ISOLATED HYPERTHERMIC CHEMOPERFUSION OF THE LIVER IN ITS METASTATIC LESIONS
OBJECTIVE. The aim of the study is to evaluate the clinical efficacy of isolated hyperthermic liver chemoperfusion with melphalan and tumor necrosis factor alpha when it is isolated bilobate metastatic lesion and the ineffectiveness of systemic chemotherapy in patients with colorectal cancer. MATERI...
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| Format: | Article |
| Language: | Russian |
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Pavlov First Saint Petersburg State Medical University
2018-02-01
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| Series: | Вестник хирургии имени И.И. Грекова |
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| Online Access: | https://www.vestnik-grekova.ru/jour/article/view/831 |
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| author | N. A. Maistrenko A. I. Babich P. N. Romashchenko Yu. A. Pobedinceva V. M. Unguryan V. A. Kudlachev T. Yu. Kushtan A. I. Strogonov |
| author_facet | N. A. Maistrenko A. I. Babich P. N. Romashchenko Yu. A. Pobedinceva V. M. Unguryan V. A. Kudlachev T. Yu. Kushtan A. I. Strogonov |
| author_sort | N. A. Maistrenko |
| collection | DOAJ |
| description | OBJECTIVE. The aim of the study is to evaluate the clinical efficacy of isolated hyperthermic liver chemoperfusion with melphalan and tumor necrosis factor alpha when it is isolated bilobate metastatic lesion and the ineffectiveness of systemic chemotherapy in patients with colorectal cancer. MATERIAL AND METHODS. The patient K, 67 y. o., with colorectal adenocarcinoma T3N0M1 (hep, 3 type). liver metastases were detected synchronously with the detection of the primary tumor. Resection of the primary tumor was performed at first, then there was systemic chemotherapy (6 FOLFOX and 3 FOLFIRI). The was tumor progression in liver after second-line chemotherapy. Isolated hyperthermic liver chemoperfusion was perfomed after complete vascular exclusion of the liver with parallel circulation to return blood to the system of the superior vena cava from the inferior vena cava and portal vein. hepatic perfusion in heart-lung machine with the chemotherapy drugs (melphalan and tumor necrosis factor alpha) carried out through the gastro-duodenal artery and back flow to the circulation circuit from the retro-hepatic vena cava. RESULTS. Using of the isolated hyperthermic liver chemoperfusion allowed reaching full necrosis of liver metastases that confirmed by histopathology results and CT data of the abdominal cavity in a month after the procedure. CONCLUSION. Isolated hyperthermic liver chemoperfusion with melphalan and tumor necrosis factor alpha is the effective method of regional chemotherapy, which is advisable in patients with unresectable isolated metastatic lesion of the liver and resistible to systemic chemotherapy. |
| format | Article |
| id | doaj-art-86f10614200349e99ebf21101d85d65d |
| institution | Kabale University |
| issn | 0042-4625 |
| language | Russian |
| publishDate | 2018-02-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj-art-86f10614200349e99ebf21101d85d65d2025-08-20T04:00:34ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252018-02-011771545910.24884/0042-4625-2018-177-1-54-59820ISOLATED HYPERTHERMIC CHEMOPERFUSION OF THE LIVER IN ITS METASTATIC LESIONSN. A. Maistrenko0A. I. Babich1P. N. Romashchenko2Yu. A. Pobedinceva3V. M. Unguryan4V. A. Kudlachev5T. Yu. Kushtan6A. I. Strogonov7S. M. Kirov Military Medical Academy, Ministry of Defence of the Russian Federation, Saint-PetersburgPC «Medex Clinic Kostroma» Regional State Budgetary Institution of Healthcare «Kostroma oncological dispensary», KostromaS. M. Kirov Military Medical Academy, Ministry of Defence of the Russian Federation, Saint-PetersburgPC «Medex Clinic Kostroma» Regional State Budgetary Institution of Healthcare «Kostroma oncological dispensary», KostromaPC «Medex Clinic Kostroma» Regional State Budgetary Institution of Healthcare «Kostroma oncological dispensary», KostromaPC «Medex Clinic Kostroma» Regional State Budgetary Institution of Healthcare «Kostroma oncological dispensary», KostromaS. M. Kirov Military Medical Academy, Ministry of Defence of the Russian Federation, Saint-PetersburgS. M. Kirov Military Medical Academy, Ministry of Defence of the Russian Federation, Saint-PetersburgOBJECTIVE. The aim of the study is to evaluate the clinical efficacy of isolated hyperthermic liver chemoperfusion with melphalan and tumor necrosis factor alpha when it is isolated bilobate metastatic lesion and the ineffectiveness of systemic chemotherapy in patients with colorectal cancer. MATERIAL AND METHODS. The patient K, 67 y. o., with colorectal adenocarcinoma T3N0M1 (hep, 3 type). liver metastases were detected synchronously with the detection of the primary tumor. Resection of the primary tumor was performed at first, then there was systemic chemotherapy (6 FOLFOX and 3 FOLFIRI). The was tumor progression in liver after second-line chemotherapy. Isolated hyperthermic liver chemoperfusion was perfomed after complete vascular exclusion of the liver with parallel circulation to return blood to the system of the superior vena cava from the inferior vena cava and portal vein. hepatic perfusion in heart-lung machine with the chemotherapy drugs (melphalan and tumor necrosis factor alpha) carried out through the gastro-duodenal artery and back flow to the circulation circuit from the retro-hepatic vena cava. RESULTS. Using of the isolated hyperthermic liver chemoperfusion allowed reaching full necrosis of liver metastases that confirmed by histopathology results and CT data of the abdominal cavity in a month after the procedure. CONCLUSION. Isolated hyperthermic liver chemoperfusion with melphalan and tumor necrosis factor alpha is the effective method of regional chemotherapy, which is advisable in patients with unresectable isolated metastatic lesion of the liver and resistible to systemic chemotherapy.https://www.vestnik-grekova.ru/jour/article/view/831isolated perfusionisolated chemoperfusion of the livercolorectal cancerregional chemotherapyliver metastasesmelphalantumor necrosis factor |
| spellingShingle | N. A. Maistrenko A. I. Babich P. N. Romashchenko Yu. A. Pobedinceva V. M. Unguryan V. A. Kudlachev T. Yu. Kushtan A. I. Strogonov ISOLATED HYPERTHERMIC CHEMOPERFUSION OF THE LIVER IN ITS METASTATIC LESIONS Вестник хирургии имени И.И. Грекова isolated perfusion isolated chemoperfusion of the liver colorectal cancer regional chemotherapy liver metastases melphalan tumor necrosis factor |
| title | ISOLATED HYPERTHERMIC CHEMOPERFUSION OF THE LIVER IN ITS METASTATIC LESIONS |
| title_full | ISOLATED HYPERTHERMIC CHEMOPERFUSION OF THE LIVER IN ITS METASTATIC LESIONS |
| title_fullStr | ISOLATED HYPERTHERMIC CHEMOPERFUSION OF THE LIVER IN ITS METASTATIC LESIONS |
| title_full_unstemmed | ISOLATED HYPERTHERMIC CHEMOPERFUSION OF THE LIVER IN ITS METASTATIC LESIONS |
| title_short | ISOLATED HYPERTHERMIC CHEMOPERFUSION OF THE LIVER IN ITS METASTATIC LESIONS |
| title_sort | isolated hyperthermic chemoperfusion of the liver in its metastatic lesions |
| topic | isolated perfusion isolated chemoperfusion of the liver colorectal cancer regional chemotherapy liver metastases melphalan tumor necrosis factor |
| url | https://www.vestnik-grekova.ru/jour/article/view/831 |
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