-hydrazine) and several amino derivatives, novel zwitterionic compounds (diazenium betaines) were obtained and characterized by different means, like NMR, IR, MS, and UV–Vis. These betaines are highly intense blue-colored compounds that can be easily reduced by ascorbic acid (vitamin C) or sodium ascorbate to their corresponding <i>para</i>-phenyl substituted derivatives of DPPH, which have a yellow color. Most of such redox processes were found to be reversible. However, the oxidation of 2-<i>p</i>-aminophenyl-2-phenyl-1-picryl-hydrazine led to an azo-derivative of DPPH diradical, and its structure was unveiled by X-ray monocrystal diffraction. Possible diradicaloid behavior is also discussed.
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spelling doaj-art-86f81a40521943689b0a28d8fc8cb46e2025-08-20T02:10:59ZengMDPI AGChemistry2624-85492024-09-016589991010.3390/chemistry6050052Diazenium Betaines Derived from the Stable Free Radical DPPH with Diradicaloid BehaviorAdela F. Dobre0Augustin M. Mădălan1Anamaria Hanganu2Petre Ionita3Department of Inorganic, Organic, Bioorganic and Catalysis, Faculty of Chemistry, University of Bucharest, Panduri 90, 050663 Bucharest, RomaniaDepartment of Inorganic, Organic, Bioorganic and Catalysis, Faculty of Chemistry, University of Bucharest, Panduri 90, 050663 Bucharest, RomaniaDepartment of Inorganic, Organic, Bioorganic and Catalysis, Faculty of Chemistry, University of Bucharest, Panduri 90, 050663 Bucharest, RomaniaDepartment of Inorganic, Organic, Bioorganic and Catalysis, Faculty of Chemistry, University of Bucharest, Panduri 90, 050663 Bucharest, RomaniaStarting from the well known stable free radical DPPH (or its reduced counterpart, 2,2-diphenyl-1-picryl-hydrazine) and several amino derivatives, novel zwitterionic compounds (diazenium betaines) were obtained and characterized by different means, like NMR, IR, MS, and UV–Vis. These betaines are highly intense blue-colored compounds that can be easily reduced by ascorbic acid (vitamin C) or sodium ascorbate to their corresponding <i>para</i>-phenyl substituted derivatives of DPPH, which have a yellow color. Most of such redox processes were found to be reversible. However, the oxidation of 2-<i>p</i>-aminophenyl-2-phenyl-1-picryl-hydrazine led to an azo-derivative of DPPH diradical, and its structure was unveiled by X-ray monocrystal diffraction. Possible diradicaloid behavior is also discussed.https://www.mdpi.com/2624-8549/6/5/52free radicalDPPHbetainesynthesisstructural characterizationESR
spellingShingle Adela F. Dobre
Augustin M. Mădălan
Anamaria Hanganu
Petre Ionita
Diazenium Betaines Derived from the Stable Free Radical DPPH with Diradicaloid Behavior
Chemistry
free radical
DPPH
betaine
synthesis
structural characterization
ESR
title Diazenium Betaines Derived from the Stable Free Radical DPPH with Diradicaloid Behavior
title_full Diazenium Betaines Derived from the Stable Free Radical DPPH with Diradicaloid Behavior
title_fullStr Diazenium Betaines Derived from the Stable Free Radical DPPH with Diradicaloid Behavior
title_full_unstemmed Diazenium Betaines Derived from the Stable Free Radical DPPH with Diradicaloid Behavior
title_short Diazenium Betaines Derived from the Stable Free Radical DPPH with Diradicaloid Behavior
title_sort diazenium betaines derived from the stable free radical dpph with diradicaloid behavior
topic free radical
DPPH
betaine
synthesis
structural characterization
ESR
url https://www.mdpi.com/2624-8549/6/5/52
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