Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model
BackgroundZingiber officinale Roscoe has been shown to possess analgesic properties. Zingerone (ZO), a bioactive compound derived from Zingiber officinale Roscoe, exhibits a range of pharmacological effects, including anti-inflammatory, anti-cancer, antioxidant, antibacterial, and anti-apoptotic act...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1543594/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850069500130492416 |
|---|---|
| author | Yuanyuan Wang Yuanyuan Wang Yuanyuan Wang Lang Dong Lang Dong Shu Han Yuehan You Mingrui Zhang Bingjing Sun Bingjing Sun Hong Ni Hong Ni Rongjing Ge Rongjing Ge Jianhong Liu Jianhong Liu Jiandong Yu Jiandong Yu Jiandong Yu |
| author_facet | Yuanyuan Wang Yuanyuan Wang Yuanyuan Wang Lang Dong Lang Dong Shu Han Yuehan You Mingrui Zhang Bingjing Sun Bingjing Sun Hong Ni Hong Ni Rongjing Ge Rongjing Ge Jianhong Liu Jianhong Liu Jiandong Yu Jiandong Yu Jiandong Yu |
| author_sort | Yuanyuan Wang |
| collection | DOAJ |
| description | BackgroundZingiber officinale Roscoe has been shown to possess analgesic properties. Zingerone (ZO), a bioactive compound derived from Zingiber officinale Roscoe, exhibits a range of pharmacological effects, including anti-inflammatory, anti-cancer, antioxidant, antibacterial, and anti-apoptotic activities. However, the analgesic properties of zingerone remain unclear.MethodsComplete Freund’s adjuvant (CFA) was administered to the left hind paw of C57BL/6 mice to induce a model of inflammatory pain. The analgesic effects of zingerone were assessed using the Von Frey and Hargreaves tests. In vivo fiber photometry and whole-cell patch clamp techniques were employed to investigate the potential mechanisms.ResultsBoth acute and long-term treatment with zingerone resulted in a significant increase in mechanical and thermal pain thresholds in mice experiencing CFA-induced inflammatory pain. Mechanical stimulation led to a pronounced increase in calcium levels within the anterior cingulate cortex (ACC) neurons of the inflammatory pain model, which was alleviated by zingerone administration. Furthermore, zingerone was found to modify synaptic transmission to ACC neurons and decrease their intrinsic excitability by prolonging the refractory period of these neurons.ConclusionZingerone demonstrates potential for alleviating CFA-induced inflammatory pain by reducing the intrinsic excitability of ACC neurons in a mouse model. |
| format | Article |
| id | doaj-art-86f12d59e2c24d0ba9347f7fc783bdf1 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-86f12d59e2c24d0ba9347f7fc783bdf12025-08-20T02:47:46ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.15435941543594Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice modelYuanyuan Wang0Yuanyuan Wang1Yuanyuan Wang2Lang Dong3Lang Dong4Shu Han5Yuehan You6Mingrui Zhang7Bingjing Sun8Bingjing Sun9Hong Ni10Hong Ni11Rongjing Ge12Rongjing Ge13Jianhong Liu14Jianhong Liu15Jiandong Yu16Jiandong Yu17Jiandong Yu18Department of Neurosurgery, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaSchool of Basic Medicine, Bengbu Medical University, Bengbu, Anhui, ChinaDepartment of Neurosurgery, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaSchool of Basic Medicine, Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaSchool of Basic Medicine, Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaSchool of Basic Medicine, Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaDepartment of Biochemistry and Molecular biology, School of Laboratory Medicine, Bengbu Medical University, Bengbu, Anhui, ChinaDepartment of Neurosurgery, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, ChinaLaboratory of Brain and Psychiatric Disease, Bengbu Medical University, Bengbu, Anhui, ChinaAnhui Engineering Research Center for Neural Regeneration Technology and Medical New Materials, Bengbu Medical University, Bengbu, Anhui, ChinaBackgroundZingiber officinale Roscoe has been shown to possess analgesic properties. Zingerone (ZO), a bioactive compound derived from Zingiber officinale Roscoe, exhibits a range of pharmacological effects, including anti-inflammatory, anti-cancer, antioxidant, antibacterial, and anti-apoptotic activities. However, the analgesic properties of zingerone remain unclear.MethodsComplete Freund’s adjuvant (CFA) was administered to the left hind paw of C57BL/6 mice to induce a model of inflammatory pain. The analgesic effects of zingerone were assessed using the Von Frey and Hargreaves tests. In vivo fiber photometry and whole-cell patch clamp techniques were employed to investigate the potential mechanisms.ResultsBoth acute and long-term treatment with zingerone resulted in a significant increase in mechanical and thermal pain thresholds in mice experiencing CFA-induced inflammatory pain. Mechanical stimulation led to a pronounced increase in calcium levels within the anterior cingulate cortex (ACC) neurons of the inflammatory pain model, which was alleviated by zingerone administration. Furthermore, zingerone was found to modify synaptic transmission to ACC neurons and decrease their intrinsic excitability by prolonging the refractory period of these neurons.ConclusionZingerone demonstrates potential for alleviating CFA-induced inflammatory pain by reducing the intrinsic excitability of ACC neurons in a mouse model.https://www.frontiersin.org/articles/10.3389/fphar.2025.1543594/fullZingiber officinale roscoeanalgesicintrinsic excitabilitycomplete Freund’s adjuvant (CFA)refractory periodelectrophysiological |
| spellingShingle | Yuanyuan Wang Yuanyuan Wang Yuanyuan Wang Lang Dong Lang Dong Shu Han Yuehan You Mingrui Zhang Bingjing Sun Bingjing Sun Hong Ni Hong Ni Rongjing Ge Rongjing Ge Jianhong Liu Jianhong Liu Jiandong Yu Jiandong Yu Jiandong Yu Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model Frontiers in Pharmacology Zingiber officinale roscoe analgesic intrinsic excitability complete Freund’s adjuvant (CFA) refractory period electrophysiological |
| title | Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model |
| title_full | Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model |
| title_fullStr | Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model |
| title_full_unstemmed | Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model |
| title_short | Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model |
| title_sort | zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model |
| topic | Zingiber officinale roscoe analgesic intrinsic excitability complete Freund’s adjuvant (CFA) refractory period electrophysiological |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1543594/full |
| work_keys_str_mv | AT yuanyuanwang zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT yuanyuanwang zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT yuanyuanwang zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT langdong zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT langdong zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT shuhan zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT yuehanyou zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT mingruizhang zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT bingjingsun zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT bingjingsun zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT hongni zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT hongni zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT rongjingge zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT rongjingge zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT jianhongliu zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT jianhongliu zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT jiandongyu zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT jiandongyu zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel AT jiandongyu zingeronealleviatesinflammatorypainbyreducingtheintrinsicexcitabilityofanteriorcingulatecortexneuronsinamicemodel |