THERAPEUTIC EFFICACY OF ATROPINE AGAINST CHOLINESTERASE INHIBITORS TOXICITY IN CHICKS STRESSED WITH HYDROGEN PEROXIDE
The aim of this study was to evaluate therapeutic efficacy of atropine in case ofcholinesterase (ChE) inhibitors toxicity in chicks subjected to oxidative stress (OS) withhydrogen peroxide (H2O2). H2O2 at 0.5 % in drinking water induced OS at age of 7-14days in the chicks when given each day for 14...
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College of Veterinary Medicine, University of Basrah, Iraq
2016-05-01
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| Series: | Basrah Journal of Veterinary Research |
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| Online Access: | https://bjvr.uobasrah.edu.iq/article_174900_ec07b7f80b812a383a98936bfd698271.pdf |
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| author | Yaareb J. Mousa Muna H. I. Al-Zubaidy Sawsen M. Ameen Fouad K. Mohammad |
| author_facet | Yaareb J. Mousa Muna H. I. Al-Zubaidy Sawsen M. Ameen Fouad K. Mohammad |
| author_sort | Yaareb J. Mousa |
| collection | DOAJ |
| description | The aim of this study was to evaluate therapeutic efficacy of atropine in case ofcholinesterase (ChE) inhibitors toxicity in chicks subjected to oxidative stress (OS) withhydrogen peroxide (H2O2). H2O2 at 0.5 % in drinking water induced OS at age of 7-14days in the chicks when given each day for 14 consecutive days. There was no change inthe acute median lethal dose (LD50) for diazinon (7.9 mg/kg, orally) for both H2O(control) and H2O2 groups. The therapeutic efficacy of atropine was decreased (265 %)when measuring the median effective dose (ED50) for treating the diazinon toxicity inH2O group (2.6 mg/kg, i.m.) and in the H2O2 group (9.5 mg/kg, i.m.). The signs of acutediazinon toxicity were found to increase in H2O2 groups when compared to H2O groupand there is slight decrease in plasma and whole brain ChE activities in H2O2 group whenwhen compared to H2O group. The data revealed a decline in atropine efficacy for
treatment diazinon toxicity in chicks that suffered from OS status and it is recommendedhere to increase the dose of atropine in this case. |
| format | Article |
| id | doaj-art-86f7433fc3c14f9f8e9cf9ea1370bcfb |
| institution | Kabale University |
| issn | 1813-8497 2410-8456 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | College of Veterinary Medicine, University of Basrah, Iraq |
| record_format | Article |
| series | Basrah Journal of Veterinary Research |
| spelling | doaj-art-86f7433fc3c14f9f8e9cf9ea1370bcfb2025-08-20T03:49:44ZengCollege of Veterinary Medicine, University of Basrah, IraqBasrah Journal of Veterinary Research1813-84972410-84562016-05-0115423024210.23975/bjvetr.2016.174900174900THERAPEUTIC EFFICACY OF ATROPINE AGAINST CHOLINESTERASE INHIBITORS TOXICITY IN CHICKS STRESSED WITH HYDROGEN PEROXIDEYaareb J. Mousa0Muna H. I. Al-Zubaidy1Sawsen M. Ameen2Fouad K. Mohammad3Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqMinistry of Higher Education and Scientific Research, Baghdad, IraqThe aim of this study was to evaluate therapeutic efficacy of atropine in case ofcholinesterase (ChE) inhibitors toxicity in chicks subjected to oxidative stress (OS) withhydrogen peroxide (H2O2). H2O2 at 0.5 % in drinking water induced OS at age of 7-14days in the chicks when given each day for 14 consecutive days. There was no change inthe acute median lethal dose (LD50) for diazinon (7.9 mg/kg, orally) for both H2O(control) and H2O2 groups. The therapeutic efficacy of atropine was decreased (265 %)when measuring the median effective dose (ED50) for treating the diazinon toxicity inH2O group (2.6 mg/kg, i.m.) and in the H2O2 group (9.5 mg/kg, i.m.). The signs of acutediazinon toxicity were found to increase in H2O2 groups when compared to H2O groupand there is slight decrease in plasma and whole brain ChE activities in H2O2 group whenwhen compared to H2O group. The data revealed a decline in atropine efficacy for treatment diazinon toxicity in chicks that suffered from OS status and it is recommendedhere to increase the dose of atropine in this case.https://bjvr.uobasrah.edu.iq/article_174900_ec07b7f80b812a383a98936bfd698271.pdfatropineoxidative stressh2o2chicks |
| spellingShingle | Yaareb J. Mousa Muna H. I. Al-Zubaidy Sawsen M. Ameen Fouad K. Mohammad THERAPEUTIC EFFICACY OF ATROPINE AGAINST CHOLINESTERASE INHIBITORS TOXICITY IN CHICKS STRESSED WITH HYDROGEN PEROXIDE Basrah Journal of Veterinary Research atropine oxidative stress h2o2 chicks |
| title | THERAPEUTIC EFFICACY OF ATROPINE AGAINST CHOLINESTERASE INHIBITORS TOXICITY IN CHICKS STRESSED WITH HYDROGEN PEROXIDE |
| title_full | THERAPEUTIC EFFICACY OF ATROPINE AGAINST CHOLINESTERASE INHIBITORS TOXICITY IN CHICKS STRESSED WITH HYDROGEN PEROXIDE |
| title_fullStr | THERAPEUTIC EFFICACY OF ATROPINE AGAINST CHOLINESTERASE INHIBITORS TOXICITY IN CHICKS STRESSED WITH HYDROGEN PEROXIDE |
| title_full_unstemmed | THERAPEUTIC EFFICACY OF ATROPINE AGAINST CHOLINESTERASE INHIBITORS TOXICITY IN CHICKS STRESSED WITH HYDROGEN PEROXIDE |
| title_short | THERAPEUTIC EFFICACY OF ATROPINE AGAINST CHOLINESTERASE INHIBITORS TOXICITY IN CHICKS STRESSED WITH HYDROGEN PEROXIDE |
| title_sort | therapeutic efficacy of atropine against cholinesterase inhibitors toxicity in chicks stressed with hydrogen peroxide |
| topic | atropine oxidative stress h2o2 chicks |
| url | https://bjvr.uobasrah.edu.iq/article_174900_ec07b7f80b812a383a98936bfd698271.pdf |
| work_keys_str_mv | AT yaarebjmousa therapeuticefficacyofatropineagainstcholinesteraseinhibitorstoxicityinchicksstressedwithhydrogenperoxide AT munahialzubaidy therapeuticefficacyofatropineagainstcholinesteraseinhibitorstoxicityinchicksstressedwithhydrogenperoxide AT sawsenmameen therapeuticefficacyofatropineagainstcholinesteraseinhibitorstoxicityinchicksstressedwithhydrogenperoxide AT fouadkmohammad therapeuticefficacyofatropineagainstcholinesteraseinhibitorstoxicityinchicksstressedwithhydrogenperoxide |